Tag | Content |
---|---|
UniProt Accession | AKTS1_HUMAN; Q96B36; |
Entrez ID | 84335 |
GenBank Protein ID | NM_001098632.2; NM_001098633.3; NM_001278159.1; NM_001278160.1; NM_032375.5; |
GenBank Nucleotide ID | NP_001092102.1; NP_001092103.1; NP_001265088.1; NP_001265089.1; NP_115751.3; |
Protein Name | Proline-rich AKT1 substrate 1 (40 kDa proline-rich AKT substrate) |
Gene Name | AKT1S1; PRAS40 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Subunit of mTORC1, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein(view all) |
Sequence (Fasta) | MASGRPEELW EAVVGAAERF RARTGTELVL LTAAPPPPPR PGPCAYAAHG RGALAEAARR 60 CLHDIALAHR AATAARPPAP PPAPQPPSPT PSPPRPTLAR EDNEEDEDEP TETETSGEQL 120 GISDNGGLFV MDEDATLQDL PPFCESDPES TDDGSLSEET PAGPPTCSVP PASALPTQQY 180 AKSLPVSVPV WGFKEKRTEA RSSDEENGPP SSPDLDRIAA SMRALVLREA EDTQVFGDLP 240 RPRLNTSDFQ KLKRKY 257 |
|
Database | Annotation |
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CTD (Curated) (count: 2) | MESH:D015427
; Reperfusion Injury MESH:D013119 ; Spinal Cord Injuries |
GWASdb (count: 1) | rs2290775; Nicotine dependence (smoking); nicotine dependence |
PTM | Modification Sites |
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Phosphorylation (count: 17) (view all) | 183 PTQQYAKSLPVSVPV dbPAF
187 YAKSLPVSVPVWGFK dbPAF 198 WGFKEKRTEARSSDE dbPAF 202 EKRTEARSSDEENGP dbPAF 203 KRTEARSSDEENGPP dbPAF 211 DEENGPPSSPDLDRI dbPAF |
Network | Interaction | ||
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A | B | Source | |