Q93045

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession STMN2_HUMAN; Q93045;
Entrez ID 11075
GenBank Protein ID NM_001199214.1; NM_007029.3;
GenBank Nucleotide ID NP_001186143.1; NP_008960.2;
Protein Name Stathmin-2 (Superior cervical ganglion-10 protein) (Protein SCG10)
Gene Name STMN2; SCG10; SCGN10
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionRegulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone (By similarity).
Sequence
(Fasta)
MAKTAMAYKE KMKELSMLSL ICSCFYPEPR NINIYTYDDM EVKQINKRAS GQAFELILKP 60
PSPISEAPRT LASPKKKDLS LEEIQKKLEA AEERRKSQEA QVLKQLAEKR EHEREVLQKA 120
LEENNNFSKM AEEKLILKME QIKENREANL AAIIERLQEK ERHAAEVRRN KELQVELSG 180

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Serine PhosphorylationGastric cancerPS5023893240
[Reference]: PAK4 kinase-mediated SCG10 phosphorylation involved in gastric cancer metastasis

※ Disease Cross-ref Annotation

DatabaseAnnotation
GWASdb
(count: 5)
rs6473171; Sarcoidosis; sarcoidosis
rs16907010; Response to statin treatment (atorvastatin), change in cholesterol levels; cardiovascular system disease
rs4739642; Chronic obstructive pulmonary disease; chronic obstructive pulmonary disease
rs4739642; Response to statin treatment (atorvastatin), change in cholesterol levels; cardiovascular system disease
rs2979715; Osteoarthritis; osteoarthritis

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 11)
(view all)
128       LEENNNFSKMAEEKL     dbPAF
16        KEKMKELSMLSLICS     dbPAF
19        MKELSMLSLICSCFY     dbPAF
23        SMLSLICSCFYPEPR     dbPAF
35        EPRNINIYTYDDMEV     dbPAF
50        KQINKRASGQAFELI     dbPAF
Acetylation
(count: 2)
119       HEREVLQKALEENNN     PLMD
129       EENNNFSKMAEEKLI     PLMD
Ubiquitination
(count: 3)
119       HEREVLQKALEENNN     PLMD
129       EENNNFSKMAEEKLI     PLMD
59        QAFELILKPPSPISE     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource