Tag | Content |
---|---|
UniProt Accession | STMN2_HUMAN; Q93045; |
Entrez ID | 11075 |
GenBank Protein ID | NM_001199214.1; NM_007029.3; |
GenBank Nucleotide ID | NP_001186143.1; NP_008960.2; |
Protein Name | Stathmin-2 (Superior cervical ganglion-10 protein) (Protein SCG10) |
Gene Name | STMN2; SCG10; SCGN10 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone (By similarity). |
Sequence (Fasta) | MAKTAMAYKE KMKELSMLSL ICSCFYPEPR NINIYTYDDM EVKQINKRAS GQAFELILKP 60 PSPISEAPRT LASPKKKDLS LEEIQKKLEA AEERRKSQEA QVLKQLAEKR EHEREVLQKA 120 LEENNNFSKM AEEKLILKME QIKENREANL AAIIERLQEK ERHAAEVRRN KELQVELSG 180 |
|
Database | Annotation |
---|---|
GWASdb (count: 5) | rs6473171; Sarcoidosis; sarcoidosis
rs16907010; Response to statin treatment (atorvastatin), change in cholesterol levels; cardiovascular system disease rs4739642; Chronic obstructive pulmonary disease; chronic obstructive pulmonary disease rs4739642; Response to statin treatment (atorvastatin), change in cholesterol levels; cardiovascular system disease rs2979715; Osteoarthritis; osteoarthritis |
PTM | Modification Sites |
---|---|
Phosphorylation (count: 11) (view all) | 128 LEENNNFSKMAEEKL dbPAF
16 KEKMKELSMLSLICS dbPAF 19 MKELSMLSLICSCFY dbPAF 23 SMLSLICSCFYPEPR dbPAF 35 EPRNINIYTYDDMEV dbPAF 50 KQINKRASGQAFELI dbPAF |
Acetylation (count: 2) | 119 HEREVLQKALEENNN PLMD
129 EENNNFSKMAEEKLI PLMD |
Ubiquitination (count: 3) | 119 HEREVLQKALEENNN PLMD
129 EENNNFSKMAEEKLI PLMD 59 QAFELILKPPSPISE PLMD |
Network | Interaction | ||
---|---|---|---|
A | B | Source | |