| Tag | Content |
|---|---|
| UniProt Accession | BAD_HUMAN; Q92934; |
| Entrez ID | 572 |
| GenBank Protein ID | NM_004322.3; NM_032989.2; |
| GenBank Nucleotide ID | NP_004313.1; NP_116784.1; |
| Protein Name | Bcl2-associated agonist of cell death (BAD) (Bcl-2-binding component 6) (Bcl-2-like protein 8) (Bcl2-L-8) (Bcl-xL/Bcl-2-associated death promoter) (Bcl2 antagonist of cell death) |
| Gene Name | BAD; BBC6; BCL2L8 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways. |
| Sequence (Fasta) | MFQIPEFEPS EQEDSSSAER GLGPSPAGDG PSGSGKHHRQ APGLLWDASH QQEQPTSSSH 60 HGGAGAVEIR SRHSSYPAGT EDDEGMGEEP SPFRGRSRSA PPNLWAAQRY GRELRRMSDE 120 FVDSFKKGLP RPKSAGTATQ MRQSSSWTRV FQSWWDRNLG RGSSAPSQ 169 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 3) | MESH:D002546
; Ischemic Attack, Transient MESH:D007938 ; Leukemia MESH:D011471 ; Prostatic Neoplasms |
| GWASdb (count: 2) | rs671976; HDL cholesterol; cholesterol ester storage disease|cholesterol embolism|coronary artery disease
rs477895; Mean platelet volume; myocardial infarction|hematopoietic system disease |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 20) (view all) | 110 NLWAAQRYGRELRRM dbPAF
118 GRELRRMSDEFVDSF dbPAF 124 MSDEFVDSFKKGLPR dbPAF 134 KGLPRPKSAGTATQM dbPAF 137 PRPKSAGTATQMRQS dbPAF 139 PKSAGTATQMRQSSS dbPAF |
| Acetylation (count: 1) | 36 DGPSGSGKHHRQAPG PLMD |
| Network | Interaction | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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