Tag | Content |
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UniProt Accession | BAD_HUMAN; Q92934; |
Entrez ID | 572 |
GenBank Protein ID | NM_004322.3; NM_032989.2; |
GenBank Nucleotide ID | NP_004313.1; NP_116784.1; |
Protein Name | Bcl2-associated agonist of cell death (BAD) (Bcl-2-binding component 6) (Bcl-2-like protein 8) (Bcl2-L-8) (Bcl-xL/Bcl-2-associated death promoter) (Bcl2 antagonist of cell death) |
Gene Name | BAD; BBC6; BCL2L8 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways. |
Sequence (Fasta) | MFQIPEFEPS EQEDSSSAER GLGPSPAGDG PSGSGKHHRQ APGLLWDASH QQEQPTSSSH 60 HGGAGAVEIR SRHSSYPAGT EDDEGMGEEP SPFRGRSRSA PPNLWAAQRY GRELRRMSDE 120 FVDSFKKGLP RPKSAGTATQ MRQSSSWTRV FQSWWDRNLG RGSSAPSQ 169 |
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Database | Annotation |
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CTD (Curated) (count: 3) | MESH:D002546
; Ischemic Attack, Transient MESH:D007938 ; Leukemia MESH:D011471 ; Prostatic Neoplasms |
GWASdb (count: 2) | rs671976; HDL cholesterol; cholesterol ester storage disease|cholesterol embolism|coronary artery disease
rs477895; Mean platelet volume; myocardial infarction|hematopoietic system disease |
PTM | Modification Sites |
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Phosphorylation (count: 20) (view all) | 110 NLWAAQRYGRELRRM dbPAF
118 GRELRRMSDEFVDSF dbPAF 124 MSDEFVDSFKKGLPR dbPAF 134 KGLPRPKSAGTATQM dbPAF 137 PRPKSAGTATQMRQS dbPAF 139 PKSAGTATQMRQSSS dbPAF |
Acetylation (count: 1) | 36 DGPSGSGKHHRQAPG PLMD |
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