| Tag | Content |
|---|---|
| UniProt Accession | CSN5_HUMAN; Q92905; |
| Entrez ID | 10987 |
| GenBank Protein ID | |
| GenBank Nucleotide ID | |
| Protein Name | COP9 signalosome complex subunit 5 (SGN5) (Signalosome subunit 5) (EC 3.4.-.-) (Jun activation domain-binding protein 1) |
| Gene Name | COPS5; CSN5; JAB1 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts directly with a large number of proteins that are regulated by the CSN complex, confirming a key role in the complex. Promotes the proteasomal degradation of BRSK2. |
| Sequence (Fasta) | MAASGSGMAQ KTWELANNMQ EAQSIDEIYK YDKKQQQEIL AAKPWTKDHH YFKYCKISAL 60 ALLKMVMHAR SGGNLEVMGL MLGKVDGETM IIMDSFALPV EGTETRVNAQ AAAYEYMAAY 120 IENAKQVGRL ENAIGWYHSH PGYGCWLSGI DVSTQMLNQQ FQEPFVAVVI DPTRTISAGK 180 VNLGAFRTYP KGYKPPDEGP SEYQTIPLNK IEDFGVHCKQ YYALEVSYFK SSLDRKLLEL 240 LWNKYWVNTL SSSSLLTNAD YTTGQVFDLS EKLEQSEAQL GRGSFMLGLE THDRKSEDKL 300 AKATRDSCKT TIEAIHGLMS QVIKDKLFNQ INIS 335 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 2) | MESH:D006528
; Carcinoma, Hepatocellular MESH:D013262 ; Stevens-Johnson Syndrome |
| DisGeNet (Curated) (count: 2) | C0038325; Stevens-Johnson Syndrome
C2239176; Liver carcinoma |
| GWASdb (count: 2) | rs6997490; Atrial fibrillation; familial atrial fibrillation
rs6997490; Prostate cancer; prostate cancer |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 6) | 120 AYEYMAAYIENAKQV dbPAF
203 PDEGPSEYQTIPLNK dbPAF 261 SLLTNADYTTGQVFD dbPAF 320 EAIHGLMSQVIKDKL dbPAF 54 KDHHYFKYCKISALA dbPAF 71 KMVMHARSGGNLEVM dbPAF |
| Acetylation (count: 4) | 194 RTYPKGYKPPDEGPS PLMD
210 YQTIPLNKIEDFGVH PLMD 47 LAAKPWTKDHHYFKY PLMD 53 TKDHHYFKYCKISAL PLMD |
| Ubiquitination (count: 16) (view all) | 11 SGSGMAQKTWELANN PLMD
125 AAYIENAKQVGRLEN PLMD 180 TRTISAGKVNLGAFR PLMD 191 GAFRTYPKGYKPPDE PLMD 194 RTYPKGYKPPDEGPS PLMD 210 YQTIPLNKIEDFGVH PLMD |