| Tag | Content |
|---|---|
| UniProt Accession | ESR2_HUMAN; Q92731; |
| Entrez ID | 2100 |
| GenBank Protein ID | NM_001040275.1; NM_001214902.1; NM_001271876.1; NM_001271877.1; NM_001291712.1; NM_001291723.1; NM_001437.2; XM_017021079.1; XM_017021080.1; XM_017021081.1; XM_017021082.1; XM_017021083.1; XM_017021084.1; |
| GenBank Nucleotide ID | NP_001035365.1; NP_001201831.1; NP_001258805.1; NP_001258806.1; NP_001278641.1; NP_001278652.1; NP_001428.1; XP_016876568.1; XP_016876569.1; XP_016876570.1; XP_016876571.1; XP_016876572.1; XP_016876573.1; |
| Protein Name | Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2) |
| Gene Name | ESR2; ESTRB; NR3A2 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner (PubMed:20074560). Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual. |
| Sequence (Fasta) | MDIKNSPSSL NSPSSYNCSQ SILPLEHGSI YIPSSYVDSH HEYPAMTFYS PAVMNYSIPS 60 NVTNLEGGPG RQTTSPNVLW PTPGHLSPLV VHRQLSHLYA EPQKSPWCEA RSLEHTLPVN 120 RETLKRKVSG NRCASPVTGP GSKRDAHFCA VCSDYASGYH YGVWSCEGCK AFFKRSIQGH 180 NDYICPATNQ CTIDKNRRKS CQACRLRKCY EVGMVKCGSR RERCGYRLVR RQRSADEQLH 240 CAGKAKRSGG HAPRVRELLL DALSPEQLVL TLLEAEPPHV LISRPSAPFT EASMMMSLTK 300 LADKELVHMI SWAKKIPGFV ELSLFDQVRL LESCWMEVLM MGLMWRSIDH PGKLIFAPDL 360 VLDRDEGKCV EGILEIFDML LATTSRFREL KLQHKEYLCV KAMILLNSSM YPLVTATQDA 420 DSSRKLAHLL NAVTDALVWV IAKSGISSQQ QSMRLANLLM LLSHVRHASN KGMEHLLNMK 480 CKNVVPVYDL LLEMLNAHVL RGCKSSITGS ECSPAEDSKS KEGSQNPQSQ 531 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 20) (view all) | MESH:D000230
; Adenocarcinoma MESH:D001145 ; Arrhythmias, Cardiac MESH:D001254 ; Astrocytoma MESH:D001943 ; Breast Neoplasms MESH:D002277 ; Carcinoma MESH:D002295 ; Carcinoma, Transitional Cell |
| DisGeNet (Curated) (count: 24) (view all) | C0001418; Adenocarcinoma
C0003811; Cardiac Arrhythmia C0004114; Astrocytoma C0005695; Bladder Neoplasm C0007138; Carcinoma, Transitional Cell C0009404; Colorectal Neoplasms |
| GWASdb (count: 16) (view all) | rs1255998; Coronary heart disease; coronary artery disease
rs8006145; Non-obstructive azoospermia; azoospermia rs4986938; Drug response to Tamoxifen; Null rs1256063; Stroke; cerebrovascular disease rs1256061; Red blood cell traits; hematopoietic system disease rs11850375; HDL cholesterol; cholesterol ester storage disease|cholesterol embolism|coronary artery disease |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 11) (view all) | 105 LYAEPQKSPWCEARS dbPAF
135 VSGNRCASPVTGPGS dbPAF 165 GYHYGVWSCEGCKAF dbPAF 176 CKAFFKRSIQGHNDY dbPAF 200 IDKNRRKSCQACRLR dbPAF 36 SIYIPSSYVDSHHEY dbPAF |
| Sumoylation (count: 1) | 4 ****MDIKNSPSSLN PLMD |
| Network | Interaction | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| A | B | Source | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
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