| Tag | Content |
|---|---|
| UniProt Accession | NDRG1_HUMAN; Q92597; |
| Entrez ID | 10397 |
| GenBank Protein ID | NM_001135242.1; NM_001258432.1; NM_001258433.1; NM_006096.3; |
| GenBank Nucleotide ID | NP_001128714.1; NP_001245361.1; NP_001245362.1; NP_006087.2; |
| Protein Name | Protein NDRG1 (Differentiation-related gene 1 protein) (DRG-1) (N-myc downstream-regulated gene 1 protein) (Nickel-specific induction protein Cap43) (Reducing agents and tunicamycin-responsive protein) (RTP) (Rit42) |
| Gene Name | NDRG1; CAP43; DRG1; RTP |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53-mediated caspase activation and apoptosis. Has a role in cell trafficking, notably of the Schwann cell, and is necessary for the maintenance and development of the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle checkpoint. Regulates microtubule dynamics and maintains euploidy. |
| Sequence (Fasta) | MSREMQDVDL AEVKPLVEKG ETITGLLQEF DVQEQDIETL HGSVHVTLCG TPKGNRPVIL 60 TYHDIGMNHK TCYNPLFNYE DMQEITQHFA VCHVDAPGQQ DGAASFPAGY MYPSMDQLAE 120 MLPGVLQQFG LKSIIGMGTG AGAYILTRFA LNNPEMVEGL VLINVNPCAE GWMDWAASKI 180 SGWTQALPDM VVSHLFGKEE MQSNVEVVHT YRQHIVNDMN PGNLHLFINA YNSRRDLEIE 240 RPMPGTHTVT LQCPALLVVG DSSPAVDAVV ECNSKLDPTK TTLLKMADCG GLPQISQPAK 300 LAEAFKYFVQ GMGYMPSASM TRLMRSRTAS GSSVTSLDGT RSRSHTSEGT RSRSHTSEGT 360 RSRSHTSEGA HLDITPNSGA AGNSAGPKSM EVSC 395 |
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| Database | Annotation |
|---|---|
| Cancer Gene Census | prostate |
| CTD (Curated) (count: 19) (view all) | MESH:D001254
; Astrocytoma MESH:D001943 ; Breast Neoplasms MESH:D021441 ; Carcinoma, Pancreatic Ductal MESH:D002292 ; Carcinoma, Renal Cell MESH:C535575 ; Carcinoma, squamous cell of head and neck MESH:D005909 ; Glioblastoma |
| DisGeNet (Curated) (count: 43) (view all) | C0004114; Astrocytoma
C0007131; Non-Small Cell Lung Carcinoma C0007134; Renal Cell Carcinoma C0011053; Deafness C0017636; Glioblastoma C0018564; Hand deformities |
| HGMD (count: 2) | CM001817; Neuropathy, hereditary motor and sensory, Lom-type; Missense/nonsense
CS032077; Charcot-Marie-Tooth disease; Splicing |
| GWASdb (count: 8) (view all) | rs7843329; Multiple complex diseases; Null
rs16904873; Blood pressure; hypertension rs4590423; Multiple complex diseases; Null rs7018287; Job-related exhaustion; mood disorder|sleep disorder rs2272651; Post-traumatic stress disorder (asjusted for relatedness); post-traumatic stress disorder rs2272651; Post-traumatic stress disorder; post-traumatic stress disorder |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 32) (view all) | 2 ******MSREMQDVD dbPAF
319 MGYMPSASMTRLMRS dbPAF 321 YMPSASMTRLMRSRT dbPAF 326 SMTRLMRSRTASGSS dbPAF 328 TRLMRSRTASGSSVT dbPAF 330 LMRSRTASGSSVTSL dbPAF |
| Ubiquitination (count: 1) | 14 DVDLAEVKPLVEKGE PLMD |
| Sumoylation (count: 1) | 14 DVDLAEVKPLVEKGE PLMD |