Q92529

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession SHC3_HUMAN; Q92529;
Entrez ID 53358
GenBank Protein ID
GenBank Nucleotide ID
Protein Name SHC-transforming protein 3 (Neuronal Shc) (N-Shc) (Protein Rai) (SHC-transforming protein C) (Src homology 2 domain-containing-transforming protein C3) (SH2 domain protein C3)
Gene Name SHC3; NSHC; SHCC
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionSignaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.
Sequence
(Fasta)		MLPRTKYNRF RNDSVTSVDD LLHSLSVSGG GGKVSAARAT PAAAPYLVSG EALRKAPDDG 60
PGSLGHLLHK VSHLKLSSSG LRGLSSAARE RAGARLSGSC SAPSLAAPDG SAPSAPRAPA 120
MSAARKGRPG DEPLPRPPRG APHASDQVLG PGVTYVVKYL GCIEVLRSMR SLDFSTRTQI 180
TREAISRVCE AVPGAKGAFK KRKPPSKMLS SILGKSNLQF AGMSISLTIS TASLNLRTPD 240
SKQIIANHHM RSISFASGGD PDTTDYVAYV AKDPVNRRAC HILECCDGLA QDVIGSIGQA 300
FELRFKQYLQ CPTKIPALHD RMQSLDEPWT EEEGDGSDHP YYNSIPSKMP PPGGFLDTRL 360
KPRPHAPDTA QFAGKEQTYY QGRHLGDTFG EDWQQTPLRQ GSSDIYSTPE GKLHVAPTGE 420
APTYVNTQQI PPQAWPAAVS SAESSPRKDL FDMKPFEDAL KNQPLGPVLS KAASVECISP 480
VSPRAPDAKM LEELQAETWY QGEMSRKEAE GLLEKDGDFL VRKSTTNPGS FVLTGMHNGQ 540
AKHLLLVDPE GTIRTKDRVF DSISHLINHH LESSLPIVSA GSELCLQQPV ERKQ 595

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1PhosphorylationNeuroblastomaU15972965
[Reference]: The suppression of activated ALK in neuroblastoma cells by RNA interference significantly reduced the phosphorylation of ShcC, mitogen-activated protein kinases, and Akt, inducing rapid apoptosis in the cells.
2Tyrosine PhosphorylationNeuroblastomaUY40624349301
[Reference]: Increased in NB10 cells (MYCN amplified neuroblastoma line) compared to NPC cells (normal neural crest line)

※ Disease Cross-ref Annotation

DatabaseAnnotation
GWASdb
(count: 7)
(view all)		rs12115280; Personality dimensions; personality disorder
rs13295927; Alcohol dependence; alcohol dependence
rs13295927; Alcoholism; alcohol dependence
rs9410462; Suicide attempts in bipolar disorder; bipolar disorder
rs11137521; Urinary metabolites; kidney disease
rs17527693; Multiple complex diseases; Null

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 17)
(view all)		 210       KPPSKMLSSILGKSN     dbPAF
224       NLQFAGMSISLTIST     dbPAF
308       FELRFKQYLQCPTKI     dbPAF
324       ALHDRMQSLDEPWTE     dbPAF
337       TEEEGDGSDHPYYNS     dbPAF
341       GDGSDHPYYNSIPSK     dbPAF
Glycation
(count: 1)		 515       EAEGLLEKDGDFLVR     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource