Q92519

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession TRIB2_HUMAN; Q92519;
Entrez ID 28951
GenBank Protein ID
GenBank Nucleotide ID
Protein Name Tribbles homolog 2 (TRB-2)
Gene Name TRIB2; TRB2
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionInteracts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity (By similarity).
Sequence
(Fasta)
MNIHRSTPIT IARYGRSRNK TQDFEELSSI RSAEPSQSFS PNLGSPSPPE TPNLSHCVSC 60
IGKYLLLEPL EGDHVFRAVH LHSGEELVCK VFDISCYQES LAPCFCLSAH SNINQITEII 120
LGETKAYVFF ERSYGDMHSF VRTCKKLREE EAARLFYQIA SAVAHCHDGG LVLRDLKLRK 180
FIFKDEERTR VKLESLEDAY ILRGDDDSLS DKHGCPAYVS PEILNTSGSY SGKAADVWSL 240
GVMLYTMLVG RYPFHDIEPS SLFSKIRRGQ FNIPETLSPK AKCLIRSILR REPSERLTSQ 300
EILDHPWFST DFSVSNSAYG AKEVSDQLVP DVNMEENLDP FFN 344

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Serine PhosphorylationLiver cancertumor tissueDS8324089522
[Reference]: we found that TRIB2 was up-regulated and exhibited high stability in liver cancer cells compared with other cells.

※ Disease Cross-ref Annotation

DatabaseAnnotation
GWASdb
(count: 4)
rs6719434; Pericardial fat; myocardial infarction
rs2278117; Pericardial fat; myocardial infarction
rs2042567; Pericardial fat; myocardial infarction
rs2042566; Pericardial fat; myocardial infarction

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 10)
(view all)
133       AYVFFERSYGDMHSF     dbPAF
134       YVFFERSYGDMHSFV     dbPAF
139       RSYGDMHSFVRTCKK     dbPAF
14        TPITIARYGRSRNKT     dbPAF
143       DMHSFVRTCKKLREE     dbPAF
28        TQDFEELSSIRSAEP     dbPAF

※ Protein-Protein Interaction

NetworkInteraction
ABSource