Q91V14

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession S12A5_MOUSE; Q91V14;
Entrez ID 57138
GenBank Protein ID NM_020333.2; XM_006499943.3;
GenBank Nucleotide ID NP_065066.2; XP_006500006.2;
Protein Name Solute carrier family 12 member 5 (Electroneutral potassium-chloride cotransporter 2) (K-Cl cotransporter 2) (mKCC2) (Neuronal K-Cl cotransporter)
Gene Name Slc12a5; Kcc2; Kiaa1176
Organism Mus musculus
NCBI Taxa ID 10090
Functional DescriptionMediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl(-) homeostasis. As major extruder of intracellular chloride, it establishes the low neuronal Cl(-) levels required for chloride influx after binding of GABA-A and glycine to their receptors, with subsequent hyperpolarization and neuronal inhibition. Involved in the regulation of dendritic spine formation and maturation.
Sequence
(Fasta)		MSRRFTVTSL PPAASAASAD PESRRHSVAD PRRLPREDVK GDGNPKESSP FINSTDTEKG 60
REYDGRNMAL FEEEMDTSPM VSSLLSGLAN YTNLPQGSRE HEEAENNEGG KKKPVQAPRM 120
GTFMGVYLPC LQNIFGVILF LRLTWVVGIA GIMESFCMVF ICCSCTMLTA ISMSAIATNG 180
VVPAGGSYYM ISRSLGPEFG GAVGLCFYLG TTFAGAMYIL GTIEILLAYL FPAMAIFKAE 240
DASGEAAAML NNMRVYGTCV LTCMATVVFV GVKYVNKFAL VFLGCVILSI LAIYAGVIKS 300
AFDPPNFPIC LLGNRTLSRH GFDVCAKLAW EGNETVTTRL WGLFCSSRLL NATCDEYFTR 360
NNVTEIQGIP GAASGLIKEN LWSSYLTKGV IVERRGMPSV GLADGTPVDM DHPYVFSDMT 420
SYFTLLVGIY FPSVTGIMAG SNRSGDLRDA QKSIPTGTIL AIATTSAVYI SSVVLFGACI 480
EGVVLRDKFG EAVNGNLVVG TLAWPSPWVI VIGSFFSTCG AGLQSLTGAP RLLQAISRDG 540
IVPFLQVFGH GKANGEPTWA LLLTACICEI GILIASLDEV APILSMFFLM CYMFVNLACA 600
VQTLLRTPNW RPRFRYYHWT LSFLGMSLCL ALMFICSWYY ALVAMLIAGL IYKYIEYRGA 660
EKEWGDGIRG LSLSAARYAL LRLEEGPPHT KNWRPQLLVL VRVDQDQNVV HPQLLSLTSQ 720
LKAGKGLTIV GSVLEGTFLD NHPQAQRAEE SIRRLMEAEK VKGFCQVVIS SNLRDGVSHL 780
IQSGGLGGLQ HNTVLVGWPR NWRQKEDHQT WRNFIELVRE TTAGHLALLV TKNVSMFPGN 840
PERFSEGSID VWWIVHDGGM LMLLPFLLRH HKVWRKCKMR IFTVAQMDDN SIQMKKDLTT 900
FLYHLRITAE VEVVEMHESD ISAYTYEKTL VMEQRSQILK QMHLTKNERE REIQSITDES 960
RGSIRRKNPA NPRLRLNVPE ETACDNEEKP EEEVQLIHDQ SAPSCPSSSP SPGEEPEGER 1020
ETDPEVHLTW TKDKSVAEKN KGPSPVSSEG IKDFFSMKPE WENLNQSNVR RMHTAVRLNE 1080
VIVNKSRDAK LVLLNMPGPP RNRNGDENYM EFLEVLTEQL DRVMLVRGGG REVITIYS 1139

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Tyrosine PhosphorylationStatus epilepticusUY92620600929
[Reference]: Tyrosine phosphorylation regulates the membrane trafficking of the potassium chloride co-transporter KCC2.
2Serine PhosphorylationStatus epilepticusDS96325733865
[Reference]: KCC2 activity is critical in limiting the onset and severity of status epilepticus.

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 7)
(view all)		MESH:D004827 ; Epilepsy
MESH:C562694 ; Epilepsy, Idiopathic Generalized
MESH:D004833 ; Epilepsy, Temporal Lobe
OMIM:616645 ; EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 34
MESH:D006930 ; Hyperalgesia
MESH:D013226 ; Status Epilepticus

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 24)
(view all)		 1011      SCPSSSPSPGEEPEG     dbPAF
1022      EPEGERETDPEVHLT     dbPAF
1029      TDPEVHLTWTKDKSV     dbPAF
1031      PEVHLTWTKDKSVAE     dbPAF
1044      AEKNKGPSPVSSEGI     dbPAF
1047      NKGPSPVSSEGIKDF     dbPAF
Ubiquitination
(count: 10)
(view all)		 1041      KSVAEKNKGPSPVSS     PLMD
1052      PVSSEGIKDFFSMKP     PLMD
1058      IKDFFSMKPEWENLN     PLMD
1085      LNEVIVNKSRDAKLV     PLMD
1090      VNKSRDAKLVLLNMP     PLMD
388       LWSSYLTKGVIVERR     PLMD