Q8WYL5

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession SSH1_HUMAN; Q8WYL5;
Entrez ID 54434
GenBank Protein ID NM_001161330.1; NM_001161331.1; NM_018984.3; XM_017019493.1; XM_017019494.1;
GenBank Nucleotide ID NP_001154802.1; NP_001154803.1; NP_061857.3; XP_016874982.1; XP_016874983.1;
Protein Name Protein phosphatase Slingshot homolog 1 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 1) (SSH-1L) (hSSH-1L)
Gene Name SSH1; KIAA1298; SSH1L
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionProtein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein.
Sequence
(Fasta)
MALVTLQRSP TPSAASSSAS NSELEAGSEE DRKLNLSLSE SFFMVKGAAL FLQQGSSPQG 60
QRSLQHPHKH AGDLPQHLQV MINLLRCEDR IKLAVRLESA WADRVRYMVV VYSSGRQDTE 120
ENILLGVDFS SKESKSCTIG MVLRLWSDTK IHLDGDGGFS VSTAGRMHIF KPVSVQAMWS 180
ALQVLHKACE VARRHNYFPG GVALIWATYY ESCISSEQSC INEWNAMQDL ESTRPDSPAL 240
FVDKPTEGER TERLIKAKLR SIMMSQDLEN VTSKEIRNEL EKQMNCNLKE LKEFIDNEML 300
LILGQMDKPS LIFDHLYLGS EWNASNLEEL QGSGVDYILN VTREIDNFFP GLFAYHNIRV 360
YDEETTDLLA HWNEAYHFIN KAKRNHSKCL VHCKMGVSRS ASTVIAYAMK EFGWPLEKAY 420
NYVKQKRSIT RPNAGFMRQL SEYEGILDAS KQRHNKLWRQ QTDSSLQQPV DDPAGPGDFL 480
PETPDGTPES QLPFLDDAAQ PGLGPPLPCC FRRLSDPLLP SPEDETGSLV HLEDPEREAL 540
LEEAAPPAEV HRPARQPQQG SGLCEKDVKK KLEFGSPKGR SGSLLQVEET EREEGLGAGR 600
WGQLPTQLDQ NLLNSENLNN NSKRSCPNGM EDDAIFGILN KVKPSYKSCA DCMYPTASGA 660
PEASRERCED PNAPAICTQP AFLPHITSSP VAHLASRSRV PEKPASGPTE PPPFLPPAGS 720
RRADTSGPGA GAALEPPASL LEPSRETPKV LPKSLLLKNS HCDKNPPSTE VVIKEESSPK 780
KDMKPAKDLR LLFSNESEKP TTNSYLMQHQ ESIIQLQKAG LVRKHTKELE RLKSVPADPA 840
PPSRDGPASR LEASIPEESQ DPAALHELGP LVMPSQAGSD EKSEAAPASL EGGSLKSPPP 900
FFYRLDHTSS FSKDFLKTIC YTPTSSSMSS NLTRSSSSDS IHSVRGKPGL VKQRTQEIET 960
RLRLAGLTVS SPLKRSHSLA KLGSLTFSTE DLSSEADPST VADSQDTTLS ESSFLHEPQG 1020
TPRDPAATSK PSGKPAPENL KSPSWMSKS

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Serine PhosphorylationBreast cancer/tumor/carcinomaMCF-7 cell linePS97823148218
[Reference]: SSH1L Phosphorylation at Ser-978 Affects Directed MCF-7 Cell Migration

※ Disease Cross-ref Annotation

DatabaseAnnotation
HGMD
(count: 1)
CM043342; Porokeratosis, disseminated superficial actinic, 1; Missense/nonsense
GWASdb
(count: 5)
rs3741781; Cognitive impairment induced by topiramate; cognitive disorder
rs1549087; Alzheimer's disease; Alzheimer's disease
rs12424287; Alzheimer's disease; Alzheimer's disease
rs11114068; Type 2 diabetes; type 2 diabetes mellitus
rs11114068; Alzheimer's disease; Alzheimer's disease

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 58)
(view all)
1021      FLHEPQGTPRDPAAT     dbPAF
1042      PAPENLKSPSWMSKS     dbPAF
1049      SPSWMSKS*******     dbPAF
11        VTLQRSPTPSAASSS     dbPAF
112       VRYMVVVYSSGRQDT     dbPAF
113       RYMVVVYSSGRQDTE     dbPAF
Glycation
(count: 3)
46        SESFFMVKGAALFLQ     PLMD
69        RSLQHPHKHAGDLPQ     PLMD
896       SLEGGSLKSPPPFFY     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource