Tag | Content |
---|---|
UniProt Accession | SSH1_HUMAN; Q8WYL5; |
Entrez ID | 54434 |
GenBank Protein ID | NM_001161330.1; NM_001161331.1; NM_018984.3; XM_017019493.1; XM_017019494.1; |
GenBank Nucleotide ID | NP_001154802.1; NP_001154803.1; NP_061857.3; XP_016874982.1; XP_016874983.1; |
Protein Name | Protein phosphatase Slingshot homolog 1 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 1) (SSH-1L) (hSSH-1L) |
Gene Name | SSH1; KIAA1298; SSH1L |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein. |
Sequence (Fasta) | MALVTLQRSP TPSAASSSAS NSELEAGSEE DRKLNLSLSE SFFMVKGAAL FLQQGSSPQG 60 QRSLQHPHKH AGDLPQHLQV MINLLRCEDR IKLAVRLESA WADRVRYMVV VYSSGRQDTE 120 ENILLGVDFS SKESKSCTIG MVLRLWSDTK IHLDGDGGFS VSTAGRMHIF KPVSVQAMWS 180 ALQVLHKACE VARRHNYFPG GVALIWATYY ESCISSEQSC INEWNAMQDL ESTRPDSPAL 240 FVDKPTEGER TERLIKAKLR SIMMSQDLEN VTSKEIRNEL EKQMNCNLKE LKEFIDNEML 300 LILGQMDKPS LIFDHLYLGS EWNASNLEEL QGSGVDYILN VTREIDNFFP GLFAYHNIRV 360 YDEETTDLLA HWNEAYHFIN KAKRNHSKCL VHCKMGVSRS ASTVIAYAMK EFGWPLEKAY 420 NYVKQKRSIT RPNAGFMRQL SEYEGILDAS KQRHNKLWRQ QTDSSLQQPV DDPAGPGDFL 480 PETPDGTPES QLPFLDDAAQ PGLGPPLPCC FRRLSDPLLP SPEDETGSLV HLEDPEREAL 540 LEEAAPPAEV HRPARQPQQG SGLCEKDVKK KLEFGSPKGR SGSLLQVEET EREEGLGAGR 600 WGQLPTQLDQ NLLNSENLNN NSKRSCPNGM EDDAIFGILN KVKPSYKSCA DCMYPTASGA 660 PEASRERCED PNAPAICTQP AFLPHITSSP VAHLASRSRV PEKPASGPTE PPPFLPPAGS 720 RRADTSGPGA GAALEPPASL LEPSRETPKV LPKSLLLKNS HCDKNPPSTE VVIKEESSPK 780 KDMKPAKDLR LLFSNESEKP TTNSYLMQHQ ESIIQLQKAG LVRKHTKELE RLKSVPADPA 840 PPSRDGPASR LEASIPEESQ DPAALHELGP LVMPSQAGSD EKSEAAPASL EGGSLKSPPP 900 FFYRLDHTSS FSKDFLKTIC YTPTSSSMSS NLTRSSSSDS IHSVRGKPGL VKQRTQEIET 960 RLRLAGLTVS SPLKRSHSLA KLGSLTFSTE DLSSEADPST VADSQDTTLS ESSFLHEPQG 1020 TPRDPAATSK PSGKPAPENL KSPSWMSKS |
|
Database | Annotation |
---|---|
HGMD (count: 1) | CM043342; Porokeratosis, disseminated superficial actinic, 1; Missense/nonsense
|
GWASdb (count: 5) | rs3741781; Cognitive impairment induced by topiramate; cognitive disorder
rs1549087; Alzheimer's disease; Alzheimer's disease rs12424287; Alzheimer's disease; Alzheimer's disease rs11114068; Type 2 diabetes; type 2 diabetes mellitus rs11114068; Alzheimer's disease; Alzheimer's disease |
PTM | Modification Sites |
---|---|
Phosphorylation (count: 58) (view all) | 1021 FLHEPQGTPRDPAAT dbPAF
1042 PAPENLKSPSWMSKS dbPAF 1049 SPSWMSKS******* dbPAF 11 VTLQRSPTPSAASSS dbPAF 112 VRYMVVVYSSGRQDT dbPAF 113 RYMVVVYSSGRQDTE dbPAF |
Glycation (count: 3) | 46 SESFFMVKGAALFLQ PLMD
69 RSLQHPHKHAGDLPQ PLMD 896 SLEGGSLKSPPPFFY PLMD |
Network | Interaction | ||
---|---|---|---|
A | B | Source | |