Q8VI36

※ Protein Information

Tag	Content
UniProt Accession	PAXI_MOUSE; Q8VI36;
Entrez ID	19303
GenBank Protein ID	NM_011223.3; NM_133915.3;
GenBank Nucleotide ID	NP_035353.1; NP_598676.2;
Protein Name	Paxillin
Gene Name	Pxn
Organism	Mus musculus
NCBI Taxa ID	10090
Functional Description	Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Functional Description Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion).
Sequence (Fasta)	MDDLDALLAD LESTTSHISK RPVFLSEEPP YSYPTGNHTY QEIAVPPPVP PPPSSEALNG 60 TVLDPLDQWQ PSGSRYAHQQ PPSPLPVYSS SAKNSSASNT QDGVGSLCSR AGEEEHVYSF 120 PNKQKSAEPS PTVMSSSLGS NLSELDRLLL ELNAVQHSPP GFPADEAESS PPLPGALSPL 180 YGIPENNTPL GGKAGPLVKE KPKRNGGRGL EDVRPSVESL LDELESSVPS PVPAITVNQG 240 EMSSPQRVTS SQQQTRISAS SATRELDELM ASLSDFKMQG LEQRVDGERP WAAGWPPSSR 300 QSSPEGQDEG GFMAQGKTGS SSPPGGLSKP GSQLDSMLGS LQSDLNKLGV ATVAKGVCGA 360 CKKPIAGQVV TAMGKTWHPE HFVCTHCQEE IGSRNFFERD GQPYCEKDYH SLFSPRCYYC 420 NGPILDKVVT ALDRTWHPEH FFCAQCGAFF GPEGFHEKDG KAYCRKDYFD MFAPKCGGCA 480 RAILENYISA LNTLWHPECF VCRECFTPFV NGSFFEHDGQ PYCEVHYHER RGSLCSGCQK 540 PITGRCITAM AKKFHPEHFV CAFCLKQLNK GTFKEQNDKP YCQSCFVKLF C 592 Fasta Sequence >Q8VI36\|Pxn\|Mus musculus (Mouse) MDDLDALLADLESTTSHISKRPVFLSEEPPYSYPTGNHTYQEIAVPPPVPPPPSSEALNGTVLDPLDQWQPSGSRYAHQQPPSPLPVYSSSAKNSSASNTQDGVGSLCSRAGEEEHVYSFPNKQKSAEPSPTVMSSSLGSNLSELDRLLLELNAVQHSPPGFPADEAESSPPLPGALSPLYGIPENNTPLGGKAGPLVKEKPKRNGGRGLEDVRPSVESLLDELESSVPSPVPAITVNQGEMSSPQRVTSSQQQTRISASSATRELDELMASLSDFKMQGLEQRVDGERPWAAGWPPSSRQSSPEGQDEGGFMAQGKTGSSSPPGGLSKPGSQLDSMLGSLQSDLNKLGVATVAKGVCGACKKPIAGQVVTAMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHSLFSPRCYYCNGPILDKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFDMFAPKCGGCARAILENYISALNTLWHPECFVCRECFTPFVNGSFFEHDGQPYCEVHYHERRGSLCSGCQKPITGRCITAMAKKFHPEHFVCAFCLKQLNKGTFKEQNDKPYCQSCFVKLFC

※ PTM-Disease Association

Num	PTM	Disease	Type	PTM Site	PMID
1	Serine Phosphorylation	Lewis lung carcinoma	U	S	12198769
1	[Reference]: Protein phosphatase-2A modulates the serine and tyrosine phosphorylation of paxillin in Lewis lung carcinoma tumor variants
2	Tyrosine Phosphorylation	Colon cancer/carcinoma	U	Y88	20133777
2	[Reference]: PTPRT knockout mice that we generated exhibit increased levels of colonic paxillin phosphorylation at residue Y88 and are highly susceptible to carcinogen azoxymethane-induced colon tumor, providing critical in vivo evidence that PTPRT normally functions as a tumor suppressor. Moreover, similarly increased paxillin pY88 is also found as a common feature of human colon cancers.?
3	Serine Phosphorylation	Neuroblastoma	P	S178	18486129
3	[Reference]: We previously demonstrated that c-Jun N-terminal kinase (JNK) phosphorylation of the focal adhesion protein paxillin mediates differentiation in N1E-115 neuroblastoma cells.

※ Disease Cross-ref Annotation

Database	Annotation
CTD (Curated) (count: 4)	MESH:D002471 ; Cell Transformation, Neoplastic MESH:D008546 ; Melanoma, Experimental MESH:D009362 ; Neoplasm Metastasis MESH:D002289 ; Carcinoma, Non-Small-Cell Lung

※ PTM Sites

PTM	Modification Sites
Phosphorylation (count: 55) (view all)	106 NTQDGVGSLCSRAGE dbPAF 109 DGVGSLCSRAGEEEH dbPAF 118 AGEEEHVYSFPNKQK dbPAF 119 GEEEHVYSFPNKQKS dbPAF 126 SFPNKQKSAEPSPTV dbPAF 130 KQKSAEPSPTVMSSS dbPAF 132 KSAEPSPTVMSSSLG dbPAF 135 EPSPTVMSSSLGSNL dbPAF 136 PSPTVMSSSLGSNLS dbPAF 137 SPTVMSSSLGSNLSE dbPAF 140 VMSSSLGSNLSELDR dbPAF 143 SSLGSNLSELDRLLL dbPAF 158 ELNAVQHSPPGFPAD dbPAF 169 FPADEAESSPPLPGA dbPAF 170 PADEAESSPPLPGAL dbPAF 178 PPLPGALSPLYGIPE dbPAF 181 PGALSPLYGIPENNT dbPAF 244 VNQGEMSSPQRVTSS dbPAF 250 SSPQRVTSSQQQTRI dbPAF 251 SPQRVTSSQQQTRIS dbPAF 258 SQQQTRISASSATRE dbPAF 26 SKRPVFLSEEPPYSY dbPAF 260 QQTRISASSATRELD dbPAF 261 QTRISASSATRELDE dbPAF 263 RISASSATRELDELM dbPAF 272 ELDELMASLSDFKMQ dbPAF 302 WPPSSRQSSPEGQDE dbPAF 303 PPSSRQSSPEGQDEG dbPAF 31 FLSEEPPYSYPTGNH dbPAF 318 GFMAQGKTGSSSPPG dbPAF 32 LSEEPPYSYPTGNHT dbPAF 320 MAQGKTGSSSPPGGL dbPAF 321 AQGKTGSSSPPGGLS dbPAF 322 QGKTGSSSPPGGLSK dbPAF 328 SSPPGGLSKPGSQLD dbPAF 33 SEEPPYSYPTGNHTY dbPAF 332 GGLSKPGSQLDSMLG dbPAF 336 KPGSQLDSMLGSLQS dbPAF 340 QLDSMLGSLQSDLNK dbPAF 343 SMLGSLQSDLNKLGV dbPAF 39 SYPTGNHTYQEIAVP dbPAF 40 YPTGNHTYQEIAVPP dbPAF 409 QPYCEKDYHSLFSPR dbPAF 414 KDYHSLFSPRCYYCN dbPAF 468 KAYCRKDYFDMFAPK dbPAF 533 HYHERRGSLCSGCQK dbPAF 543 SGCQKPITGRCITAM dbPAF 572 LKQLNKGTFKEQNDK dbPAF 76 WQPSGSRYAHQQPPS dbPAF 83 YAHQQPPSPLPVYSS dbPAF 88 PPSPLPVYSSSAKNS dbPAF 89 PSPLPVYSSSAKNSS dbPAF 90 SPLPVYSSSAKNSSA dbPAF 91 PLPVYSSSAKNSSAS dbPAF 96 SSSAKNSSASNTQDG dbPAF
Ubiquitination (count: 5)	125 YSFPNKQKSAEPSPT PLMD 363 GVCGACKKPIAGQVV PLMD 407 DGQPYCEKDYHSLFS PLMD 466 DGKAYCRKDYFDMFA PLMD 540 SLCSGCQKPITGRCI PLMD

PTM

Modification Sites

Phosphorylation
(count: 55)
(view all)

106       NTQDGVGSLCSRAGE     dbPAF
109       DGVGSLCSRAGEEEH     dbPAF
118       AGEEEHVYSFPNKQK     dbPAF
119       GEEEHVYSFPNKQKS     dbPAF
126       SFPNKQKSAEPSPTV     dbPAF
130       KQKSAEPSPTVMSSS     dbPAF

Ubiquitination
(count: 5)

125       YSFPNKQKSAEPSPT     PLMD
363       GVCGACKKPIAGQVV     PLMD
407       DGQPYCEKDYHSLFS     PLMD
466       DGKAYCRKDYFDMFA     PLMD
540       SLCSGCQKPITGRCI     PLMD

※ Protein-Protein Interaction

Network

Interaction

Source

D3Z2P2	Q8VI36	MINT
E9PVA6	Q8VI36	MINT
P11627	Q8VI36	MINT
P34152	Q8VI36	IntAct; MINT
P35235	Q8VI36	MINT
P41241	Q8VI36	MINT
P54763	Q8VI36	IntAct
P70196	Q8VI36	IntAct
Q3TZW9	Q8VI36	MINT
Q5F258	Q8VI36	MINT
Q62417	Q8VI36	MINT
Q64010	Q8VI36	MINT
Q8VI36	Q9QWY8	MINT
Q8VI36	Q9QYY0	MINT

PTMD Annotation Information

※ Protein Information

Functional Description

Fasta Sequence

※ PTM-Disease Association

※ Disease Cross-ref Annotation

※ PTM Sites

※ Protein-Protein Interaction