| Tag | Content |
|---|---|
| UniProt Accession | PREX1_HUMAN; Q8TCU6; |
| Entrez ID | 57580 |
| GenBank Protein ID | |
| GenBank Nucleotide ID | |
| Protein Name | Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1) (PtdIns(3,4,5)-dependent Rac exchanger 1) |
| Gene Name | PREX1; KIAA1415 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils. |
| Sequence (Fasta) | MEAPSGSEPG GDGAGDCAHP DPRAPGAAAP SSGPGPCAAA RESERQLRLR LCVLNEILGT 60 ERDYVGTLRF LQSAFLHRIR QNVADSVEKG LTEENVKVLF SNIEDILEVH KDFLAALEYC 120 LHPEPQSQHE LGNVFLKFKD KFCVYEEYCS NHEKALRLLV ELNKIPTVRA FLLSCMLLGG 180 RKTTDIPLEG YLLSPIQRIC KYPLLLKELA KRTPGKHPDH PAVQSALQAM KTVCSNINET 240 KRQMEKLEAL EQLQSHIEGW EGSNLTDICT QLLLQGTLLK ISAGNIQERA FFLFDNLLVY 300 CKRKSRVTGS KKSTKRTKSI NGSLYIFRGR INTEVMEVEN VEDGTADYHS NGYTVTNGWK 360 IHNTAKNKWF VCMAKTAEEK QKWLDAIIRE REQRESLKLG MERDAYVMIA EKGEKLYHMM 420 MNKKVNLIKD RRRKLSTVPK CFLGNEFVAW LLEIGEISKT EEGVNLGQAL LENGIIHHVS 480 DKHQFKNEQV MYRFRYDDGT YKARSELEDI MSKGVRLYCR LHSLYTPVIK DRDYHLKTYK 540 SVLPGSKLVD WLLAQGDCQT REEAVALGVG LCNNGFMHHV LEKSEFRDES QYFRFHADEE 600 MEGTSSKNKQ LRNDFKLVEN ILAKRLLILP QEEDYGFDIE EKNKAVVVKS VQRGSLAEVA 660 GLQVGRKIYS INEDLVFLRP FSEVESILNQ SFCSRRPLRL LVATKAKEII KIPDQPDTLC 720 FQIRGAAPPY VYAVGRGSEA MAAGLCAGQC ILKVNGSNVM NDGAPEVLEH FQAFRSRREE 780 ALGLYQWIYH THEDAQEARA SQEASTEDPS GEQAQEEDQA DSAFPLLSLG PRLSLCEDSP 840 MVTLTVDNVH LEHGVVYEYV STAGVRCHVL EKIVEPRGCF GLTAKILEAF AANDSVFVEN 900 CRRLMALSSA IVTMPHFEFR NICDTKLESI GQRIACYQEF AAQLKSRVSP PFKQAPLEPH 960 PLCGLDFCPT NCHINLMEVS YPKTTPSVGR SFSIRFGRKP SLIGLDPEQG HLNPMSYTQH 1020 CITTMAAPSW KCLPAAEGDP QGQGLHDGSF GPASGTLGQE DRGLSFLLKQ EDREIQDAYL 1080 QLFTKLDVAL KEMKQYVTQI NRLLSTITEP TSGGSCDASL AEEASSLPLV SEESEMDRSD 1140 HGGIKKVCFK VAEEDQEDSG HDTMSYRDSY SECNSNRDSV LSYTSVRSNS SYLGSDEMGS 1200 GDELPCDMRI PSDKQDKLHG CLEHLFNQVD SINALLKGPV MSRAFEETKH FPMNHSLQEF 1260 KQKEECTIRG RSLIQISIQE DPWNLPNSIK TLVDNIQRYV EDGKNQLLLA LLKCTDTELQ 1320 LRRDAIFCQA LVAAVCTFSK QLLAALGYRY NNNGEYEESS RDASRKWLEQ VAATGVLLHC 1380 QSLLSPATVK EERTMLEDIW VTLSELDNVT FSFKQLDENY VANTNVFYHI EGSRQALKVI 1440 FYLDSYHFSK LPSRLEGGAS LRLHTALFTK VLENVEGLPS PGSQAAEDLQ QDINAQSLEK 1500 VQQYYRKLRA FYLERSNLPT DASTTAVKID QLIRPINALD ELCRLMKSFV HPKPGAAGSV 1560 GAGLIPISSE LCYRLGACQM VMCGTGMQRS TLSVSLEQAA ILARSHGLLP KCIMQATDIM 1620 RKQGPRVEIL AKNLRVKDQM PQGAPRLYRL CQPPVDGDL |
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| Database | Annotation |
|---|---|
| GWASdb (count: 24) (view all) | rs4809712; Tourette syndrome; Gilles de la Tourette syndrome|obsessive-compulsive disorder|attention deficit hyperactivity disorder
rs4596036; Longevity; Null rs761272; Hypertension (early onset hypertension); hypertension rs6095248; Type 2 diabetes; type 2 diabetes mellitus rs926629; Hypertension (early onset hypertension); hypertension rs968479; Hypertension (early onset hypertension); hypertension |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 25) (view all) | 1001 IRFGRKPSLIGLDPE dbPAF
1049 GQGLHDGSFGPASGT dbPAF 1125 ASLAEEASSLPLVSE dbPAF 1159 AEEDQEDSGHDTMSY dbPAF 1165 DSGHDTMSYRDSYSE dbPAF 1166 SGHDTMSYRDSYSEC dbPAF |
| Acetylation (count: 1) | 241 CSNINETKRQMEKLE PLMD |
| Ubiquitination (count: 9) (view all) | 1069 RGLSFLLKQEDREIQ PLMD
182 CMLLGGRKTTDIPLE PLMD 201 SPIQRICKYPLLLKE PLMD 241 CSNINETKRQMEKLE PLMD 624 LVENILAKRLLILPQ PLMD 649 KNKAVVVKSVQRGSL PLMD |
| Glycation (count: 2) | 1217 IPSDKQDKLHGCLEH PLMD
1237 DSINALLKGPVMSRA PLMD |
| Network | Interaction | ||
|---|---|---|---|
| A | B | Source | |