Tag | Content |
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UniProt Accession | STT3B_HUMAN; Q8TCJ2; |
Entrez ID | 201595 |
GenBank Protein ID | |
GenBank Nucleotide ID | |
Protein Name | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B (Oligosaccharyl transferase subunit STT3B) (STT3-B) (EC 2.4.99.18) (Source of immunodominant MHC-associated peptides homolog) |
Gene Name | STT3B; SIMP |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Catalytic subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). STT3B is present in a small subset of OST complexes and mediates both cot(view all) |
Sequence (Fasta) | MAEPSAPESK HKSSLNSSPW SGLMALGNSR HGHHGPGAQC AHKAAGGAAP PKPAPAGLSG 60 GLSQPAGWQS LLSFTILFLA WLAGFSSRLF AVIRFESIIH EFDPWFNYRS THHLASHGFY 120 EFLNWFDERA WYPLGRIVGG TVYPGLMITA GLIHWILNTL NITVHIRDVC VFLAPTFSGL 180 TSISTFLLTR ELWNQGAGLL AACFIAIVPG YISRSVAGSF DNEGIAIFAL QFTYYLWVKS 240 VKTGSVFWTM CCCLSYFYMV SAWGGYVFII NLIPLHVFVL LLMQRYSKRV YIAYSTFYIV 300 GLILSMQIPF VGFQPIRTSE HMAAAGVFAL LQAYAFLQYL RDRLTKQEFQ TLFFLGVSLA 360 AGAVFLSVIY LTYTGYIAPW SGRFYSLWDT GYAKIHIPII ASVSEHQPTT WVSFFFDLHI 420 LVCTFPAGLW FCIKNINDER VFVALYAISA VYFAGVMVRL MLTLTPVVCM LSAIAFSNVF 480 EHYLGDDMKR ENPPVEDSSD EDDKRNQGNL YDKAGKVRKH ATEQEKTEEG LGPNIKSIVT 540 MLMLMLLMMF AVHCTWVTSN AYSSPSVVLA SYNHDGTRNI LDDFREAYFW LRQNTDEHAR 600 VMSWWDYGYQ IAGMANRTTL VDNNTWNNSH IALVGKAMSS NETAAYKIMR TLDVDYVLVI 660 FGGVIGYSGD DINKFLWMVR IAEGEHPKDI RESDYFTPQG EFRVDKAGSP TLLNCLMYKM 720 SYYRFGEMQL DFRTPPGFDR TRNAEIGNKD IKFKHLEEAF TSEHWLVRIY KVKAPDNRET 780 LDHKPRVTNI FPKQKYLSKK TTKRKRGYIK NKLVFKKGKK ISKKTV 827 |
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Database | Annotation |
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CTD (Curated) (count: 1) | OMIM:615597 ; CONGENITAL DISORDER OF GLYCOSYLATION, TYPE Ix |
DisGeNet (Curated) (count: 1) | C3810067; CONGENITAL DISORDER OF GLYCOSYLATION, TYPE Ix |
PTM | Modification Sites |
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Phosphorylation (count: 16) (view all) | 13 APESKHKSSLNSSPW dbPAF
14 PESKHKSSLNSSPWS dbPAF 17 KHKSSLNSSPWSGLM dbPAF 18 HKSSLNSSPWSGLMA dbPAF 21 SLNSSPWSGLMALGN dbPAF 29 GLMALGNSRHGHHGP dbPAF |
Acetylation (count: 3) | 10 EPSAPESKHKSSLNS PLMD
513 NQGNLYDKAGKVRKH PLMD 754 GNKDIKFKHLEEAFT PLMD |
Ubiquitination (count: 18) (view all) | 10 EPSAPESKHKSSLNS PLMD
12 SAPESKHKSSLNSSP PLMD 504 DSSDEDDKRNQGNLY PLMD 513 NQGNLYDKAGKVRKH PLMD 516 NLYDKAGKVRKHATE PLMD 526 KHATEQEKTEEGLGP PLMD |
Network | Interaction | ||
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A | B | Source | |