Tag | Content |
---|---|
UniProt Accession | SIR6_HUMAN; Q8N6T7; |
Entrez ID | 51548 |
GenBank Protein ID | NM_001193285.2; NM_001321058.1; NM_001321059.1; NM_001321060.1; NM_001321061.1; NM_001321062.1; NM_001321063.1; NM_001321064.1; NM_016539.3; |
GenBank Nucleotide ID | NP_001180214.1; NP_001307987.1; NP_001307988.1; NP_001307989.1; NP_001307990.1; NP_001307991.1; NP_001307992.1; NP_001307993.1; NP_057623.2; |
Protein Name | NAD-dependent protein deacetylase sirtuin-6 (EC 3.5.1.-) (Regulatory protein SIR2 homolog 6) (SIR2-like protein 6) |
Gene Name | SIRT6; SIR2L6 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has (view all) |
Sequence (Fasta) | MSVNYAAGLS PYADKGKCGL PEIFDPPEEL ERKVWELARL VWQSSSVVFH TGAGISTASG 60 IPDFRGPHGV WTMEERGLAP KFDTTFESAR PTQTHMALVQ LERVGLLRFL VSQNVDGLHV 120 RSGFPRDKLA ELHGNMFVEE CAKCKTQYVR DTVVGTMGLK ATGRLCTVAK ARGLRACRGE 180 LRDTILDWED SLPDRDLALA DEASRNADLS ITLGTSLQIR PSGNLPLATK RRGGRLVIVN 240 LQPTKHDRHA DLRIHGYVDE VMTRLMKHLG LEIPAWDGPR VLERALPPLP RPPTPKLEPK 300 EESPTRINGS IPAGPKQEPC AQHNGSEPAS PKRERPTSPA PHRPPKRVKA KAVPS 356 |
|
Database | Annotation |
---|---|
CTD (Curated) (count: 1) | MESH:D006332 ; Cardiomegaly |
PTM | Modification Sites |
---|---|
Phosphorylation (count: 12) (view all) | 10 VNYAAGLSPYADKGK dbPAF
146 EECAKCKTQYVRDTV dbPAF 148 CAKCKTQYVRDTVVG dbPAF 162 GTMGLKATGRLCTVA dbPAF 294 PPLPRPPTPKLEPKE dbPAF 303 KLEPKEESPTRINGS dbPAF |
Acetylation (count: 1) | 170 GRLCTVAKARGLRAC PLMD |
Ubiquitination (count: 8) (view all) | 128 RSGFPRDKLAELHGN PLMD
15 GLSPYADKGKCGLPE PLMD 160 VVGTMGLKATGRLCT PLMD 17 SPYADKGKCGLPEIF PLMD 170 GRLCTVAKARGLRAC PLMD 245 IVNLQPTKHDRHADL PLMD |
Network | Interaction | ||
---|---|---|---|
A | B | Source | |