Tag | Content |
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UniProt Accession | NIN_HUMAN; Q8N4C6; |
Entrez ID | 51199 |
GenBank Protein ID | NM_016350.4; NM_020921.3; NM_182944.2; NM_182946.1; XM_011536823.2; |
GenBank Nucleotide ID | NP_057434.4; NP_065972.3; NP_891989.2; NP_891991.1; XP_011535125.1; |
Protein Name | Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein) |
Gene Name | NIN; KIAA1565 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Centrosomal protein required in the positioning and anchorage of the microtubule minus-end in epithelial cells. May also act as a centrosome maturation factor. May play a role in microtubule nucleation. Overexpression does not perturb nucleation or elongation of microtubules but suppresses release of microtubules (PubMed:15190203). Required for centriole organization and microtubule anchoring at the mother centriole (PubMed:23386061). |
Sequence (Fasta) | MDEVEQDQHE ARLKELFDSF DTTGTGSLGQ EELTDLCHML SLEEVAPVLQ QTLLQDNLLG 60 RVHFDQFKEA LILILSRTLS NEEHFQEPDC SLEAQPKYVR GGKRYGRRSL PEFQESVEEF 120 PEVTVIEPLD EEARPSHIPA GDCSEHWKTQ RSEEYEAEGQ LRFWNPDDLN ASQSGSSPPQ 180 DWIEEKLQEV CEDLGITRDG HLNRKKLVSI CEQYGLQNVD GEMLEEVFHN LDPDGTMSVE 240 DFFYGLFKNG KSLTPSASTP YRQLKRHLSM QSFDESGRRT TTSSAMTSTI GFRVFSCLDD 300 GMGHASVERI LDTWQEEGIE NSQEILKALD FSLDGNINLT ELTLALENEL LVTKNSIHQA 360 ALASFKAEIR HLLERVDQVV REKEKLRSDL DKAEKLKSLM ASEVDDHHAA IERRNEYNLR 420 KLDEEYKERI AALKNELRKE REQILQQAGK QRLELEQEIE KAKTEENYIR DRLALSLKEN 480 SRLENELLEN AEKLAEYENL TNKLQRNLEN VLAEKFGDLD PSSAEFFLQE ERLTQMRNEY 540 ERQCRVLQDQ VDELQSELEE YRAQGRVLRL PLKNSPSEEV EANSGGIEPE HGLGSEECNP 600 LNMSIEAELV IEQMKEQHHR DICCLRLELE DKVRHYEKQL DETVVSCKKA QENMKQRHEN 660 ETHTLEKQIS DLKNEIAELQ GQAAVLKEAH HEATCRHEEE KKQLQVKLEE EKTHLQEKLR 720 LQHEMELKAR LTQAQASFER EREGLQSSAW TEEKVRGLTQ ELEQFHQEQL TSLVEKHTLE 780 KEELRKELLE KHQRELQEGR EKMETECNRR TSQIEAQFQS DCQKVTERCE SALQSLEGRY 840 RQELKDLQEQ QREEKSQWEF EKDELTQECA EAQELLKETL KREKTTSLVL TQEREMLEKT 900 YKEHLNSMVV ERQQLLQDLE DLRNVSETQQ SLLSDQILEL KSSHKRELRE REEVLCQAGA 960 SEQLASQRLE RLEMEHDQER QEMMSKLLAM ENIHKATCET ADRERAEMST EISRLQSKIK 1020 EMQQATSPLS MLQSGCQVIG EEEVEGDGAL SLLQQGEQLL EENGDVLLSL QRAHEQAVKE 1080 NVKMATEISR LQQRLQKLEP GLVMSSCLDE PATEFFGNTA EQTEQFLQQN RTKQVEGVTR 1140 RHVLSDLEDD EVRDLGSTGT SSVQRQEVKI EESEASVEGF SELENSEETR TESWELKNQI 1200 SQLQEQLMML CADCDRASEK KQDLLFDVSV LKKKLKMLER IPEASPKYKL LYEDVSREND 1260 CLQEELRMME TRYDEALENN KELTAEVFRL QDELKKMEEV TETFLSLEKS YDEVKIENEG 1320 LNVLVLRLQG KIEKLQESVV QRCDCCLWEA SLENLEIEPD GNILQLNQTL EECVPRVRSV 1380 HHVIEECKQE NQYLEGNTQL LEKVKAHEIA WLHGTIQTHQ ERPRVQNQVI LEENTTLLGF 1440 QDKHFQHQAT IAELELEKTK LQELTRKLKE RVTILVKQKD VLSHGEKEEE LKAMMHDLQI 1500 TCSEMQQKVE LLRYESEKLQ QENSILRNEI TTLNEEDSIS NLKLGTLNGS QEEMWQKTET 1560 VKQENAAVQK MVENLKKQIS ELKIKNQQLD LENTELSQKN SQNQEKLQEL NQRLTEMLCQ 1620 KEKEPGNSAL EEREQEKFNL KEELERCKVQ SSTLVSSLEA ELSEVKIQTH IVQQENHLLK 1680 DELEKMKQLH RCPDLSDFQQ KISSVLSYNE KLLKEKEALS EELNSCVDKL AKSSLLEHRI 1740 ATMKQEQKSW EHQSASLKSQ LVASQEKVQN LEDTVQNVNL QMSRMKSDLR VTQQEKEALK 1800 QEVMSLHKQL QNAGGKSWAP EIATHPSGLH NQQKRLSWDK LDHLMNEEQQ LLWQENERLQ 1860 TMVQNTKAEL THSREKVRQL ESNLLPKHQK HLNPSGTMNP TEQEKLSLKR ECDQFQKEQS 1920 PANRKVSQMN SLEQELETIH LENEGLKKKQ VKLDEQLMEM QHLRSTATPS PSPHAWDLQL 1980 LQQQACPMVP REQFLQLQRQ LLQAERINQH LQEELENRTS ETNTPQGNQE QLVTVMEERM 2040 IEVEQKLKLV KRLLQEKVNQ LKEQVSLPGH LCSPTSHSSF NSSFTSLYCH 2091 |
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Database | Annotation |
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Cancer Gene Census | MPN |
GWASdb (count: 21) (view all) | rs4534750; Cognitive test performance; cognitive disorder
rs1599969; Cholesterol; arteriosclerosis|coronary artery disease|lipid metabolism disorder rs2984272; Asthma; asthma rs2984274; Brain lesion load; multiple sclerosis rs10148309; Smoking initiation; nicotine dependence rs11624766; Lupus nephritis in systemic lupus erythematosus; systemic lupus erythematosus |
PTM | Modification Sites |
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Phosphorylation (count: 44) (view all) | 1009 DRERAEMSTEISRLQ dbPAF
1010 RERAEMSTEISRLQS dbPAF 1013 AEMSTEISRLQSKIK dbPAF 1017 TEISRLQSKIKEMQQ dbPAF 1145 VTRRHVLSDLEDDEV dbPAF 1157 DEVRDLGSTGTSSVQ dbPAF |
Ubiquitination (count: 5) | 1477 ERVTILVKQKDVLSH PLMD
1641 EQEKFNLKEELERCK PLMD 434 KERIAALKNELRKER PLMD 478 DRLALSLKENSRLEN PLMD 97 CSLEAQPKYVRGGKR PLMD |
Sumoylation (count: 3) | 1641 EQEKFNLKEELERCK PLMD
1680 QQENHLLKDELEKMK PLMD 707 EKKQLQVKLEEEKTH PLMD |
Glycation (count: 1) | 1169 SVQRQEVKIEESEAS PLMD |
Network | Interaction | ||
---|---|---|---|
A | B | Source | |