| Tag | Content |
|---|---|
| UniProt Accession | RHG24_HUMAN; Q8N264; |
| Entrez ID | 83478 |
| GenBank Protein ID | NM_001025616.2; NM_001042669.1; NM_031305.2; XM_011532300.2; |
| GenBank Nucleotide ID | NP_001020787.2; NP_001036134.1; NP_112595.2; XP_011530602.1; |
| Protein Name | Rho GTPase-activating protein 24 (Filamin-A-associated RhoGAP) (FilGAP) (RAC1- and CDC42-specific GTPase-activating protein of 72 kDa) (RC-GAP72) (Rho-type GTPase-activating protein 24) (RhoGAP of 73 kDa) (Sarcoma antigen NY-SAR-88) (p73RhoGAP) |
| Gene Name | ARHGAP24; FILGAP |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis. |
| Sequence (Fasta) | MEENNDSTEN PQQGQGRQNA IKCGWLRKQG GFVKTWHTRW FVLKGDQLYY FKDEDETKPL 60 GTIFLPGNKV SEHPCNEENP GKFLFEVVPG GDRDRMTANH ESYLLMASTQ NDMEDWVKSI 120 RRVIWGPFGG GIFGQKLEDT VRYEKRYGNR LAPMLVEQCV DFIRQRGLKE EGLFRLPGQA 180 NLVKELQDAF DCGEKPSFDS NTDVHTVASL LKLYLRELPE PVIPYAKYED FLSCAKLLSK 240 EEEAGVKELA KQVKSLPVVN YNLLKYICRF LDEVQSYSGV NKMSVQNLAT VFGPNILRPK 300 VEDPLTIMEG TVVVQQLMSV MISKHDCLFP KDAELQSKPQ DGVSNNNEIQ KKATMGQLQN 360 KENNNTKDSP SRQCSWDKSE SPQRSSMNNG SPTALSGSKT NSPKNSVHKL DVSRSPPLMV 420 KKNPAFNKGS GIVTNGSFSS SNAEGLEKTQ TTPNGSLQAR RSSSLKVSGT KMGTHSVQNG 480 TVRMGILNSD TLGNPTNVRN MSWLPNGYVT LRDNKQKEQA GELGQHNRLS TYDNVHQQFS 540 MMNLDDKQSI DSATWSTSSC EISLPENSNS CRSSTTTCPE QDFFGGNFED PVLDGPPQDD 600 LSHPRDYESK SDHRSVGGRS SRATSSSDNS ETFVGNSSSN HSALHSLVSS LKQEMTKQKI 660 EYESRIKSLE QRNLTLETEM MSLHDELDQE RKKFTMIEIK MRNAERAKED AEKRNDMLQK 720 EMEQFFSTFG ELTVEPRRTE RGNTIWIQ 749 |
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| Database | Annotation |
|---|---|
| GWASdb (count: 53) (view all) | rs10015995; Non-small cell lung cancer; non-small cell lung carcinoma
rs1481779; Stroke; cerebrovascular disease rs4693701; Schizophrenia; schizophrenia rs1994074; Alcohol dependence; alcohol dependence rs9307004; Varicose Veins; Null rs7698203; Vaspin levels; obesity|type 2 diabetes mellitus |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 25) (view all) | 354 NEIQKKATMGQLQNK dbPAF
369 ENNNTKDSPSRQCSW dbPAF 371 NNTKDSPSRQCSWDK dbPAF 381 CSWDKSESPQRSSMN dbPAF 391 RSSMNNGSPTALSGS dbPAF 393 SMNNGSPTALSGSKT dbPAF |
| Network | Interaction | ||
|---|---|---|---|
| A | B | Source | |