Q8N0W4

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession NLGNX_HUMAN; Q8N0W4;
Entrez ID 57502
GenBank Protein ID NM_001282145.1; NM_001282146.1; NM_020742.3; NM_181332.2; XM_005274564.2; XM_005274565.2; XM_005274566.4; XM_006724504.3; XM_011545547.2; XM_011545548.2; XM_017029690.1; XM_017029691.1; XM_017029692.1; XM_017029693.1;
GenBank Nucleotide ID NP_001269074.1; NP_001269075.1; NP_065793.1; NP_851849.1; XP_005274621.1; XP_005274622.1; XP_005274623.1; XP_006724567.1; XP_011543849.1; XP_011543850.1; XP_016885179.1; XP_016885180.1; XP_016885181.1; XP_016885182.1;
Protein Name Neuroligin-4, X-linked (Neuroligin X) (HNLX)
Gene Name NLGN4X; KIAA1260; NLGN4; UNQ365/PRO701
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionPutative neuronal cell surface protein involved in cell-cell-interactions.
Sequence
(Fasta)		MSRPQGLLWL PLLFTPVCVM LNSNVLLWLT ALAIKFTLID SQAQYPVVNT NYGKIRGLRT 60
PLPNEILGPV EQYLGVPYAS PPTGERRFQP PEPPSSWTGI RNTTQFAAVC PQHLDERSLL 120
HDMLPIWFTA NLDTLMTYVQ DQNEDCLYLN IYVPTEDDIH DQNSKKPVMV YIHGGSYMEG 180
TGNMIDGSIL ASYGNVIVIT INYRLGILGF LSTGDQAAKG NYGLLDQIQA LRWIEENVGA 240
FGGDPKRVTI FGSGAGASCV SLLTLSHYSE GLFQKAIIQS GTALSSWAVN YQPAKYTRIL 300
ADKVGCNMLD TTDMVECLRN KNYKELIQQT ITPATYHIAF GPVIDGDVIP DDPQILMEQG 360
EFLNYDIMLG VNQGEGLKFV DGIVDNEDGV TPNDFDFSVS NFVDNLYGYP EGKDTLRETI 420
KFMYTDWADK ENPETRRKTL VALFTDHQWV APAVATADLH AQYGSPTYFY AFYHHCQSEM 480
KPSWADSAHG DEVPYVFGIP MIGPTELFSC NFSKNDVMLS AVVMTYWTNF AKTGDPNQPV 540
PQDTKFIHTK PNRFEEVAWS KYNPKDQLYL HIGLKPRVRD HYRATKVAFW LELVPHLHNL 600
NEIFQYVSTT TKVPPPDMTS FPYGTRRSPA KIWPTTKRPA ITPANNPKHS KDPHKTGPED 660
TTVLIETKRD YSTELSVTIA VGASLLFLNI LAFAALYYKK DKRRHETHRR PSPQRNTTND 720
IAHIQNEEIM SLQMKQLEHD HECESLQAHD TLRLTCPPDY TLTLRRSPDD IPLMTPNTIT 780
MIPNTLTGMQ PLHTFNTFSG GQNSTNLPHG HSTTRV 817

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Threonine PhosphorylationAsd autism spectrumDT70725675530
[Reference]: Endogenous NLGN4X is intensely phosphorylated on T707 upon PKC stimulation in human neurons. Furthermore, a phospho-mimetic mutation at T707 has a profound effect on NLGN4X-mediated excitatory potentiation.

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 3)		OMIM:300497 ; ASPERGER SYNDROME, X-LINKED, SUSCEPTIBILITY TO, 2
MESH:D000067877 ; Autism Spectrum Disorder
MESH:D001321 ; Autistic Disorder
GWASdb
(count: 11)
(view all)		rs17305859; Urinary metabolites; kidney disease
rs6639583; Schizophrenia; schizophrenia
rs6639583; Psychosis; psychotic disorder
rs1882411; Schizophrenia; schizophrenia
rs1882411; F-cell distribution; sickle cell anemia
rs1882411; Major depression (suicidal thoughts and behavior); major depressive disorder

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 7)
(view all)		 407       SNFVDNLYGYPEGKD     dbPAF
409       FVDNLYGYPEGKDTL     dbPAF
671       LIETKRDYSTELSVT     dbPAF
698       LAFAALYYKKDKRRH     dbPAF
707       KDKRRHETHRRPSPQ     dbPAF
760       RLTCPPDYTLTLRRS     dbPAF