Tag | Content |
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UniProt Accession | PELP1_HUMAN; Q8IZL8; |
Entrez ID | 27043 |
GenBank Protein ID | NM_001278241.1; NM_014389.2; |
GenBank Nucleotide ID | NP_001265170.1; NP_055204.3; |
Protein Name | Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of non-genomic activity of estrogen receptor) (Transcription factor HMX3) |
Gene Name | PELP1; HMX3; MNAR |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence-specific transcription factors. Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycle progression by interacting with RB1. May have important functional implications in ER/growth facto(view all) |
Sequence (Fasta) | MAAAVLSGPS AGSAAGVPGG TGGLSAVSSG PRLRLLLLES VSGLLQPRTG SAVAPVHPPN 60 RSAPHLPGLM CLLRLHGSVG GAQNLSALGA LVSLSNARLS SIKTRFEGLC LLSLLVGESP 120 TELFQQHCVS WLRSIQQVLQ TQDPPATMEL AVAVLRDLLR YAAQLPALFR DISMNHLPGL 180 LTSLLGLRPE CEQSALEGMK ACMTYFPRAC GSLKGKLASF FLSRVDALSP QLQQLACECY 240 SRLPSLGAGF SQGLKHTESW EQELHSLLAS LHTLLGALYE GAETAPVQNE GPGVEMLLSS 300 EDGDAHVLLQ LRQRFSGLAR CLGLMLSSEF GAPVSVPVQE ILDFICRTLS VSSKNISLHG 360 DGPLRLLLLP SIHLEALDLL SALILACGSR LLRFGILIGR LLPQVLNSWS IGRDSLSPGQ 420 ERPYSTVRTK VYAILELWVQ VCGASAGMLQ GGASGEALLT HLLSDISPPA DALKLRSPRG 480 SPDGSLQTGK PSAPKKLKLD VGEAMAPPSH RKGDSNANSD VCAAALRGLS RTILMCGPLI 540 KEETHRRLHD LVLPLVMGVQ QGEVLGSSPY TSSRCRRELY CLLLALLLAP SPRCPPPLAC 600 ALQAFSLGQR EDSLEVSSFC SEALVTCAAL THPRVPPLQP MGPTCPTPAP VPPPEAPSPF 660 RAPPFHPPGP MPSVGSMPSA GPMPSAGPMP SAGPVPSARP GPPTTANHLG LSVPGLVSVP 720 PRLLPGPENH RAGSNEDPIL APSGTPPPTI PPDETFGGRV PRPAFVHYDK EEASDVEISL 780 ESDSDDSVVI VPEGLPPLPP PPPSGATPPP IAPTGPPTAS PPVPAKEEPE ELPAAPGPLP 840 PPPPPPPPVP GPVTLPPPQL VPEGTPGGGG PPALEEDLTV ININSSDEEE EEEEEEEEEE 900 EEEEEEEEDF EEEEEDEEEY FEEEEEEEEE FEEEFEEEEG ELEEEEEEED EEEEEELEEV 960 EDLEFGTAGG EVEEGAPPPP TLPPALPPPE SPPKVQPEPE PEPGLLLEVE EPGTEEERGA 1020 DTAPTLAPEA LPSQGEVERE GESPAAGPPP QELVEEEPSA PPTLLEEETE DGSDKVQPPP 1080 ETPAEEEMET ETEAEALQEK EQDDTAAMLA DFIDCPPDDE KPPPPTEPDS 1131 |
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Database | Annotation |
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GWASdb (count: 12) (view all) | rs8071990; Prostate cancer; prostate cancer
rs7221588; Multiple complex diseases; Null rs7214568; Multiple complex diseases; Null rs9899501; Multiple complex diseases; Null rs906453; Alcohol dependence; alcohol dependence rs906453; Alcoholism; alcohol dependence |
PTM | Modification Sites |
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Phosphorylation (count: 31) (view all) | 101 LSNARLSSIKTRFEG dbPAF
1014 LEVEEPGTEEERGAD dbPAF 1022 EEERGADTAPTLAPE dbPAF 1033 LAPEALPSQGEVERE dbPAF 104 ARLSSIKTRFEGLCL dbPAF 1043 EVEREGESPAAGPPP dbPAF |
Acetylation (count: 4) | 216 ACGSLKGKLASFFLS PLMD
354 RTLSVSSKNISLHGD PLMD 490 DGSLQTGKPSAPKKL PLMD 495 TGKPSAPKKLKLDVG PLMD |
Ubiquitination (count: 6) | 103 NARLSSIKTRFEGLC PLMD
216 ACGSLKGKLASFFLS PLMD 354 RTLSVSSKNISLHGD PLMD 496 GKPSAPKKLKLDVGE PLMD 512 MAPPSHRKGDSNANS PLMD 541 LMCGPLIKEETHRRL PLMD |
Sumoylation (count: 1) | 826 ASPPVPAKEEPEELP PLMD |
Malonylation (count: 1) | 354 RTLSVSSKNISLHGD PLMD |
Network | Interaction | ||
---|---|---|---|
A | B | Source | |