Q8IZL8

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession PELP1_HUMAN; Q8IZL8;
Entrez ID 27043
GenBank Protein ID NM_001278241.1; NM_014389.2;
GenBank Nucleotide ID NP_001265170.1; NP_055204.3;
Protein Name Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of non-genomic activity of estrogen receptor) (Transcription factor HMX3)
Gene Name PELP1; HMX3; MNAR
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionCoactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence-specific transcription factors. Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycle progression by interacting with RB1. May have important functional implications in ER/growth facto(view all)
Sequence
(Fasta)
MAAAVLSGPS AGSAAGVPGG TGGLSAVSSG PRLRLLLLES VSGLLQPRTG SAVAPVHPPN 60
RSAPHLPGLM CLLRLHGSVG GAQNLSALGA LVSLSNARLS SIKTRFEGLC LLSLLVGESP 120
TELFQQHCVS WLRSIQQVLQ TQDPPATMEL AVAVLRDLLR YAAQLPALFR DISMNHLPGL 180
LTSLLGLRPE CEQSALEGMK ACMTYFPRAC GSLKGKLASF FLSRVDALSP QLQQLACECY 240
SRLPSLGAGF SQGLKHTESW EQELHSLLAS LHTLLGALYE GAETAPVQNE GPGVEMLLSS 300
EDGDAHVLLQ LRQRFSGLAR CLGLMLSSEF GAPVSVPVQE ILDFICRTLS VSSKNISLHG 360
DGPLRLLLLP SIHLEALDLL SALILACGSR LLRFGILIGR LLPQVLNSWS IGRDSLSPGQ 420
ERPYSTVRTK VYAILELWVQ VCGASAGMLQ GGASGEALLT HLLSDISPPA DALKLRSPRG 480
SPDGSLQTGK PSAPKKLKLD VGEAMAPPSH RKGDSNANSD VCAAALRGLS RTILMCGPLI 540
KEETHRRLHD LVLPLVMGVQ QGEVLGSSPY TSSRCRRELY CLLLALLLAP SPRCPPPLAC 600
ALQAFSLGQR EDSLEVSSFC SEALVTCAAL THPRVPPLQP MGPTCPTPAP VPPPEAPSPF 660
RAPPFHPPGP MPSVGSMPSA GPMPSAGPMP SAGPVPSARP GPPTTANHLG LSVPGLVSVP 720
PRLLPGPENH RAGSNEDPIL APSGTPPPTI PPDETFGGRV PRPAFVHYDK EEASDVEISL 780
ESDSDDSVVI VPEGLPPLPP PPPSGATPPP IAPTGPPTAS PPVPAKEEPE ELPAAPGPLP 840
PPPPPPPPVP GPVTLPPPQL VPEGTPGGGG PPALEEDLTV ININSSDEEE EEEEEEEEEE 900
EEEEEEEEDF EEEEEDEEEY FEEEEEEEEE FEEEFEEEEG ELEEEEEEED EEEEEELEEV 960
EDLEFGTAGG EVEEGAPPPP TLPPALPPPE SPPKVQPEPE PEPGLLLEVE EPGTEEERGA 1020
DTAPTLAPEA LPSQGEVERE GESPAAGPPP QELVEEEPSA PPTLLEEETE DGSDKVQPPP 1080
ETPAEEEMET ETEAEALQEK EQDDTAAMLA DFIDCPPDDE KPPPPTEPDS 1131

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Serine PhosphorylationBreast cancer/tumor/carcinomaUS103325788226
[Reference]: Further, PELP1 regulates E2F1 stability in a KDM1A-dependent manner, and PELP1 phosphorylation at the S1033 residue plays an important role in mediating its oncogenic functions in TNBC cells.?

※ Disease Cross-ref Annotation

DatabaseAnnotation
GWASdb
(count: 12)
(view all)
rs8071990; Prostate cancer; prostate cancer
rs7221588; Multiple complex diseases; Null
rs7214568; Multiple complex diseases; Null
rs9899501; Multiple complex diseases; Null
rs906453; Alcohol dependence; alcohol dependence
rs906453; Alcoholism; alcohol dependence

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 31)
(view all)
101       LSNARLSSIKTRFEG     dbPAF
1014      LEVEEPGTEEERGAD     dbPAF
1022      EEERGADTAPTLAPE     dbPAF
1033      LAPEALPSQGEVERE     dbPAF
104       ARLSSIKTRFEGLCL     dbPAF
1043      EVEREGESPAAGPPP     dbPAF
Acetylation
(count: 4)
216       ACGSLKGKLASFFLS     PLMD
354       RTLSVSSKNISLHGD     PLMD
490       DGSLQTGKPSAPKKL     PLMD
495       TGKPSAPKKLKLDVG     PLMD
Ubiquitination
(count: 6)
103       NARLSSIKTRFEGLC     PLMD
216       ACGSLKGKLASFFLS     PLMD
354       RTLSVSSKNISLHGD     PLMD
496       GKPSAPKKLKLDVGE     PLMD
512       MAPPSHRKGDSNANS     PLMD
541       LMCGPLIKEETHRRL     PLMD
Sumoylation
(count: 1)
826       ASPPVPAKEEPEELP     PLMD
Malonylation
(count: 1)
354       RTLSVSSKNISLHGD     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource