Q8IUI8

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession CRLF3_HUMAN; Q8IUI8;
Entrez ID 51379
GenBank Protein ID
GenBank Nucleotide ID
Protein Name Cytokine receptor-like factor 3 (Cytokine receptor-like molecule 9) (CREME-9) (Cytokine receptor-related protein 4) (Type I cytokine receptor-like factor p48)
Gene Name CRLF3; CREME9; CRLM9; CYTOR4; P48
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionMay play a role in the negative regulation of cell cycle progression.
Sequence
(Fasta)		MRGAMELEPE LLLQEARENV EAAQSYRREL GHRLEGLREA RRQIKESASQ TRDVLKQHFN 60
DLKGTLGKLL DERLVTLLQE VDTIEQETIK PLDDCQKLIE HGVNTAEDLV REGEIAMLGG 120
VGEENEKLWS FTKKASHIQL DSLPEVPLLV DVPCLSAQLD DSILNIVKDH IFKHGTVASR 180
PPVQIEELIE KPGGIIVRWC KVDDDFTAQD YRLQFRKCTS NHFEDVYVGS ETEFIVLHID 240
PNVDYQFRVC ARGDGRQEWS PWSVPQIGHS TLVPHEWTAG FEGYSLSSRR NIALRNDSES 300
SGVLYSRAPT YFCGQTLTFR VETVGQPDRR DSIGVCAEKQ DGYDSLQRDQ AVCISTNGAV 360
FVNGKEMTNQ LPAVTSGSTV TFDIEAVTLG TTSNNEGGHF KLRVTISSNN REVVFDWLLD 420
QSCGSLYFGC SFFYPGWKVL VF 443

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1UbiquitinationCancer cachexia/Cachexia/Cachectic tumorA24280222
[Reference]: Phosphorylation and ubiquitylation regulate the GH receptor (GHR) at the cell surface: two ubiquitin ligases (SCF(TrCP2) and CHIP) determine the GH responsiveness of cells by controlling its endocytosis, whereas JAK2 initiates the JAK/STAT pathway. We used blue native electrophoresis to identify phosphorylated and ubiquitylated receptor intermediates

※ Disease Cross-ref Annotation

DatabaseAnnotation
GWASdb
(count: 1)		rs1061342; Information processing speed; cognitive disorder

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 2)		 162       LSAQLDDSILNIVKD     dbPAF
332       GQPDRRDSIGVCAEK     dbPAF
Acetylation
(count: 1)		 68        DLKGTLGKLLDERLV     PLMD
Ubiquitination
(count: 5)		 191       QIEELIEKPGGIIVR     PLMD
339       SIGVCAEKQDGYDSL     PLMD
45        REARRQIKESASQTR     PLMD
56        SQTRDVLKQHFNDLK     PLMD
68        DLKGTLGKLLDERLV     PLMD