Tag | Content |
---|---|
UniProt Accession | ANM5_MOUSE; Q8CIG8; |
Entrez ID | 27374 |
GenBank Protein ID | NM_001313906.1; NM_001313907.1; NM_013768.3; |
GenBank Nucleotide ID | NP_001300835.1; NP_001300836.1; NP_038796.2; |
Protein Name | Protein arginine N-methyltransferase 5 (EC 2.1.1.320) (Histone-arginine N-methyltransferase PRMT5) (Jak-binding protein 1) (Shk1 kinase-binding protein 1 homolog) (SKB1 homolog) |
Gene Name | Prmt5; Jbp1; Skb1 |
Organism | Mus musculus |
NCBI Taxa ID | 10090 |
Functional Description | Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA (PubMed:15485929, PubMed:19584108, PubMed:19858291, PubMed:21917714, PubMed:23133559). Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Methylates SUPT5H and may regulate its tra(view all) |
Sequence (Fasta) | MAAMAVGGAG GSRVSSGRDL NCVPEIADTL GAVAKQGFDF LCMPVFHPRF KREFIQEPAK 60 NRPGPQTRSD LLLSGRDWNT LIVGKLSPWI HPDSKVEKIR RNSEAAMLQE LNFGAYLGLP 120 AFLLPLNQED NTNLARVLTN HIHTGHHSSM FWMRVPLVAP EDLRDDVIAN APTTHTEEYS 180 GEEKTWMWWH NFRTLCDYSK RIAVALEIGA DLPSNHVIDR WLGEPIKAAI LPTSIFLTNK 240 KGFPVLSKVQ QRLIFRLLKL EVQFIITGTN HHSEKEFCSY LQYLEYLSQN RPPPNAYELF 300 AKGYEDYLQS PLQPLMDNLE SQTYEVFEKD PIKYSQYQQA IYKCLLDRVP EEEKETNVQV 360 LMVLGAGRGP LVNASLRAAK QAERRIRLYA VEKNPNAVVT LENWQFEEWG SQVTVVSSDM 420 REWVAPEKAD IIVSELLGSF ADNELSPECL DGAQHFLKDD GVSIPGEYTS FLAPISSSKL 480 YNEVRACREK DRDPEAQFEM PYVVRLHNFH QLSAPKPCFT FSHPNRDPMI DNNRYCTLEF 540 PVEVNTVLHG FAGYFETVLY RDITLSIRPE THSPGMFSWF PIFFPIKQPI TVHEGQNICV 600 RFWRCSNSKK VWYEWAVTAP VCSSIHNPTG RSYTIGL 638 |
|
PTM | Modification Sites |
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Phosphorylation (count: 1) | 310 GYEDYLQSPLQPLMD dbPAF |
Ubiquitination (count: 3) | 227 RWLGEPIKAAILPTS PLMD
240 TSIFLTNKKGFPVLS PLMD 95 PWIHPDSKVEKIRRN PLMD |
Network | Interaction | ||
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A | B | Source | |