Q8CHW4

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession EI2BE_MOUSE; Q8CHW4;
Entrez ID 224045
GenBank Protein ID
GenBank Nucleotide ID
Protein Name Translation initiation factor eIF-2B subunit epsilon (eIF-2B GDP-GTP exchange factor subunit epsilon)
Gene Name Eif2b5
Organism Mus musculus
NCBI Taxa ID 10090
Functional DescriptionCatalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.
Sequence
(Fasta)
MAATAAVPGA AAGRASKRGG GGSGGGGTQG AEEEPPPPLQ AVLVADSFNR RFFPISKDQP 60
RVLLPLANVA LIDYTLEFLT ATGVQETFVF CCWKAAQIKE HLQKSKWCHP TSPNVVRIIT 120
SELYRSLGDV LRDVDAKALV RSDFLLIYGD VISNINICRA LEEHRLRRKL EKNVSVMTMV 180
FKESSPSHPT RCHEDNVVMA VDSATNRVLH FQKTQGLRRF SFPLSLFQGS GDGVEIRYDL 240
LDCHISICSP QVAQLFTDNF DYQTRDDFVR GILMNEEVLG NQIHLHVTTR EYGARVSNLH 300
MYSAVCADVI RRWVYPLTPE VNFTDSTTQS YTHSRHNIYR GPEVSLGHGS VLEENVLLGA 360
GTVIGSNCSI TNSVIGPNCH IGDNVVLDQA YLWQGVRVAA GAQIHQSLLC DRAEVKERVK 420
LKPYCVLTSQ VVVGPDITLP EGSVISLHPP DAEEDEDDGQ FSDDSGADQE KEKVKLKGYN 480
PAEVGLEGQG YLWKAEGVNS KEDEELRQSL WGLMIKTEEE SETESEGSVD PEELDSRAGS 540
PQLDDIRVFQ NEVLGTLQRG REENISCENL VLEINSLKHA YNISLKEVMQ VLTLVVLEFP 600
LQQVDGLLDP NRYCALLLPL LKAWSPVLRN YIKRAADHLE ALAAIEDFFL EHETLVTSMA 660
KVLMAFYQLE ILAEETILSW FSQRDTTDEG QQLRKNQQLQ RFIQWLREAE EESSEDD 718

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Serine PhosphorylationDiabetes mellitusDS54018701453
[Reference]: GSK3beta and eIF2Bepsilon play a role in augmented protein synthesis associated with high glucose- and high insulin-stimulated hypertrophy and matrix accumulation in renal disease in type 2 diabetes

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 2)
MESH:C538231 ; Adenocarcinoma of lung
MESH:C565836 ; Vanishing White Matter Leukodystrophy with Ovarian Failure

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 17)
(view all)
16        GAAAGRASKRGGGGS     dbPAF
221       TQGLRRFSFPLSLFQ     dbPAF
225       RRFSFPLSLFQGSGD     dbPAF
23        SKRGGGGSGGGGTQG     dbPAF
28        GGSGGGGTQGAEEEP     dbPAF
4         ****MAATAAVPGAA     dbPAF
Ubiquitination
(count: 1)
477       EKEKVKLKGYNPAEV     PLMD