| Tag | Content |
|---|---|
| UniProt Accession | TBCD4_MOUSE; Q8BYJ6; |
| Entrez ID | 210789 |
| GenBank Protein ID | NM_001081278.2; XM_006518759.3; XM_011245002.2; |
| GenBank Nucleotide ID | NP_001074747.2; XP_006518822.1; XP_011243304.1; |
| Protein Name | TBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160) |
| Gene Name | Tbc1d4; As160; Kiaa0603 |
| Organism | Mus musculus |
| NCBI Taxa ID | 10090 |
| Functional Description | May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake (By similarity). |
| Sequence (Fasta) | MESPSCIQDE PFPHPLEPEP SAPAQPGATK PGDKRFRLWY VGGSCLDRRT TLPMLPWLMA 60 EIRRRSQKPD AGGCGAPAAR EVILVLSAPF LRCVPAPGAG VGGGAGSGAV QPNTGVFIFE 120 HKAQHISRFI HNSHDLTYFA YLIKAQPDDP ESQMACHVFR ATDPNQVPDV ISSIRQLSKA 180 AMKEDSKPSK DNEDAFYNSQ KFEVLYCGRV IVTHKKAPSS LIDDCKDKFS LHEQQRLKLQ 240 GERGGDPGDE MGVLEVESPV SPDDSLPEKA DGTVNSPRAL PSLASLPALA SQPALASSRV 300 CFPERILEDC GFDEQQEFRS RCSSVTGVMQ KKVHENNQKT QPRRRHASAP SHVQPSDSEK 360 NRTMLFQVGR FEINLISPDT KSVVLEKNFK DISSCSQGIK HVDHFGFICR ESPEPGLSQY 420 ICYVFQCANE SLVDEVMLTL KQAFSTAAAL QSAKTQIKLC ETCPMHSLHK LCERIEGLYP 480 PRAKLVIQRH LSSLTDNEQA DIFERVQKMK PISDQEENEL VILHLRQLCE AKQRTHVHIG 540 EGPAIISNST IPENVTSGGR FKLDVLKNKA KRSLTSSLEN IFSRGANRMR GRLGSMDSFE 600 RANSLASEKD FSPGDSPPGT PPASPLSSAW HAFPEEDSDS PQFRRRAHTF SHPPSSSRRK 660 LNLQDGKAHG LRSPLLRQSS SEQCSIVPSA RRMYKESNSS CSLPSLHTSF SAPSFTAPSF 720 LKSFYQNSGR LSPQYENEIR QDTASESSDG EGRKRTSSTC SNESLNAGGT PVTPRRVSWR 780 QRIFLRVASP VNKSPSAMQQ QKDGLDRTEL LPLSPLSPTM EEEPLIIFLS GDEDTEKVEE 840 KKKSKELKSL WKKAIHQQIL LLRMEKENQK LEEARRDELQ SRKVKLDYEE VGTCQKEILI 900 AWDKKLLNCR TKIRCDMEDI HTSLKEGVPK SRRGEIWQFL ALQYRLRHRL PNKHQPPDTS 960 YKELLKQLTA QQHAILVDLG RTFPTHPYFS VQLGAGQLSL FNLLKAYSLL DKEVGYCQGI 1020 SFVAGVLLLH MSEEQAFEML KFLMYDLGFR KQYRPDMMSL QIQMYQLSRL LHDYHRELYN 1080 HLEENEISPS LYAAPWFLTL FASQFPLGFV ARVFDIIFLQ GTEVIFKVAL SLLSSQEALI 1140 MECENFENIV EFLKSTLPDM NTTEMEKIIT QVFEMDISKQ LHAYEVEYHV LQDELLESSY 1200 ACEDNESLEK LERANNQLKR QNMDLLEKLQ VAHAKIQALE SNLETLLTRE TKMKALIRTL 1260 EQDKMAYQKT VEQIRKLLPA DALANCELLL KDLTHPTNDK AKAGNKP 1308 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 1) | OMIM:616087 ; DIABETES MELLITUS, NONINSULIN-DEPENDENT, 5 |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 46) (view all) | 1135 VALSLLSSQEALIME dbPAF
230 DDCKDKFSLHEQQRL dbPAF 258 MGVLEVESPVSPDDS dbPAF 261 LEVESPVSPDDSLPE dbPAF 276 KADGTVNSPRALPSL dbPAF 3 *****MESPSCIQDE dbPAF |
| Acetylation (count: 1) | 484 GLYPPRAKLVIQRHL PLMD |