| Tag | Content |
|---|---|
| UniProt Accession | SMAD3_MOUSE; Q8BUN5; |
| Entrez ID | 17127 |
| GenBank Protein ID | |
| GenBank Nucleotide ID | |
| Protein Name | Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (mMad3) (SMAD family member 3) (SMAD 3) (Smad3) |
| Gene Name | Smad3; Madh3 |
| Organism | Mus musculus |
| NCBI Taxa ID | 10090 |
| Functional Description | Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity). |
| Sequence (Fasta) | MSSILPFTPP IVKRLLGWKK GEQNGQEEKW CEKAVKSLVK KLKKTGQLDE LEKAITTQNV 60 NTKCITIPRS LDGRLQVSHR KGLPHVIYCR LWRWPDLHSH HELRAMELCE FAFNMKKDEV 120 CVNPYHYQRV ETPVLPPVLV PRHTEIPAEF PPLDDYSHSI PENTNFPAGI EPQSNIPETP 180 PPGYLSEDGE TSDHQMNHSM DAGSPNLSPN PMSPAHNNLD LQPVTYCEPA FWCSISYYEL 240 NQRVGETFHA SQPSMTVDGF TDPSNSERFC LGLLSNVNRN AAVELTRRHI GRGVRLYYIG 300 GEVFAECLSD SAIFVQSPNC NQRYGWHPAT VCKIPPGCNL KIFNNQEFAA LLAQSVNQGF 360 EAVYQLTRMC TIRMSFVKGW GAEYRRQTVT STPCWIELHL NGPLQWLDKV LTQMGSPSIR 420 CSSVS 426 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 12) (view all) | MESH:D000784
; Aneurysm, Dissecting MESH:D001014 ; Aortic Aneurysm MESH:D001171 ; Arthritis, Juvenile MESH:D019465 ; Craniofacial Abnormalities MESH:D003424 ; Crohn Disease MESH:D007889 ; Leiomyoma |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 9) (view all) | 132 YHYQRVETPVLPPVL dbPAF
2 ******MSSILPFTP dbPAF 309 EVFAECLSDSAIFVQ dbPAF 388 GAEYRRQTVTSTPCW dbPAF 416 KVLTQMGSPSIRCSS dbPAF 422 GSPSIRCSSVS**** dbPAF |