| Tag | Content |
|---|---|
| UniProt Accession | PDK1_MOUSE; Q8BFP9; |
| Entrez ID | 228026 |
| GenBank Protein ID | |
| GenBank Nucleotide ID | |
| Protein Name | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 1) (PDH kinase 1) |
| Gene Name | Pdk1 |
| Organism | Mus musculus |
| NCBI Taxa ID | 10090 |
| Functional Description | Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress (By similarity). |
| Sequence (Fasta) | MRLARLLRGG TSVRPLCAVP CASRSLASAS ASGSGPASEL GVPGQVDFYA RFSPSPLSMK 60 QFLDFGSVNA CEKTSFMFLR QELPVRLANI MKEISLLPDN LLRTPSVQLV QSWYIQSLQE 120 LLDFKDKSAE DAKTIYEFTD TVIRIRNRHN DVIPTMAQGV TEYKESFGVD PVTSQNVQYF 180 LDRFYMSRIS IRMLLNQHSL LFGGKGSPSH RKHIGSINPN CDVVEVIKDG YENARRLCDL 240 YYVNSPELEL EELNAKSPGQ TIQVVYVPSH LYHMVFELFK NAMRATMEHH ADKGVYPPIQ 300 VHVTLGEEDL TVKMSDRGGG VPLRKIDRLF NYMYSTAPRP RVETSRAVPL AGFGYGLPIS 360 RLYAQYFQGD LKLYSLEGYG TDAVIYIKAL STESVERLPV YNKAAWKHYK ANHEADDWCV 420 PSREPKDMTT FRSS 435 |
|
|||||||||||||||||||||||||||||||||
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 6) | 136 AEDAKTIYEFTDTVI dbPAF
241 ARRLCDLYYVNSPEL dbPAF 242 RRLCDLYYVNSPELE dbPAF 344 APRPRVETSRAVPLA dbPAF 345 PRPRVETSRAVPLAG dbPAF 433 KDMTTFRSS****** dbPAF |
| Acetylation (count: 1) | 403 ERLPVYNKAAWKHYK PLMD |
| Succinylation (count: 1) | 403 ERLPVYNKAAWKHYK PLMD |
| Network | Interaction | ||
|---|---|---|---|
| A | B | Source | |