Tag | Content |
---|---|
UniProt Accession | FACD2_MOUSE; Q80V62; |
Entrez ID | 211651 |
GenBank Protein ID | |
GenBank Nucleotide ID | |
Protein Name | Fanconi anemia group D2 protein homolog (Protein FACD2) |
Gene Name | Fancd2 |
Organism | Mus musculus |
NCBI Taxa ID | 10090 |
Functional Description | Required for maintenance of chromosomal stability. Promotes accurate and efficient pairing of homologs during meiosis. Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing. May participate in S phase and G2 phase checkpoint activation upon DNA damage. Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress (By similarity). Promotes BRCA2/FANCD1 loading onto damaged chromatin. May also be involved in B-cell immunoglobulin isotype switching. |
Sequence (Fasta) | MISKRRRLDS EDKENLTEDA SKTMPLSKLA KKSHNSHEVE ENGSVFVKLL KASGLTLKTG 60 ENQNQLGVDQ VIFQRKLFQA LRKHPAYPKV IEEFVNGLES YTEDSESLRN CLLSCERLQD 120 EEASMGTFYS KSLIKLLLGI DILQPAIIKM LFEKVPQFLF ESENRDGINM ARLIINQLKW 180 LDRIVDGKDL TAQMMQLISV APVNLQHDFI TSLPEILGDS QHANVGKELG ELLVQNTSLT 240 VPILDVFSSL RLDPNFLSKI RQLVMGKLSS VRLEDFPVIV KFLLHSVTDT TSLEVIAELR 300 ENLNVQQFIL PSRIQASQSK LKSKGLASSS GNQENSDKDC IVLVFDVIKS AIRYEKTISE 360 AWFKAIERIE SAAEHKALDV VMLLIIYSTS TQTKKGVEKL LRNKIQSDCI QEQLLDSAFS 420 THYLVLKDIC PSILLLAQTL FHSQDQRIIL FGSLLYKYAF KFFDTYCQQE VVGALVTHVC 480 SGTEAEVDTA LDVLLELIVL NASAMRLNAA FVKGILDYLE NMSPQQIRKI FCILSTLAFS 540 QQPGTSNHIQ DDMHLVIRKQ LSSTVFKYKL IGIIGAVTMA GIMAEDRSVP SNSSQRSANV 600 SSEQRTQVTS LLQLVHSCTE HSPWASSLYY DEFANLIQER KLAPKTLEWV GQTIFNDFQD 660 AFVVDFCAAP EGDFPFPVKA LYGLEEYSTQ DGIVINLLPL FYQECAKDAS RATSQESSQR 720 SMSSLCLASH FRLLRLCVAR QHDGNLDEID GLLDCPLFLP DLEPGEKLES MSAKDRSLMC 780 SLTFLTFNWF REVVNAFCQQ TSPEMKGKVL SRLKDLVELQ GILEKYLAVI PDYVPPFASV 840 DLDTLDMMPR SSSAVAAKNR NKGKTGGKKQ KADSNKASCS DTLLTEDTSE CDMAPSGRSH 900 VDKESTGKEG KTFVSLQNYR AFFRELDIEV FSILHSGLVT KFILDTEMHT EATEVVQLGP 960 AELLFLLEDL SQKLENMLTA PFAKRICCFK NKGRQNIGFS HLHQRSVQDI VHCVVQLLTP 1020 MCNHLENIHN FFQCLGAEHL SADDKARATA QEQHTMACCY QKLLQVLHAL FAWKGFTHQS 1080 KHRLLHSALE VLSNRLKQME QDQPLEELVS QSFSYLQNFH HSVPSFQCGL YLLRLLMALL 1140 EKSAVPNQKK EKLASLAKQL LCRAWPHGEK EKNPTFNDHL HDVLYIYLEH TDNVLKAIEE 1200 ITGVGVPELV SAPKDAASST FPTLTRHTFV IFFRVMMAEL EKTVKGLQAG TAADSQQVHE 1260 EKLLYWNMAV RDFSILLNLM KVFDSYPVLH VCLKYGRRFV EAFLKQCMPL LDFSFRKHRE 1320 DVLSLLQTLQ LNTRLLHHLC GHSKIRQDTR LTKHVPLLKK SLELLVCRVK AMLVLNNCRE 1380 AFWLGTLKNR DLQGEEIISQ DPSSSESNAE DSEDGVTSHV SRNRATEDGE DEASDEQKDQ 1440 DSDESDDSSS 1451 |
|
Database | Annotation |
---|---|
CTD (Curated) (count: 3) | MESH:C531835
; Esophageal atresia with or without tracheoesophageal fistula MESH:D005199 ; Fanconi Anemia OMIM:227646 ; FANCONI ANEMIA, COMPLEMENTATION GROUP D2 |
PTM | Modification Sites |
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Phosphorylation (count: 13) (view all) | 10 SKRRRLDSEDKENLT dbPAF
100 EFVNGLESYTEDSES dbPAF 101 FVNGLESYTEDSESL dbPAF 102 VNGLESYTEDSESLR dbPAF 1403 EIISQDPSSSESNAE dbPAF 1404 IISQDPSSSESNAED dbPAF |
Network | Interaction | ||
---|---|---|---|
A | B | Source | |