| Tag | Content |
|---|---|
| UniProt Accession | CSN6_HUMAN; Q7L5N1; |
| Entrez ID | 10980 |
| GenBank Protein ID | |
| GenBank Nucleotide ID | |
| Protein Name | COP9 signalosome complex subunit 6 (SGN6) (Signalosome subunit 6) (JAB1-containing signalosome subunit 6) (MOV34 homolog) (Vpr-interacting protein) (hVIP) |
| Gene Name | COPS6; CSN6; HVIP |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Has some glucocorticoid receptor-responsive activity. Stabilizes RFWD2/COP1 through reducing RFWD2 auto-ubiquitination and decelerating RFWD2 turnover rate, hence regulates the ubiquitination of RFWD2 targets. |
| Sequence (Fasta) | MAAAAAAAAA TNGTGGSSGM EVDAAVVPSV MACGVTGSVS VALHPLVILN ISDHWIRMRS 60 QEGRPVQVIG ALIGKQEGRN IEVMNSFELL SHTVEEKIII DKEYYYTKEE QFKQVFKELE 120 FLGWYTTGGP PDPSDIHVHK QVCEIIESPL FLKLNPMTKH TDLPVSVFES VIDIINGEAT 180 MLFAELTYTL ATEEAERIGV DHVARMTATG SGENSTVAEH LIAQHSAIKM LHSRVKLILE 240 YVKASEAGEV PFNHEILREA YALCHCLPVL STDKFKTDFY DQCNDVGLMA YLGTITKTCN 300 TMNQFVNKFN VLYDRQGIGR RMRGLFF 328 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 1) | MESH:D015658 ; HIV Infections |
| DisGeNet (Curated) (count: 1) | C0019693; HIV Infections |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 9) (view all) | 105 IIIDKEYYYTKEEQF dbPAF
106 IIDKEYYYTKEEQFK dbPAF 148 QVCEIIESPLFLKLN dbPAF 241 RVKLILEYVKASEAG dbPAF 280 DKFKTDFYDQCNDVG dbPAF 298 YLGTITKTCNTMNQF dbPAF |
| Acetylation (count: 3) | 108 DKEYYYTKEEQFKQV PLMD
274 LPVLSTDKFKTDFYD PLMD 308 TMNQFVNKFNVLYDR PLMD |
| Ubiquitination (count: 14) (view all) | 102 EEKIIIDKEYYYTKE PLMD
108 DKEYYYTKEEQFKQV PLMD 113 YTKEEQFKQVFKELE PLMD 117 EQFKQVFKELEFLGW PLMD 140 PSDIHVHKQVCEIIE PLMD 153 IESPLFLKLNPMTKH PLMD |
| Network | Interaction | ||
|---|---|---|---|
| A | B | Source | |