| Tag | Content |
|---|---|
| UniProt Accession | IF2A_MOUSE; Q6ZWX6; |
| Entrez ID | 13665 |
| GenBank Protein ID | |
| GenBank Nucleotide ID | |
| Protein Name | Eukaryotic translation initiation factor 2 subunit 1 (Eukaryotic translation initiation factor 2 subunit alpha) (eIF-2-alpha) (eIF-2A) (eIF-2alpha) |
| Gene Name | Eif2s1; Eif2a |
| Organism | Mus musculus |
| NCBI Taxa ID | 10090 |
| Functional Description | Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B (By similarity). |
| Sequence (Fasta) | MPGLSCRFYQ HKFPEVEDVV MVNVRSIAEM GAYVSLLEYN NIEGMILLSE LSRRRIRSIN 60 KLIRIGRNEC VVVIRVDKEK GYIDLSKRRV SPEEAIKCED KFTKSKTVYS ILRHVAEVLE 120 YTKDEQLESL FQRTAWVFDD KYKRPGYGAY DAFKHAVSDP SILDSLDLNE DEREVLINNI 180 NRRLTPQAVK IRADIEVACY GYEGIDAVKE ALRAGLNCST ETMPIKINLI APPRYVMTTT 240 TLERTEGLSV LNQAMAVIKE KIEEKRGVFN VQMEPKVVTD TDETELARQL ERLERENAEV 300 DGDDDAEEME AKAED 316 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 5) | MESH:D000544
; Alzheimer Disease MESH:D003072 ; Cognition Disorders MESH:D009410 ; Nerve Degeneration MESH:D013226 ; Status Epilepticus MESH:D012516 ; Osteosarcoma |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 9) (view all) | 147 DKYKRPGYGAYDAFK dbPAF
150 KRPGYGAYDAFKHAV dbPAF 158 DAFKHAVSDPSILDS dbPAF 161 KHAVSDPSILDSLDL dbPAF 165 SDPSILDSLDLNEDE dbPAF 185 NNINRRLTPQAVKIR dbPAF |
| Acetylation (count: 4) | 106 EDKFTKSKTVYSILR PLMD
123 AEVLEYTKDEQLESL PLMD 141 TAWVFDDKYKRPGYG PLMD 259 NQAMAVIKEKIEEKR PLMD |
| Ubiquitination (count: 4) | 101 EAIKCEDKFTKSKTV PLMD
106 EDKFTKSKTVYSILR PLMD 141 TAWVFDDKYKRPGYG PLMD 259 NQAMAVIKEKIEEKR PLMD |
| Malonylation (count: 1) | 61 RRIRSINKLIRIGRN PLMD |
| Network | Interaction | ||
|---|---|---|---|
| A | B | Source | |