Q6X936

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession KIRR1_RAT; Q6X936;
Entrez ID 310695
GenBank Protein ID NM_207606.1; XM_006232677.3;
GenBank Nucleotide ID NP_997489.1; XP_006232739.1;
Protein Name Kin of IRRE-like protein 1 (Kin of irregular chiasm-like protein 1) (Nephrin-like protein 1)
Gene Name Kirrel1; Kirrel; Neph1
Organism Rattus norvegicus
NCBI Taxa ID 10116
Functional DescriptionPlays a significant role in the normal development and function of the glomerular permeability. Is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1 (By similarity).
Sequence
(Fasta)
MTLENRSTCL MTCQSSLLPK KPRFLSQKMW APHLVVAYLI FVTLALALPG TQTRFSQEPA 60
DQTVVAGHRA VLPCVLLNYS GIVQWTKDGL ALGMGQGLKA WPRYRVVGSA DAGQYNLEIT 120
DAELSDDASY ECQATEAALR SRRAKLTVLI PPEDTRIDGG PVILLQAGTP YNLTCRAFNA 180
KPAATIIWFR DGTQQEGAVT STELLKDGKR ETTISQLLIQ PTDLDIGRVF TCRSMNEAIP 240
NGKETSIELD VHHPPTVTLS IEPQTVLEGE RVIFTCQATA NPEILGYRWA KGGFLIEDAH 300
ESRYETNVDY SFFTEPVSCE VYNKVGSTNV STLVNVHFAP RIVVYPKPTT TDIGSDVTLT 360
CVWVGNPPLT LTWTKKDSNM VLSNSNQLLL KSVTQADAGT YTCRAIVPRI GVAEREVPLY 420
VNGPPIISSE AVQFAVRGDG GKVECFIGST PPPDRIAWAW KENFLEVGTL ERYTVERTNS 480
GSGVLSTLTI NNVMEADFQT HYNCTAWNSF GPGTAIIQLE EREVLPVGII AGATIGAGIL 540
LVFSFAALVF FLYRRRKGSR KDVTLRKLDI KVETVNREPL TMHSDREDDT TSISTATRVM 600
KAIYSSFKDD VDLKQDLHCD TIETREEYEM KDPTNGYYNV RAHEDRPSSR AVLYADYRAP 660
GPTRFDGRPS SRLSHSSGYA QLNTYSRAPA SDYGTEPTPS GPSAPGGTDT TSQLSYENYE 720
KFNSHPFPGA AGYPTYRLGY PQAPPSGLER TPYEAYDPIG KYATATRFSY TSQHSDYGQR 780
FQQRMQTHV

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Tyrosine PhosphorylationKidney diseaseUY63718258597
[Reference]: Phosphorylation of tyrosine 637 is significantly up-regulated in in vivo models of podocyte injury.?
2Tyrosine PhosphorylationKidney diseaseUY63818258597
[Reference]: Both tyrosine 637 and 638 of Neph1 are crucial for Neph1-Grb2 binding.


※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 5)
637       MKDPTNGYYNVRAHE     dbPAF
638       KDPTNGYYNVRAHED     dbPAF
654       PSSRAVLYADYRAPG     dbPAF
657       RAVLYADYRAPGPTR     dbPAF
715       TDTTSQLSYENYEKF     dbPAF