Tag | Content |
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UniProt Accession | CRTC1_HUMAN; Q6UUV9; |
Entrez ID | 23373 |
GenBank Protein ID | NM_001098482.1; NM_015321.2; |
GenBank Nucleotide ID | NP_001091952.1; NP_056136.2; |
Protein Name | CREB-regulated transcription coactivator 1 (Mucoepidermoid carcinoma translocated protein 1) (Transducer of regulated cAMP response element-binding protein 1) (TORC-1) (Transducer of CREB protein 1) |
Gene Name | CRTC1; KIAA0616; MECT1; TORC1; WAMTP1 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activ(view all) |
Sequence (Fasta) | MATSNNPRKF SEKIALHNQK QAEETAAFEE VMKDLSLTRA ARLQLQKSQY LQLGPSRGQY 60 YGGSLPNVNQ IGSGTMDLPF QTPFQSSGLD TSRTTRHHGL VDRVYRERGR LGSPHRRPLS 120 VDKHGRQADS CPYGTMYLSP PADTSWRRTN SDSALHQSTM TPTQPESFSS GSQDVHQKRV 180 LLLTVPGMEE TTSEADKNLS KQAWDTKKTG SRPKSCEVPG INIFPSADQE NTTALIPATH 240 NTGGSLPDLT NIHFPSPLPT PLDPEEPTFP ALSSSSSTGN LAANLTHLGI GGAGQGMSTP 300 GSSPQHRPAG VSPLSLSTEA RRQQASPTLS PLSPITQAVA MDALSLEQQL PYAFFTQAGS 360 QQPPPQPQPP PPPPPASQQP PPPPPPQAPV RLPPGGPLLP SASLTRGPQP PPLAVTVPSS 420 LPQSPPENPG QPSMGIDIAS APALQQYRTS AGSPANQSPT SPVSNQGFSP GSSPQHTSTL 480 GSVFGDAYYE QQMAARQANA LSHQLEQFNM MENAISSSSL YSPGSTLNYS QAAMMGLTGS 540 HGSLPDSQQL GYASHSGIPN IILTVTGESP PSLSKELTSS LAGVGDVSFD SDSQFPLDEL 600 KIDPLTLDGL HMLNDPDMVL ADPATEDTFR MDRL 635 |
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Database | Annotation |
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Cancer Gene Census | salivary gland mucoepidermoid |
CTD (Curated) (count: 1) | MESH:C562730 ; Adenocarcinoma Of Esophagus |
DisGeNet (Curated) (count: 2) | C0279628; Adenocarcinoma Of Esophagus
C0525045; Mood Disorders |
GWASdb (count: 7) (view all) | rs10419226; Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); Barrett's esophagus|esophageal carcinoma
rs10419226; Barrett's esophagus; Barrett's esophagus rs10419226; Esophageal adenocarcinoma; esophageal carcinoma rs10423674; Menarche (age at onset); obesity|type 2 diabetes mellitus|cardiovascular system disease|osteoporosis|breast cancer|Alzheimer's disease rs10423674; Esophageal adenocarcinoma; esophageal carcinoma rs10423674; Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); Barrett's esophagus|esophageal carcinoma |
PTM | Modification Sites |
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Phosphorylation (count: 22) (view all) | 113 RERGRLGSPHRRPLS dbPAF
139 PYGTMYLSPPADTSW dbPAF 149 ADTSWRRTNSDSALH dbPAF 151 TSWRRTNSDSALHQS dbPAF 153 WRRTNSDSALHQSTM dbPAF 158 SDSALHQSTMTPTQP dbPAF |
Ubiquitination (count: 1) | 47 AARLQLQKSQYLQLG PLMD |
Network | Interaction | ||
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A | B | Source | |