Q6UUV9

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession CRTC1_HUMAN; Q6UUV9;
Entrez ID 23373
GenBank Protein ID NM_001098482.1; NM_015321.2;
GenBank Nucleotide ID NP_001091952.1; NP_056136.2;
Protein Name CREB-regulated transcription coactivator 1 (Mucoepidermoid carcinoma translocated protein 1) (Transducer of regulated cAMP response element-binding protein 1) (TORC-1) (Transducer of CREB protein 1)
Gene Name CRTC1; KIAA0616; MECT1; TORC1; WAMTP1
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionTranscriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activ(view all)
Sequence
(Fasta)
MATSNNPRKF SEKIALHNQK QAEETAAFEE VMKDLSLTRA ARLQLQKSQY LQLGPSRGQY 60
YGGSLPNVNQ IGSGTMDLPF QTPFQSSGLD TSRTTRHHGL VDRVYRERGR LGSPHRRPLS 120
VDKHGRQADS CPYGTMYLSP PADTSWRRTN SDSALHQSTM TPTQPESFSS GSQDVHQKRV 180
LLLTVPGMEE TTSEADKNLS KQAWDTKKTG SRPKSCEVPG INIFPSADQE NTTALIPATH 240
NTGGSLPDLT NIHFPSPLPT PLDPEEPTFP ALSSSSSTGN LAANLTHLGI GGAGQGMSTP 300
GSSPQHRPAG VSPLSLSTEA RRQQASPTLS PLSPITQAVA MDALSLEQQL PYAFFTQAGS 360
QQPPPQPQPP PPPPPASQQP PPPPPPQAPV RLPPGGPLLP SASLTRGPQP PPLAVTVPSS 420
LPQSPPENPG QPSMGIDIAS APALQQYRTS AGSPANQSPT SPVSNQGFSP GSSPQHTSTL 480
GSVFGDAYYE QQMAARQANA LSHQLEQFNM MENAISSSSL YSPGSTLNYS QAAMMGLTGS 540
HGSLPDSQQL GYASHSGIPN IILTVTGESP PSLSKELTSS LAGVGDVSFD SDSQFPLDEL 600
KIDPLTLDGL HMLNDPDMVL ADPATEDTFR MDRL 635

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Serine PhosphorylationParkinson's diseaseDS21527903866
[Reference]: his neuroprotective effect of caPAK4 was mediated by phosphorylation of CRTC1 [CREB (adenosine 3',5'-monophosphate response element-binding protein)-regulated transcription coactivator] at S215.

※ Disease Cross-ref Annotation

DatabaseAnnotation
Cancer Gene Census
salivary gland mucoepidermoid
CTD (Curated)
(count: 1)
MESH:C562730 ; Adenocarcinoma Of Esophagus
DisGeNet (Curated)
(count: 2)
C0279628; Adenocarcinoma Of Esophagus
C0525045; Mood Disorders
GWASdb
(count: 7)
(view all)
rs10419226; Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); Barrett's esophagus|esophageal carcinoma
rs10419226; Barrett's esophagus; Barrett's esophagus
rs10419226; Esophageal adenocarcinoma; esophageal carcinoma
rs10423674; Menarche (age at onset); obesity|type 2 diabetes mellitus|cardiovascular system disease|osteoporosis|breast cancer|Alzheimer's disease
rs10423674; Esophageal adenocarcinoma; esophageal carcinoma
rs10423674; Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); Barrett's esophagus|esophageal carcinoma

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 22)
(view all)
113       RERGRLGSPHRRPLS     dbPAF
139       PYGTMYLSPPADTSW     dbPAF
149       ADTSWRRTNSDSALH     dbPAF
151       TSWRRTNSDSALHQS     dbPAF
153       WRRTNSDSALHQSTM     dbPAF
158       SDSALHQSTMTPTQP     dbPAF
Ubiquitination
(count: 1)
47        AARLQLQKSQYLQLG     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource