Q6U7Q0

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession ZN322_HUMAN; Q6U7Q0;
Entrez ID 79692
GenBank Protein ID NM_001242797.1; NM_001242798.1; NM_001242799.1; NM_024639.4;
GenBank Nucleotide ID NP_001229726.1; NP_001229727.1; NP_001229728.1; NP_078915.2;
Protein Name Zinc finger protein 322 (Zinc finger protein 322A) (Zinc finger protein 388) (Zinc finger protein 489)
Gene Name ZNF322; ZNF322A; ZNF388; ZNF489
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionInvolved in transcriptional regulation as an activator.
Sequence
(Fasta)		MYTSEEKCNQ RTQKRKIYNV CPRKGKKIFI HMHEIIQIDG HIYQCLECKQ NFCENLALIM 60
CERTHTGEKP YKCDMCEKTF VQSSDLTSHQ RIHNYEKPYK CSKCEKSFWH HLALSGHQRT 120
HAGKKFYTCD ICGKNFGQSS DLLVHQRSHT GEKPYLCSEC DKCFSRSTNL IRHRRTHTGE 180
KPFKCLECEK AFSGKSDLIS HQRTHTGERP YKCNKCEKSY RHRSAFIVHK RVHTGEKPYK 240
CGACEKCFGQ KSDLIVHQRV HTGEKPYKCL ECMRSFTRSA NLIRHQATHT HTFKCLEYEK 300
SFNCSSDLIV HQRIHMEEKP HQWSACESGF LLGMDFVAQQ KMRTQTEELH YKYTVCDKSF 360
HQSSALLQHQ TVHIGEKPFV CNVSEKGLEL SPPHASEASQ MS 403

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Serine PhosphorylationLung cancer/carcinomaDS39128581525
[Reference]: CK1? and GSK3? kinases sequentially phosphorylate ZNF322A at serine-396 and then serine-391. Our results reveal a new mechanism of ZNF322A oncoprotein destruction regulated by the CK1?/GSK3?/FBXW7? axis. Deregulation of this signaling axis results in ZNF322A overexpression and promotes cancer progression.

※ Disease Cross-ref Annotation

DatabaseAnnotation
GWASdb
(count: 6)		rs2504571; Multiple complex diseases; Null
rs2498380; Multiple complex diseases; Null
rs2498380; Other erythrocyte phenotypes; hematopoietic system disease
rs2498380; Red blood cell traits; hematopoietic system disease
rs9379907; Pulmonary function; asthma|chronic obstructive pulmonary disease
rs13210025; Pulmonary function; asthma|chronic obstructive pulmonary disease

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 10)
(view all)		 176       NLIRHRRTHTGEKPF     dbPAF
178       IRHRRTHTGEKPFKC     dbPAF
234       IVHKRVHTGEKPYKC     dbPAF
262       IVHQRVHTGEKPYKC     dbPAF
391       SEKGLELSPPHASEA     dbPAF
64        ALIMCERTHTGEKPY     dbPAF
Ubiquitination
(count: 2)		 190       FKCLECEKAFSGKSD     PLMD
251       CEKCFGQKSDLIVHQ     PLMD
Sumoylation
(count: 2)		 184       HTGEKPFKCLECEKA     PLMD
195       CEKAFSGKSDLISHQ     PLMD