| Tag | Content |
|---|---|
| UniProt Accession | CXA1_RABIT; Q6TYA7; |
| Entrez ID | 100008935 |
| GenBank Protein ID | NM_001198948.1; XM_008263297.2; |
| GenBank Nucleotide ID | NP_001185877.1; XP_008261519.1; |
| Protein Name | Gap junction alpha-1 protein (Connexin-43) (Cx43) |
| Gene Name | GJA1 |
| Organism | Oryctolagus cuniculus |
| NCBI Taxa ID | 9986 |
| Functional Description | Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract. May play a role in cell growth inhibition through the regulation of NOV expression and localization. Plays an essential role in gap junction communication in the ventricles (By similarity). |
| Sequence (Fasta) | MGDWSALGKL LDKVQAYSTA GGKVWLSVLF IFRILLLGTA VESAWGDEQS AFRCNTQQPG 60 CENVCYDKSF PISHVRFWVL QIIFVSVPTL LYLAHVFYVM RKEEKLNKKE EELKVAQTDG 120 VNVEMHLKQI EIKKFKYGIE EHGKVKMRGG LLRTYIISIL FKSVFEVAFL LIQWYIYGFS 180 LSAVYTCKRD PCPHQVDCFL SRPTEKTIFI IFMLVVSLVS LALNIIELFY VFFKGVKDRV 240 KGKSDPYHAT TGPLSPSKDC GSPKYAYFNG CSSPTAPLSP MSPPGYKLVT GDRNNSSCRN 300 YNKQASEQNW ANYSAEQNRM GQAGSTISNS HAQPFDFPDD NQNSKKLAAG HELQPLAIVD 360 QRPSSRASSR ASSRPRPDDL EI 383 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 19) (view all) | MESH:D000236
; Adenoma MESH:D001145 ; Arrhythmias, Cardiac MESH:C562831 ; Atrioventricular Septal Defect MESH:D001321 ; Autistic Disorder MESH:C537660 ; Basaran Yilmaz syndrome MESH:D003323 ; Coronary Aneurysm |
| PTM | Modification Sites |
|---|---|