| Tag | Content |
|---|---|
| UniProt Accession | BCR_MOUSE; Q6PAJ1; |
| Entrez ID | 110279 |
| GenBank Protein ID | |
| GenBank Nucleotide ID | |
| Protein Name | Breakpoint cluster region protein (EC 2.7.11.1) |
| Gene Name | Bcr; Kiaa3017 |
| Organism | Mus musculus |
| NCBI Taxa ID | 10090 |
| Functional Description | GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity (By similarity). |
| Sequence (Fasta) | MVDSVGFAEA WRAQFPDSEP PRMELRSVGD IEQELERCKA SIRRLEQEVN QERFRMIYLQ 60 TLLAKEKKSY DRQRWGFRRA AQPPDGAAEP RASAPRPPPA PADGADPAPV EESEARPDGE 120 GSPSKGRSAS ARRPAAAASA DRDDRGPPTS VAALRSNFEK IRKGPAQPGS ADAEKPFYVN 180 VEFHHERGLV KVNDKEVSDR ISSLGSQAMQ MERKKSQQSA GQGLGEAPRP HYRGRSSESS 240 CGLDGDYEDA ELNPRFLKDN LINANGGNRP PWPPLEYQPY QSIYVGGMMV EGEGKSPLLR 300 SQSTSEQEKR LTWPRRSYSP RSFEDSGGGY TPDCSSNENL TSSEEDFSSG QSSRVSPSPT 360 TYRMFRDKSR SPSQNSQQSF DSSSPPTPQC QKRHRQCQVV VSEATIVGVR KTGQIWPSDG 420 DSTFQGEADS SFGTPPGYGC AADQAEEQRR HQDGLPYIDD SPSSSPHLSS KGRGSLASGA 480 LDPTKVSELD LEKGLEMRKW VLSGILASEE TYLSHLEALL LPMKPLKAAA TTSQPVLTSQ 540 QIETIFFKVP ELYEIHKEFY DGLFPRVQQW SHQQRVGDLF QKLASQLGVY RAFVDNYGVA 600 METAEKCCQA NAQFAEISEN LRARSNKDVK DSTTKNSLET LLYKPVDRVT RSTLVLHDLL 660 KHTPSSHPDH SLLQDALRIS QNFLSSINEE ITPRRQSMTV KKGEHRQLLK DSFMVELVEG 720 ARKLRHIFLF TDLLLCTKLK KQSGGKTQQY DCKWYIPLTD LSFQMVDELE ALPNIPLVPD 780 EELDALKIKI SQIKSDIQRE KRANKGSKVM ERLRKKLSEQ ESLLLLMSPS MAFRVHSRNG 840 KSYTFLISSD YERAEWRESI REQQKKCFKS FSLTSVELQM LTNSCVKLQT VHHIPLTINK 900 EDDESPGLYG FLHVIVHSAT GFKQSSNLYC TLEVDSFGYF VNKAKTRVYR DTTEPNWNEE 960 FEIELEGSQT LRILCYEKCY NKMKMTKEDG ESADKLMGKG QVQLDPQTLQ DRDWQRTVID 1020 MNGIEVKLSV KFTSREFSLK RMPSRKQTGV FGVKIAVVTK RERSKVPYIV RQCVEEIERR 1080 GMEEVGIYRV SGVATDIQAL KAAFDVNNKD VSVMMSEMDV NAIAGTLKLY FRELPEPLFT 1140 DEFYPNFAEG IALSDPVAKE SCMLNLLLSL PEANLLTFLF LLDHLKRVAE KETVNKMSLH 1200 NLATVFGPTL LRPSEKESKL PANPSQPITM TDSWSLEVMS QVQVLLYFLQ LEAIPAPDSK 1260 RQSILFSTEV 1271 |
|
||||||||||||||||||||
| Database | Annotation |
|---|---|
| CTD (Curated) (count: 7) (view all) | MESH:D001752
; Blast Crisis MESH:D015464 ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive MESH:D008106 ; Liver Cirrhosis, Experimental MESH:D009196 ; Myeloproliferative Disorders MESH:D009336 ; Necrosis MESH:D009374 ; Neoplasms, Experimental |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 49) (view all) | 113 DPAPVEESEARPDGE dbPAF
122 ARPDGEGSPSKGRSA dbPAF 124 PDGEGSPSKGRSASA dbPAF 1259 EAIPAPDSKRQSILF dbPAF 1263 APDSKRQSILFSTEV dbPAF 139 RRPAAAASADRDDRG dbPAF |
| Network | Interaction | ||
|---|---|---|---|
| A | B | Source | |