Tag | Content |
---|---|
UniProt Accession | ERAP2_HUMAN; Q6P179; |
Entrez ID | 64167 |
GenBank Protein ID | NM_001130140.2; NM_001329229.1; NM_001329233.1; NM_022350.4; |
GenBank Nucleotide ID | NP_001123612.1; NP_001316158.1; NP_001316162.1; NP_071745.1; |
Protein Name | Endoplasmic reticulum aminopeptidase 2 (EC 3.4.11.-) (Leukocyte-derived arginine aminopeptidase) (L-RAP) |
Gene Name | ERAP2; LRAP |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg and Lys. |
Sequence (Fasta) | MFHSSAMVNS HRKPMFNIHR GFYCLTAILP QICICSQFSV PSSYHFTEDP GAFPVATNGE 60 RFPWQELRLP SVVIPLHYDL FVHPNLTSLD FVASEKIEVL VSNATQFIIL HSKDLEITNA 120 TLQSEEDSRY MKPGKELKVL SYPAHEQIAL LVPEKLTPHL KYYVAMDFQA KLGDGFEGFY 180 KSTYRTLGGE TRILAVTDFE PTQARMAFPC FDEPLFKANF SIKIRRESRH IALSNMPKVK 240 TIELEGGLLE DHFETTVKMS TYLVAYIVCD FHSLSGFTSS GVKVSIYASP DKRNQTHYAL 300 QASLKLLDFY EKYFDIYYPL SKLDLIAIPD FAPGAMENWG LITYRETSLL FDPKTSSASD 360 KLWVTRVIAH ELAHQWFGNL VTMEWWNDIW LKEGFAKYME LIAVNATYPE LQFDDYFLNV 420 CFEVITKDSL NSSRPISKPA ETPTQIQEMF DEVSYNKGAC ILNMLKDFLG EEKFQKGIIQ 480 YLKKFSYRNA KNDDLWSSLS NSCLESDFTS GGVCHSDPKM TSNMLAFLGE NAEVKEMMTT 540 WTLQKGIPLL VVKQDGCSLR LQQERFLQGV FQEDPEWRAL QERYLWHIPL TYSTSSSNVI 600 HRHILKSKTD TLDLPEKTSW VKFNVDSNGY YIVHYEGHGW DQLITQLNQN HTLLRPKDRV 660 GLIHDVFQLV GAGRLTLDKA LDMTYYLQHE TSSPALLEGL SYLESFYHMM DRRNISDISE 720 NLKRYLLQYF KPVIDRQSWS DKGSVWDRML RSALLKLACD LNHAPCIQKA AELFSQWMES 780 SGKLNIPTDV LKIVYSVGAQ TTAGWNYLLE QYELSMSSAE QNKILYALST SKHQEKLLKL 840 IELGMEGKVI KTQNLAALLH AIARRPKGQQ LAWDFVRENW THLLKKFDLG SYDIRMIISG 900 TTAHFSSKDK LQEVKLFFES LEAQGSHLDI FQTVLETITK NIKWLEKNLP TLRTWLMVNT 960 961 |
|
Database | Annotation |
---|---|
CTD (Curated) (count: 1) | MESH:D003424 ; Crohn Disease |
GWASdb (count: 9) (view all) | rs1230358; Multiple complex diseases; Null
rs41506651; Multiple complex diseases; Null rs4869315; Psoriasis; psoriasis rs2248374; Juvenile idiopathic arthritis (including oligoarticular and rheumatoid factor-negative polyarticular JIA); juvenile rheumatoid arthritis rs2549794; Multiple complex diseases; Null rs2549794; Crohn's disease; Crohn's disease |
PTM | Modification Sites |
---|---|
Phosphorylation (count: 4) | 157 LLVPEKLTPHLKYYV dbPAF
506 LSNSCLESDFTSGGV dbPAF 516 TSGGVCHSDPKMTSN dbPAF 899 YDIRMIISGTTAHFS dbPAF |
Acetylation (count: 2) | 135 SRYMKPGKELKVLSY PLMD
138 MKPGKELKVLSYPAH PLMD |
Ubiquitination (count: 9) (view all) | 138 MKPGKELKVLSYPAH PLMD
155 IALLVPEKLTPHLKY PLMD 181 DGFEGFYKSTYRTLG PLMD 484 GIIQYLKKFSYRNAK PLMD 491 KFSYRNAKNDDLWSS PLMD 545 MTTWTLQKGIPLLVV PLMD |