Tag | Content |
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UniProt Accession | MK03_MOUSE; Q63844; |
Entrez ID | 26417 |
GenBank Protein ID | |
GenBank Nucleotide ID | |
Protein Name | Mitogen-activated protein kinase 3 (MAP kinase 3) (MAPK 3) (EC 2.7.11.24) (ERT2) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase isoform p44) (p44-MAPK) (MNK1) (Microtubule-associated protein 2 kinase) (p44-E |
Gene Name | Mapk3; Erk1; Prkm3 |
Organism | Mus musculus |
NCBI Taxa ID | 10090 |
Functional Description | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade p(view all) |
Sequence (Fasta) | MAAAAAAPGG GGGEPRGTAG VVPVVPGEVE VVKGQPFDVG PRYTQLQYIG EGAYGMVSSA 60 YDHVRKTRVA IKKISPFEHQ TYCQRTLREI QILLRFRHEN VIGIRDILRA PTLEAMRDVY 120 IVQDLMETDL YKLLKSQQLS NDHICYFLYQ ILRGLKYIHS ANVLHRDLKP SNLLINTTCD 180 LKICDFGLAR IADPEHDHTG FLTEYVATRW YRAPEIMLNS KGYTKSIDIW SVGCILAEML 240 SNRPIFPGKH YLDQLNHILG ILGSPSQEDL NCIINMKARN YLQSLPSKTK VAWAKLFPKS 300 DSKALDLLDR MLTFNPNKRI TVEEALAHPY LEQYYDPTDE PVAEEPFTFD MELDDLPKER 360 LKELIFQETA RFQPGAPEGP 381 |
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Database | Annotation |
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CTD (Curated) (count: 27) (view all) | MESH:D001284
; Atrophy MESH:D002545 ; Brain Ischemia MESH:D002294 ; Carcinoma, Squamous Cell MESH:D009202 ; Cardiomyopathies MESH:C566627 ; Ceroid Lipofuscinosis, Neuronal, 6 MESH:D001651 ; Cholestasis, Extrahepatic |
PTM | Modification Sites |
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Phosphorylation (count: 7) (view all) | 128 IVQDLMETDLYKLLK dbPAF
131 DLMETDLYKLLKSQQ dbPAF 199 ADPEHDHTGFLTEYV dbPAF 203 HDHTGFLTEYVATRW dbPAF 205 HTGFLTEYVATRWYR dbPAF 208 FLTEYVATRWYRAPE dbPAF |
Acetylation (count: 1) | 33 PGEVEVVKGQPFDVG PLMD |
Network | Interaction | ||
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A | B | Source | |