Tag | Content |
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UniProt Accession | KS6A1_RAT; Q63531; |
Entrez ID | 81771 |
GenBank Protein ID | |
GenBank Nucleotide ID | |
Protein Name | Ribosomal protein S6 kinase alpha-1 (S6K-alpha-1) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (p90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPK-activated protein kinase 1a) (MAPKAP kinase 1a) (MAPKAPK-1a) (Ribosomal S6 |
Gene Name | Rps6ka1; Mapkapk1a; Rsk1 |
Organism | Rattus norvegicus |
NCBI Taxa ID | 10116 |
Functional Description | Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional ac(view all) |
Sequence (Fasta) | MPLAQLKEPW PLMELVPLDP ENGQASGEEA GLQPSKDEGI LKEISITHHV KAGSEKADPS 60 HFELLKVLGQ GSFGKVFLVR KVTRPDNGHL YAMKVLKKAT LKVRDRVRTK MERDILADVN 120 HPFVVKLHYA FQTEGKLYLI LDFLRGGDLF TRLSKEVMFT EEDVKFYLAE LALGLDHLHS 180 LGIIYRDLKP ENILLDEEGH IKLTDFGLSK EAIDHEKKAY SFCGTVEYMA PEVVNRQGHT 240 HSADWWSYGV LMFEMLTGSL PFQGKDRKET MTLILKAKLG MPQFLSTEAQ SLLRALFKRN 300 PANRLGSGPD GAEEIKRHIF YSTIDWNKLY RREIKPPFKP AVAQPDDTFY FDTEFTSRTP 360 RDSPGIPPSA GAHQLFRGFS FVATGLMEDD SKPRATQAPL HSVVQQLHGK NLVFSDGYIV 420 KETIGVGSYS VCKRCVHKAT NMEYAVKVID KSKRDPSEEI EILLRYGQHP NIITLKDVYD 480 DSKHVYLVTE LMRGGELLDK ILRQKFFSER EASFVLYTIS KTVEYLHSQG VVHRDLKPSN 540 ILYVDESGNP ECLRICDFGF AKQLRAENGL LMTPCYTANF VAPEVLKRQG YDEGCDIWSL 600 GVLLYTMLAG YTPFANGPSD TPEEILTRIS SGKFTLSGGN WNTVSETAKD LVSKMLHVDP 660 HQRLTAKQVL QHPWITQKDK LPQSQLSHQD LQLVKGGMAA TYSALSSSKP TPQLKPIESS 720 ILAQRRVRKL PSTTL 736 |
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Database | Annotation |
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CTD (Curated) (count: 1) | MESH:D012751 ; Sezary Syndrome |
PTM | Modification Sites |
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Phosphorylation (count: 11) (view all) | 154 GDLFTRLSKEVMFTE dbPAF
221 DHEKKAYSFCGTVEY dbPAF 323 KRHIFYSTIDWNKLY dbPAF 359 DTEFTSRTPRDSPGI dbPAF 363 TSRTPRDSPGIPPSA dbPAF 369 DSPGIPPSAGAHQLF dbPAF |