Q63199

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession TNR6_RAT; Q63199;
Entrez ID 246097
GenBank Protein ID
GenBank Nucleotide ID
Protein Name Tumor necrosis factor receptor superfamily member 6 (Apo-1 antigen) (Apoptosis-mediating surface antigen FAS) (FASLG receptor) (CD antigen CD95)
Gene Name Fas; Apt1; Tnfrsf6
Organism Rattus norvegicus
NCBI Taxa ID 10116
Functional DescriptionReceptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both (By similarity).
Sequence
(Fasta)
MLWIMAVLPL VLAGPELNVR MQGTDSIFEG LELKRSVRET DNNCSEGLYQ VGPFCCQPCQ 60
PGERKVKDCT TSGGAPTCHP CTEGEEYTDR KHYSDKCRRC AFCDEGHGLE VETNCTRTQN 120
TKCRCKENFY CNASLCDHCY HCTSCGLEDI LEPCTRTSNT KCKKQSSNYK LLWLLILPGL 180
AILFVFIYKR YRKRQPGDPE SGIPSPESVP MNVSDVNLNK YIWRTAEKMK ICDAKKFARQ 240
HKIPESKIDE IEHNSPQDAA EQKIQLLQCW YQSHGKTGAC QALIQGLRKA NRCDIAEEIQ 300
AMVWEDHENS ISNSRNENEG QSLE 325

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1PhosphorylationHepatocellular carcinoma/Hepatocarcinoma/HepatomaA14679192
[Reference]: Additionally, in CD95-yellow fluorescent protein-transfected Huh7-hepatoma cells, ONOO(-) induced CD95 Tyr nitration and prevented CD95L-induced Tyr phosphorylation and apoptosis.
2NitrationHepatocellular carcinoma/Hepatocarcinoma/HepatomaP14679192
[Reference]: Additionally, in CD95-yellow fluorescent protein-transfected Huh7-hepatoma cells, ONOO(-) induced CD95 Tyr nitration and prevented CD96L-induced Tyr phosphorylation and apoptosis.

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 25)
(view all)
MESH:D055371 ; Acute Lung Injury
MESH:D001327 ; Autoimmune Diseases
MESH:D056735 ; Autoimmune Lymphoproliferative Syndrome
MESH:D009202 ; Cardiomyopathies
MESH:D002311 ; Cardiomyopathy, Dilated
MESH:D003921 ; Diabetes Mellitus, Experimental

※ PTM Sites

PTM Modification Sites