Tag | Content |
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UniProt Accession | TNR6_RAT; Q63199; |
Entrez ID | 246097 |
GenBank Protein ID | |
GenBank Nucleotide ID | |
Protein Name | Tumor necrosis factor receptor superfamily member 6 (Apo-1 antigen) (Apoptosis-mediating surface antigen FAS) (FASLG receptor) (CD antigen CD95) |
Gene Name | Fas; Apt1; Tnfrsf6 |
Organism | Rattus norvegicus |
NCBI Taxa ID | 10116 |
Functional Description | Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both (By similarity). |
Sequence (Fasta) | MLWIMAVLPL VLAGPELNVR MQGTDSIFEG LELKRSVRET DNNCSEGLYQ VGPFCCQPCQ 60 PGERKVKDCT TSGGAPTCHP CTEGEEYTDR KHYSDKCRRC AFCDEGHGLE VETNCTRTQN 120 TKCRCKENFY CNASLCDHCY HCTSCGLEDI LEPCTRTSNT KCKKQSSNYK LLWLLILPGL 180 AILFVFIYKR YRKRQPGDPE SGIPSPESVP MNVSDVNLNK YIWRTAEKMK ICDAKKFARQ 240 HKIPESKIDE IEHNSPQDAA EQKIQLLQCW YQSHGKTGAC QALIQGLRKA NRCDIAEEIQ 300 AMVWEDHENS ISNSRNENEG QSLE 325 |
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Database | Annotation |
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CTD (Curated) (count: 25) (view all) | MESH:D055371
; Acute Lung Injury MESH:D001327 ; Autoimmune Diseases MESH:D056735 ; Autoimmune Lymphoproliferative Syndrome MESH:D009202 ; Cardiomyopathies MESH:D002311 ; Cardiomyopathy, Dilated MESH:D003921 ; Diabetes Mellitus, Experimental |
PTM | Modification Sites |
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