Q62622

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession 4EBP1_RAT; Q62622;
Entrez ID 116636
GenBank Protein ID
GenBank Nucleotide ID
Protein Name Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) (eIF4E-binding protein 1) (Phosphorylated heat- and acid-stable protein regulated by insulin 1) (PHAS-I)
Gene Name Eif4ebp1
Organism Rattus norvegicus
NCBI Taxa ID 10116
Functional DescriptionRepressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (By similarity). Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways (PubMed:7939721).
Sequence
(Fasta)		MSAGSSCSQT PSRAIPTRRV ALGDGVQLPP GDYSTTPGGT LFSTTPGGTR IIYDRKFLME 60
CRNSPVAKTP PKDLPTIPGV TSPTSDEPPM QASQSHLHSS PEDKRAGGEE SQFEMDI 118

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1PhosphorylationPancreatic cancer/carcinoma/adenocarcinomaP14729632
[Reference]: Detailed biochemical profiling of mammalian target of rapamycin signaling in tumors, skin, and peripheral blood mononuclear cells (PBMCs), after a single administration of 5 mg/kg RAD001, indicated that RAD001 treatment blocked phosphorylation of the translational repressor eukaryotic initiation factor 4E-binding protein 1 and inactivated the translational activator ribosomal protein S6 kinase 1 (S6K1).

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 6)		MESH:D015658 ; HIV Infections
MESH:D007249 ; Inflammation
MESH:D007680 ; Kidney Neoplasms
MESH:D015470 ; Leukemia, Myeloid, Acute
MESH:D020522 ; Lymphoma, Mantle-Cell
MESH:D011230 ; Precancerous Conditions

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 14)
(view all)		 111       KRAGGEESQFEMDI*     dbPAF
12        SSCSQTPSRAIPTRR     dbPAF
33        VQLPPGDYSTTPGGT     dbPAF
35        LPPGDYSTTPGGTLF     dbPAF
36        PPGDYSTTPGGTLFS     dbPAF
44        PGGTLFSTTPGGTRI     dbPAF