| Tag | Content |
|---|---|
| UniProt Accession | SMAD2_MOUSE; Q62432; |
| Entrez ID | 17126 |
| GenBank Protein ID | NM_001252481.1; NM_001311070.1; NM_010754.5; XM_006525699.2; XM_017317842.1; |
| GenBank Nucleotide ID | NP_001239410.1; NP_001297999.1; NP_034884.2; XP_006525762.1; XP_017173331.1; |
| Protein Name | Mothers against decapentaplegic homolog 2 (MAD homolog 2) (Mothers against DPP homolog 2) (Mad-related protein 2) (mMad2) (SMAD family member 2) (SMAD 2) (Smad2) |
| Gene Name | Smad2; Madh2; Madr2 |
| Organism | Mus musculus |
| NCBI Taxa ID | 10090 |
| Functional Description | Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity). |
| Sequence (Fasta) | MSSILPFTPP VVKRLLGWKK SAGGSGGAGG GEQNGQEEKW CEKAVKSLVK KLKKTGRLDE 60 LEKAITTQNC NTKCVTIPST CSEIWGLSTA NTVDQWDTTG LYSFSEQTRS LDGRLQVSHR 120 KGLPHVIYCR LWRWPDLHSH HELKAIENCE YAFNLKKDEV CVNPYHYQRV ETPVLPPVLV 180 PRHTEILTEL PPLDDYTHSI PENTNFPAGI EPQSNYIPET PPPGYISEDG ETSDQQLNQS 240 MDTGSPAELS PTTLSPVNHS LDLQPVTYSE PAFWCSIAYY ELNQRVGETF HASQPSLTVD 300 GFTDPSNSER FCLGLLSNVN RNATVEMTRR HIGRGVRLYY IGGEVFAECL SDSAIFVQSP 360 NCNQRYGWHP ATVCKIPPGC NLKIFNNQEF AALLAQSVNQ GFEAVYQLTR MCTIRMSFVK 420 GWGAEYRRQT VTSTPCWIEL HLNGPLQWLD KVLTQMGSPS VRCSSMS 468 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 6) | MESH:C535662
; Acromicric dysplasia MESH:C566858 ; Copper-Overload Cirrhosis MESH:D019465 ; Craniofacial Abnormalities MESH:D006521 ; Hepatitis, Chronic MESH:D008106 ; Liver Cirrhosis, Experimental MESH:D020257; Ventricular Remodeling |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 10) (view all) | 102 QWDTTGLYSFSEQTR dbPAF
172 YHYQRVETPVLPPVL dbPAF 3 *****MSSILPFTPP dbPAF 351 EVFAECLSDSAIFVQ dbPAF 430 GAEYRRQTVTSTPCW dbPAF 433 YRRQTVTSTPCWIEL dbPAF |
| Acetylation (count: 1) | 420 TIRMSFVKGWGAEYR PLMD |
| Malonylation (count: 2) | 420 TIRMSFVKGWGAEYR PLMD
43 QEEKWCEKAVKSLVK PLMD |