Q62165

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession DAG1_MOUSE; Q62165;
Entrez ID 13138
GenBank Protein ID NM_001276481.1; NM_001276482.1; NM_001276485.1; NM_001276486.1; NM_001276492.1; NM_001276493.1; NM_010017.4; XM_006511636.2;
GenBank Nucleotide ID NP_001263410.1; NP_001263411.1; NP_001263414.1; NP_001263415.1; NP_001263421.1; NP_001263422.1; NP_034147.1; XP_006511699.1;
Protein Name Dystroglycan (Dystrophin-associated glycoprotein 1) [Cleaved into: Alpha-dystroglycan (Alpha-DG); Beta-dystroglycan (Beta-DG)]
Gene Name Dag1; Dag-1
Organism Mus musculus
NCBI Taxa ID 10090
Functional DescriptionThe dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sacrolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.;Alpha-dystroglycan is an extracellular peripheral glycoprotein that acts as a receptor for both extracellular matrix proteins containing laminin-G domains, and for certain adenoviruses. Receptor for laminin-2 (LAMA2) and agrin in peripheral nerve Schwann cells. Also receptor for lymphocytic choriomeningitis virus, Old World Lassa fever virus, and clade C New World arenaviruses.;Beta-dystroglycan is a transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity (By similarity).
Sequence
(Fasta)
MSVDNWLLHP LWGQTFLLLL SVAVAQAHWP SEPSEAVRDW KNQLEASMHS VLSDFQEAVP 60
TVVGIPDGTA VVGRSFRVSI PTDLIASSGE IIKVSAAGKE ALPSWLHWDP HSHILEGLPL 120
DTDKGVHYIS VSAARLGANG SHVPQTSSVF SIEVYPEDHN EPQSVRAASS DPGEVVPSAC 180
AADEPVTVLT VILDADLTKM TPKQRIDLLN RMQSFSEVEL HNMKLVPVVN NRLFDMSAFM 240
AGPGNAKKVV ENGALLSWKL GCSLNQNSVP DIRGVETPAR EGAMSAQLGY PVVGWHIANK 300
KPTLPKRLRR QIHATPTPVT AIGPPTTAIQ EPPSRIVPTP TSPAIAPPTE TMAPPVRDPV 360
PGKPTVTIRT RGAIIQTPTL GPIQPTRVSE AGTTVPGQIR PTLTIPGYVE PTAVITPPTT 420
TTKKPRVSTP KPATPSTDSS TTTTRRPTKK PRTPRPVPRV TTKAPITRLE TASPPTRIRT 480
TTSGVPRGGE PNQRPELKNH IDRVDAWVGT YFEVKIPSDT FYDNEDTTTD KLKLTLKLRE 540
QQLVGEKSWV QFNSNSQLMY GLPDSSHVGK HEYFMHATDK GGLSAVDAFE IHVHKRPQGD 600
KAPARFKARL AGDPAPVVND IHKKIALVKK LAFAFGDRNC SSITLQNITR GSIVVEWTNN 660
TLPLEPCPKE QIIGLSRRIA DENGKPRPAF SNALEPDFKA LSIAVTGSGS CRHLQFIPVA 720
PPSPGSSAAP ATEVPDRDPE KSSEDDVYLH TVIPAVVVAA ILLIAGIIAM ICYRKKRKGK 780
LTLEDQATFI KKGVPIIFAD ELDDSKPPPS SSMPLILQEE KAPLPPPEYP NQSMPETTPL 840
NQDTVGEYTP LRDEDPNAPP YQPPPPFTAP MEGKGSRPKN MTPYRSPPPY VPP 894

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1GlycosylationMuscular dystrophyA23562821
[Reference]: Impaired viability of muscle precursor cells in muscular dystrophy with glycosylation defects and amelioration of its severe phenotype by limited gene expression.
2Tyrosine PhosphorylationDuchenne muscular dystrophyNY89022810924
[Reference]: While the Y890F substitution may prevent dystroglycan from proteasomal degradation, an increase in sarcolemmal plectin appeared to confer protection on Dag1(Y890F/Y890F)/mdx mouse muscle.

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 4)
MESH:D007835 ; Lassa Fever
OMIM:613818 ; MUSCULAR DYSTROPHY-DYSTROGLYCANOPATHY (LIMB-GIRDLE), TYPE C, 9
MESH:D011471 ; Prostatic Neoplasms
MESH:D058494 ; Walker-Warburg Syndrome

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 10)
(view all)
315       LRRQIHATPTPVTAI     dbPAF
317       RQIHATPTPVTAIGP     dbPAF
334       TAIQEPPSRIVPTPT     dbPAF
788       LTLEDQATFIKKGVP     dbPAF
810       DDSKPPPSSSMPLIL     dbPAF
811       DSKPPPSSSMPLILQ     dbPAF
Acetylation
(count: 1)
630       KKIALVKKLAFAFGD     PLMD
Ubiquitination
(count: 5)
778       ICYRKKRKGKLTLED     PLMD
780       YRKKRKGKLTLEDQA     PLMD
791       EDQATFIKKGVPIIF     PLMD
792       DQATFIKKGVPIIFA     PLMD
806       ADELDDSKPPPSSSM     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource