Q61457

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession CCNE1_MOUSE; Q61457;
Entrez ID 12447
GenBank Protein ID
GenBank Nucleotide ID
Protein Name G1/S-specific cyclin-E1
Gene Name Ccne1; Ccne
Organism Mus musculus
NCBI Taxa ID 10090
Functional DescriptionEssential for the control of the cell cycle at the G1/S (start) transition.
Sequence
(Fasta)		MPRERDSTDH SNMKEEGGSD LSVRSRKRKA NVAVFLQDPD EEIAKIDKTV KSEDSSQPWD 60
DNSACVDPCS FIPTPNKEED NELEYPRTAF QPRKIRPPRA SPLPVLNWGN REEVWRIMLN 120
KEKTYLRDEH FLQRHPLLQA RMRAVLLDWL MEVCEVYKLH RETFYLAQDF FDRYMASQHN 180
IIKTLLQLIG ISALFIASKL EEIYPPKLHQ FAYVTDGACS GDEILTMELM MMKALKWRLS 240
PLTIVSWLNV YVQVAYVNDT GEVLMPQYPQ QVFVQIAELL DLCVLDVGCL EFPYGVLAAS 300
ALYHFSSLEL MQKVSGYQWC DIEKCVKWMV PFAMVIREMG SSKLKHFRGV PMEDSHNIQT 360
HTNSLDLLDK AQAKKAILSE QNRISPPPSV VLTPPPSSKK QSSEQETE 409

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Threonine PhosphorylationLung cancer/carcinomaNT39316023597
[Reference]: Experimental mutation of site to alanine increased tumorigenesis in p53 knockout mice and susceptibility to Ras-induced lung cancer

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 7)
(view all)		MESH:D001943 ; Breast Neoplasms
MESH:D006528 ; Carcinoma, Hepatocellular
MESH:D018450 ; Disease Progression
MESH:D008527 ; Medulloblastoma
MESH:D010051 ; Ovarian Neoplasms
MESH:D012008 ; Recurrence

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 8)
(view all)		 101       KIRPPRASPLPVLNW     dbPAF
11        ERDSTDHSNMKEEGG     dbPAF
379       QAKKAILSEQNRISP     dbPAF
385       LSEQNRISPPPSVVL     dbPAF
389       NRISPPPSVVLTPPP     dbPAF
393       PPPSVVLTPPPSSKK     dbPAF