| Tag | Content |
|---|---|
| UniProt Accession | BAD_MOUSE; Q61337; |
| Entrez ID | 12015 |
| GenBank Protein ID | |
| GenBank Nucleotide ID | |
| Protein Name | Bcl2-associated agonist of cell death (BAD) (Bcl-2-binding component 6) (Bcl-xL/Bcl-2-associated death promoter) (Bcl2 antagonist of cell death) |
| Gene Name | Bad; Bbc6 |
| Organism | Mus musculus |
| NCBI Taxa ID | 10090 |
| Functional Description | Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2. Appears to act as a link between growth factor receptor signaling and the apoptotic pathways. |
| Sequence (Fasta) | MGTPKQPSLA PAHALGLRKS DPGIRSLGSD AGGRRWRPAA QSMFQIPEFE PSEQEDASAT 60 DRGLGPSLTE DQPGPYLAPG LLGSNIHQQG RAATNSHHGG AGAMETRSRH SSYPAGTEED 120 EGMEEELSPF RGRSRSAPPN LWAAQRYGRE LRRMSDEFEG SFKGLPRPKS AGTATQMRQS 180 AGWTRIIQSW WDRNLGKGGS TPSQ 205 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 3) | MESH:D002546
; Ischemic Attack, Transient MESH:D007938 ; Leukemia MESH:D011471 ; Prostatic Neoplasms |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 18) (view all) | 108 AGAMETRSRHSSYPA dbPAF
111 METRSRHSSYPAGTE dbPAF 112 ETRSRHSSYPAGTEE dbPAF 113 TRSRHSSYPAGTEED dbPAF 117 HSSYPAGTEEDEGME dbPAF 128 EGMEEELSPFRGRSR dbPAF |
| Network | Interaction | ||
|---|---|---|---|
| A | B | Source | |