Q61029

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession LAP2B_MOUSE; Q61029;
Entrez ID 21917
GenBank Protein ID NM_001080129.2; NM_001080131.2; NM_001080132.2;
GenBank Nucleotide ID NP_001073598.1; NP_001073600.1; NP_001073601.1;
Protein Name Lamina-associated polypeptide 2, isoforms beta/delta/epsilon/gamma (Thymopoietin isoforms beta/delta/epsilon/gamma) (TP beta/delta/epsilon/gamma)
Gene Name Tmpo; Lap2
Organism Mus musculus
NCBI Taxa ID 10090
Functional DescriptionMay help direct the assembly of the nuclear lamina and thereby help maintain the structural organization of the nuclear envelope. Possible receptor for attachment of lamin filaments to the inner nuclear membrane. May be involved in the control of initiation of DNA replication through its interaction with NAKAP95 (By similarity).
Sequence
(Fasta)		MPEFLEDPSV LTKDKLKSEL VANNVTLPAG EQRKDVYVQL YLQHLTARNR PPLAAGANSK 60
GPPDFSSDEE REPTPVLGSG ASVGRGRGAV GRKATKKTDK PRLEDKDDLD VTELSNEELL 120
DQLVRYGVNP GPIVGTTRKL YEKKLLKLRE QGTESRSSTP LPTVSSSAEN TRQNGSNDSD 180
RYSDNDEDSK IELKLEKREP LKGRAKTPVT LKQRRTEHNQ SYSQAGVTET EWTSGSSTGG 240
PLQALTREST RGSRRTPRKR VETSQHFRID GAVISESTPI AETIKASSNE SLVANRLTGN 300
FKHASSILPI TEFSDITRRT PKKPLTRAEV GEKTEERRVD RDILKEMFPY EASTPTGISA 360
SCRRPIKGAA GRPLELSDFR MEESFSSKYV PKYAPLADVK SEKTKKRRSV PMWIKMLLFA 420
LVAVFLFLVY QAMETNQGNP FTNFLQDTKI SN 453

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Threonine PhosphorylationNeuroblastomaPT7410413518
[Reference]: Here, we report nonmitotic LAP 2 beta phosphorylation sites that are phosphorylated in the native protein when purified from nuclear envelopes of mouse neuroblastoma Neuro2a cells.
2Threonine PhosphorylationNeuroblastomaPT15910413518
[Reference]: Here, we report nonmitotic LAP 2 beta phosphorylation sites that are phosphorylated in the native protein when purified from nuclear envelopes of mouse neuroblastoma Neuro2a cells.
3Serine PhosphorylationNeuroblastomaPS17610413518
[Reference]: Here, we report nonmitotic LAP 2 beta phosphorylation sites that are phosphorylated in the native protein when purified from nuclear envelopes of mouse neuroblastoma Neuro2a cells.
4Serine PhosphorylationNeuroblastomaPS17910413518
[Reference]: Here, we report nonmitotic LAP 2 beta phosphorylation sites that are phosphorylated in the native protein when purified from nuclear envelopes of mouse neuroblastoma Neuro2a cells.

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 3)		MESH:D001172 ; Arthritis, Rheumatoid
MESH:D002311 ; Cardiomyopathy, Dilated
MESH:D017202 ; Myocardial Ischemia

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 44)
(view all)		 153       LKLREQGTESRSSTP     dbPAF
155       LREQGTESRSSTPLP     dbPAF
158       QGTESRSSTPLPTVS     dbPAF
159       GTESRSSTPLPTVSS     dbPAF
165       STPLPTVSSSAENTR     dbPAF
167       PLPTVSSSAENTRQN     dbPAF
Acetylation
(count: 7)
(view all)		 106       DKPRLEDKDDLDVTE     PLMD
17        VLTKDKLKSELVANN     PLMD
206       EPLKGRAKTPVTLKQ     PLMD
212       AKTPVTLKQRRTEHN     PLMD
302       NRLTGNFKHASSILP     PLMD
333       TRAEVGEKTEERRVD     PLMD
Ubiquitination
(count: 7)
(view all)		 212       AKTPVTLKQRRTEHN     PLMD
285       TPIAETIKASSNESL     PLMD
302       NRLTGNFKHASSILP     PLMD
333       TRAEVGEKTEERRVD     PLMD
388       MEESFSSKYVPKYAP     PLMD
392       FSSKYVPKYAPLADV     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource