Tag | Content |
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UniProt Accession | PML_MOUSE; Q60953; |
Entrez ID | 18854 |
GenBank Protein ID | NM_001311088.1; NM_008884.5; NM_178087.4; |
GenBank Nucleotide ID | NP_001298017.1; NP_032910.3; NP_835188.2; |
Protein Name | Protein PML |
Gene Name | Pml |
Organism | Mus musculus |
NCBI Taxa ID | 10090 |
Functional Description | Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms. Acts as the scaffold of PML-NBs allowing other proteins to shuttle in and out, a process which is regulated by SUMO-mediated modifications and interactions. Positively regulates p53/TP53 by acting at different levels (by promoting its acetylation and phosphorylation and by inhibiting its MDM2-dependent de(view all) |
Sequence (Fasta) | METEPVSVQK VPAPPGSPCR QQDSALTPTP TMPPPEEPSE DYEHSQSPAE QAIQEEFQFL 60 RCPSCQAQAK CPKLLPCLHT LCSGCLEAPG LQCPICKAPG QADANGEALD NVFFESLQRR 120 LAVFRQIVDA QAACTRCKGL ADFWCFECEQ LICSKCFEAH QWYLKHEARP LADLRDNSVS 180 SFLDSTRKSN IFCSNTNHRN PALTDIYCRG CAKPLCCTCA LLDRNHSHLH CDIGEEIQQW 240 HEELGTMTQT LEEQGRTFDS AHAQMCSAIG QLDHARADIE KQIRARVRQV VDYVQAQERE 300 LLEAVNDRYQ RDYQEIAGQL SCLEAVLQRI RTSGALVKRM KLYASDQEVL DMHSFLRKAL 360 CSLRQEEPQN QKVQLLTRGF EEFKLCLQDF ISCITQRINA AVASPEAASN QPEAASTHPV 420 TTSTPEDLEQ PKEVQSVQAQ ALELSKTQPV AMVKTVPGAH PVPVYAFSMQ GPTYREEASQ 480 TVGSMKRKCS HEDCSRKIIK MESTEENEDR LATSSPEQSW PSTFKATSPP HLDGTSNPES 540 TVPEKKILLP NNNHVTSDTG ETEERVVVIS SSEDSDTENL SSHELDDSSS ESSSLQLEGP 600 NSLKALDESL AEPHLEDRTL VFFDLKIDNE TQKISQLAAV NRESKFRVLI QPEAFSVYSK 660 AVSLEAGLRH FLSFLTTMHR PILACSRLWG PGLPIFFQTL SDINKLWEFQ DTISGFLAVL 720 PLIRERIPGA SSFKLGNLAK TYLARNMSER SALASVLAMR DLCCLLEISP GLPLAQHIYS 780 FSSLQCFASL QPLIQASVLP QSEARLLALH NVSFVELLNA YRTNRQEGLK KYVHYLSLQT 840 TPLSSSASTQ VAQFLQALST HMEGLLEGHA PAGAEGKAES KGCLA 886 |
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Database | Annotation |
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CTD (Curated) (count: 7) (view all) | MESH:D005909
; Glioblastoma MESH:D008114 ; Liver Neoplasms, Experimental MESH:D015473 ; Leukemia, Promyelocytic, Acute MESH:D016609 ; Neoplasms, Second Primary MESH:D010001 ; Osteitis Deformans MESH:D012559 ; Schizophrenia |
PTM | Modification Sites |
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Phosphorylation (count: 31) (view all) | 17 KVPAPPGSPCRQQDS dbPAF
27 RQQDSALTPTPTMPP dbPAF 39 MPPPEEPSEDYEHSQ dbPAF 404 RINAAVASPEAASNQ dbPAF 417 NQPEAASTHPVTTST dbPAF 42 PEEPSEDYEHSQSPA dbPAF |
Acetylation (count: 1) | 545 PESTVPEKKILLPNN PLMD |
Ubiquitination (count: 4) | 372 QEEPQNQKVQLLTRG PLMD
454 TQPVAMVKTVPGAHP PLMD 633 KIDNETQKISQLAAV PLMD 734 IPGASSFKLGNLAKT PLMD |
Network | Interaction | ||
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A | B | Source | |