Q60953

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession PML_MOUSE; Q60953;
Entrez ID 18854
GenBank Protein ID NM_001311088.1; NM_008884.5; NM_178087.4;
GenBank Nucleotide ID NP_001298017.1; NP_032910.3; NP_835188.2;
Protein Name Protein PML
Gene Name Pml
Organism Mus musculus
NCBI Taxa ID 10090
Functional DescriptionFunctions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms. Acts as the scaffold of PML-NBs allowing other proteins to shuttle in and out, a process which is regulated by SUMO-mediated modifications and interactions. Positively regulates p53/TP53 by acting at different levels (by promoting its acetylation and phosphorylation and by inhibiting its MDM2-dependent de(view all)
Sequence
(Fasta)
METEPVSVQK VPAPPGSPCR QQDSALTPTP TMPPPEEPSE DYEHSQSPAE QAIQEEFQFL 60
RCPSCQAQAK CPKLLPCLHT LCSGCLEAPG LQCPICKAPG QADANGEALD NVFFESLQRR 120
LAVFRQIVDA QAACTRCKGL ADFWCFECEQ LICSKCFEAH QWYLKHEARP LADLRDNSVS 180
SFLDSTRKSN IFCSNTNHRN PALTDIYCRG CAKPLCCTCA LLDRNHSHLH CDIGEEIQQW 240
HEELGTMTQT LEEQGRTFDS AHAQMCSAIG QLDHARADIE KQIRARVRQV VDYVQAQERE 300
LLEAVNDRYQ RDYQEIAGQL SCLEAVLQRI RTSGALVKRM KLYASDQEVL DMHSFLRKAL 360
CSLRQEEPQN QKVQLLTRGF EEFKLCLQDF ISCITQRINA AVASPEAASN QPEAASTHPV 420
TTSTPEDLEQ PKEVQSVQAQ ALELSKTQPV AMVKTVPGAH PVPVYAFSMQ GPTYREEASQ 480
TVGSMKRKCS HEDCSRKIIK MESTEENEDR LATSSPEQSW PSTFKATSPP HLDGTSNPES 540
TVPEKKILLP NNNHVTSDTG ETEERVVVIS SSEDSDTENL SSHELDDSSS ESSSLQLEGP 600
NSLKALDESL AEPHLEDRTL VFFDLKIDNE TQKISQLAAV NRESKFRVLI QPEAFSVYSK 660
AVSLEAGLRH FLSFLTTMHR PILACSRLWG PGLPIFFQTL SDINKLWEFQ DTISGFLAVL 720
PLIRERIPGA SSFKLGNLAK TYLARNMSER SALASVLAMR DLCCLLEISP GLPLAQHIYS 780
FSSLQCFASL QPLIQASVLP QSEARLLALH NVSFVELLNA YRTNRQEGLK KYVHYLSLQT 840
TPLSSSASTQ VAQFLQALST HMEGLLEGHA PAGAEGKAES KGCLA 886

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1PhosphorylationAcute promyelocytic leukaemiaP15195100
[Reference]: In addition, we found that the nucleolar localization of PML is dependent on ATR activation and phosphorylation of PML by ATR.

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 7)
(view all)
MESH:D005909 ; Glioblastoma
MESH:D008114 ; Liver Neoplasms, Experimental
MESH:D015473 ; Leukemia, Promyelocytic, Acute
MESH:D016609 ; Neoplasms, Second Primary
MESH:D010001 ; Osteitis Deformans
MESH:D012559 ; Schizophrenia

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 31)
(view all)
17        KVPAPPGSPCRQQDS     dbPAF
27        RQQDSALTPTPTMPP     dbPAF
39        MPPPEEPSEDYEHSQ     dbPAF
404       RINAAVASPEAASNQ     dbPAF
417       NQPEAASTHPVTTST     dbPAF
42        PEEPSEDYEHSQSPA     dbPAF
Acetylation
(count: 1)
545       PESTVPEKKILLPNN     PLMD
Ubiquitination
(count: 4)
372       QEEPQNQKVQLLTRG     PLMD
454       TQPVAMVKTVPGAHP     PLMD
633       KIDNETQKISQLAAV     PLMD
734       IPGASSFKLGNLAKT     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource