| Tag | Content |
|---|---|
| UniProt Accession | 4EBP1_MOUSE; Q60876; |
| Entrez ID | 13685 |
| GenBank Protein ID | |
| GenBank Nucleotide ID | |
| Protein Name | Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) (eIF4E-binding protein 1) (Phosphorylated heat- and acid-stable protein regulated by insulin 1) (PHAS-I) |
| Gene Name | Eif4ebp1 |
| Organism | Mus musculus |
| NCBI Taxa ID | 10090 |
| Functional Description | Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (By similarity). Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways (PubMed:7629182). |
| Sequence (Fasta) | MSAGSSCSQT PSRAIPTRRV ALGDGVQLPP GDYSTTPGGT LFSTTPGGTR IIYDRKFLME 60 CRNSPVAKTP PKDLPAIPGV TSPTSDEPPM QASQSQLPSS PEDKRAGGEE SQFEMDI 118 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 6) | MESH:D015658
; HIV Infections MESH:D007249 ; Inflammation MESH:D007680 ; Kidney Neoplasms MESH:D015470 ; Leukemia, Myeloid, Acute MESH:D020522 ; Lymphoma, Mantle-Cell MESH:D011230 ; Precancerous Conditions |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 27) (view all) | 10 AGSSCSQTPSRAIPT dbPAF
100 SQSQLPSSPEDKRAG dbPAF 111 KRAGGEESQFEMDI* dbPAF 12 SSCSQTPSRAIPTRR dbPAF 2 ******MSAGSSCSQ dbPAF 33 VQLPPGDYSTTPGGT dbPAF |
| Acetylation (count: 1) | 56 TRIIYDRKFLMECRN PLMD |
| Network | Interaction | ||
|---|---|---|---|
| A | B | Source | |