Q60829

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession PPR1B_MOUSE; Q60829;
Entrez ID 19049
GenBank Protein ID NM_001313970.1; NM_144828.2;
GenBank Nucleotide ID NP_001300899.1; NP_659077.1;
Protein Name Protein phosphatase 1 regulatory subunit 1B (DARPP-32) (Dopamine- and cAMP-regulated neuronal phosphoprotein)
Gene Name Ppp1r1b
Organism Mus musculus
NCBI Taxa ID 10090
Functional DescriptionInhibitor of protein-phosphatase 1.
Sequence
(Fasta)		MDPKDRKKIQ FSVPAPPSQL DPRQVEMIRR RRPTPAMLFR VSEHSSPEEE ASPHQRTSGE 60
GHHPKSKRPN PCAYTPPSLK AVQHLQTISN LSENQASEEE DELGELRELG YPQEDDEEDE 120
DEEEDEEEDS QAEVLKGSRG TVGQKPTCGR GLEGPWERPP PLDEPQRDGN SEDQVEGRAT 180
LSEPGEEPQH PSPP 195

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Threonine PhosphorylationHuntington's diseaseDT3410829080
[Reference]: Severe deficiencies in dopamine signaling in presymptomatic Huntington's disease mice.
2Threonine PhosphorylationDepression?UT3419834457
[Reference]: In the striatum of the knock-in mice, DARPP-32 phosphorylation at Thr 34, which is important for the regulation of depression-related behaviour, is increased.?

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 2)		MESH:D002375 ; Catalepsy
MESH:D020820 ; Dyskinesias

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 10)
(view all)		 130       EEDEEEDSQAEVLKG     dbPAF
141       VLKGSRGTVGQKPTC     dbPAF
192       GEEPQHPSPP*****     dbPAF
34        MIRRRRPTPAMLFRV     dbPAF
42        PAMLFRVSEHSSPEE     dbPAF
45        LFRVSEHSSPEEEAS     dbPAF