Q60795

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession NF2L2_MOUSE; Q60795;
Entrez ID 18024
GenBank Protein ID
GenBank Nucleotide ID
Protein Name Nuclear factor erythroid 2-related factor 2 (NF-E2-related factor 2) (NFE2-related factor 2) (Nuclear factor, erythroid derived 2, like 2)
Gene Name Nfe2l2; Nrf-2; Nrf2
Organism Mus musculus
NCBI Taxa ID 10090
Functional DescriptionTranscription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.
Sequence
(Fasta)
MMDLELPPPG LQSQQDMDLI DILWRQDIDL GVSREVFDFS QRQKDYELEK QKKLEKERQE 60
QLQKEQEKAF FAQFQLDEET GEFLPIQPAQ HIQTDTSGSA SYSQVAHIPK QDALYFEDCM 120
QLLAETFPFV DDHESLALDI PSHAESSVFT APHQAQSLNS SLEAAMTDLS SIEQDMEQVW 180
QELFSIPELQ CLNTENKQLA DTTAVPSPEA TLTEMDSNYH FYSSISSLEK EVGNCGPHFL 240
HGFEDSFSSI LSTDDASQLT SLDSNPTLNT DFGDEFYSAF IAEPSDGGSM PSSAAISQSL 300
SELLDGTIEG CDLSLCKAFN PKHAEGTMEF NDSDSGISLN TSPSRASPEH SVESSIYGDP 360
PPGFSDSEME ELDSAPGSVK QNGPKAQPAH SPGDTVQPLS PAQGHSAPMR ESQCENTTKK 420
EVPVSPGHQK APFTKDKHSS RLEAHLTRDE LRAKALHIPF PVEKIINLPV DDFNEMMSKE 480
QFNEAQLALI RDIRRRGKNK VAAQNCRKRK LENIVELEQD LGHLKDEREK LLREKGENDR 540
NLHLLKRRLS TLYLEVFSML RDEDGKPYSP SEYSLQQTRD GNVFLVPKSK KPDTKKN 598

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Serine PhosphorylationDiabetes mellitusDS4024967692
[Reference]: The latter was reflected by the increased phosphorylation of Nrf2 at Ser40 and expression of Nrf2 downstream antioxidants at mRNA and protein levels. These results suggest that type 1 diabetes significantly induced testicular apoptosis and damage along with increasing oxidative stress and cell death and suppressing Nrf2 expression and function.

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 36)
(view all)
MESH:D058186 ; Acute Kidney Injury
MESH:D055371 ; Acute Lung Injury
MESH:C538231 ; Adenocarcinoma of lung
MESH:D063646 ; Carcinogenesis
MESH:D006528 ; Carcinoma, Hepatocellular
MESH:D021441 ; Carcinoma, Pancreatic Ductal

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 12)
(view all)
335       MEFNDSDSGISLNTS     dbPAF
338       NDSDSGISLNTSPSR     dbPAF
342       SGISLNTSPSRASPE     dbPAF
347       NTSPSRASPEHSVES     dbPAF
351       SRASPEHSVESSIYG     dbPAF
355       PEHSVESSIYGDPPP     dbPAF
Acetylation
(count: 2)
588       GNVFLVPKSKKPDTK     PLMD
591       FLVPKSKKPDTKKN*     PLMD