Q5S007

PTMD Annotation Information

※ Protein Information

Tag	Content
UniProt Accession	LRRK2_HUMAN; Q5S007;
Entrez ID	120892
GenBank Protein ID
GenBank Nucleotide ID
Protein Name	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (Dardarin)
Gene Name	LRRK2; PARK8
Organism	Homo sapiens
NCBI Taxa ID	9606
Functional Description	Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes. Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). Plays a role in synaptic vesicle trafficking. Phosphorylates PRDX3. Has GTPase activity. May play a role in the phosphorylation of proteins central to Parkinson disease. Functional Description Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes. Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). Plays a role in synaptic vesicle trafficking. Phosphorylates PRDX3. Has GTPase activity. May play a role in the phosphorylation of proteins central to Parkinson disease.
Sequence (Fasta)	MASGSCQGCE EDEETLKKLI VRLNNVQEGK QIETLVQILE DLLVFTYSER ASKLFQGKNI 60 HVPLLIVLDS YMRVASVQQV GWSLLCKLIE VCPGTMQSLM GPQDVGNDWE VLGVHQLILK 120 MLTVHNASVN LSVIGLKTLD LLLTSGKITL LILDEESDIF MLIFDAMHSF PANDEVQKLG 180 CKALHVLFER VSEEQLTEFV ENKDYMILLS ALTNFKDEEE IVLHVLHCLH SLAIPCNNVE 240 VLMSGNVRCY NIVVEAMKAF PMSERIQEVS CCLLHRLTLG NFFNILVLNE VHEFVVKAVQ 300 QYPENAALQI SALSCLALLT ETIFLNQDLE EKNENQENDD EGEEDKLFWL EACYKALTWH 360 RKNKHVQEAA CWALNNLLMY QNSLHEKIGD EDGHFPAHRE VMLSMLMHSS SKEVFQASAN 420 ALSTLLEQNV NFRKILLSKG IHLNVLELMQ KHIHSPEVAE SGCKMLNHLF EGSNTSLDIM 480 AAVVPKILTV MKRHETSLPV QLEALRAILH FIVPGMPEES REDTEFHHKL NMVKKQCFKN 540 DIHKLVLAAL NRFIGNPGIQ KCGLKVISSI VHFPDALEML SLEGAMDSVL HTLQMYPDDQ 600 EIQCLGLSLI GYLITKKNVF IGTGHLLAKI LVSSLYRFKD VAEIQTKGFQ TILAILKLSA 660 SFSKLLVHHS FDLVIFHQMS SNIMEQKDQQ FLNLCCKCFA KVAMDDYLKN VMLERACDQN 720 NSIMVECLLL LGADANQAKE GSSLICQVCE KESSPKLVEL LLNSGSREQD VRKALTISIG 780 KGDSQIISLL LRRLALDVAN NSICLGGFCI GKVEPSWLGP LFPDKTSNLR KQTNIASTLA 840 RMVIRYQMKS AVEEGTASGS DGNFSEDVLS KFDEWTFIPD SSMDSVFAQS DDLDSEGSEG 900 SFLVKKKSNS ISVGEFYRDA VLQRCSPNLQ RHSNSLGPIF DHEDLLKRKR KILSSDDSLR 960 SSKLQSHMRH SDSISSLASE REYITSLDLS ANELRDIDAL SQKCCISVHL EHLEKLELHQ 1020 NALTSFPQQL CETLKSLTHL DLHSNKFTSF PSYLLKMSCI ANLDVSRNDI GPSVVLDPTV 1080 KCPTLKQFNL SYNQLSFVPE NLTDVVEKLE QLILEGNKIS GICSPLRLKE LKILNLSKNH 1140 ISSLSENFLE ACPKVESFSA RMNFLAAMPF LPPSMTILKL SQNKFSCIPE AILNLPHLRS 1200 LDMSSNDIQY LPGPAHWKSL NLRELLFSHN QISILDLSEK AYLWSRVEKL HLSHNKLKEI 1260 PPEIGCLENL TSLDVSYNLE LRSFPNEMGK LSKIWDLPLD ELHLNFDFKH IGCKAKDIIR 1320 FLQQRLKKAV PYNRMKLMIV GNTGSGKTTL LQQLMKTKKS DLGMQSATVG IDVKDWPIQI 1380 RDKRKRDLVL NVWDFAGREE FYSTHPHFMT QRALYLAVYD LSKGQAEVDA MKPWLFNIKA 1440 RASSSPVILV GTHLDVSDEK QRKACMSKIT KELLNKRGFP AIRDYHFVNA TEESDALAKL 1500 RKTIINESLN FKIRDQLVVG QLIPDCYVEL EKIILSERKN VPIEFPVIDR KRLLQLVREN 1560 QLQLDENELP HAVHFLNESG VLLHFQDPAL QLSDLYFVEP KWLCKIMAQI LTVKVEGCPK 1620 HPKGIISRRD VEKFLSKKRK FPKNYMSQYF KLLEKFQIAL PIGEEYLLVP SSLSDHRPVI 1680 ELPHCENSEI IIRLYEMPYF PMGFWSRLIN RLLEISPYML SGRERALRPN RMYWRQGIYL 1740 NWSPEAYCLV GSEVLDNHPE SFLKITVPSC RKGCILLGQV VDHIDSLMEE WFPGLLEIDI 1800 CGEGETLLKK WALYSFNDGE EHQKILLDDL MKKAEEGDLL VNPDQPRLTI PISQIAPDLI 1860 LADLPRNIML NNDELEFEQA PEFLLGDGSF GSVYRAAYEG EEVAVKIFNK HTSLRLLRQE 1920 LVVLCHLHHP SLISLLAAGI RPRMLVMELA SKGSLDRLLQ QDKASLTRTL QHRIALHVAD 1980 GLRYLHSAMI IYRDLKPHNV LLFTLYPNAA IIAKIADYGI AQYCCRMGIK TSEGTPGFRA 2040 PEVARGNVIY NQQADVYSFG LLLYDILTTG GRIVEGLKFP NEFDELEIQG KLPDPVKEYG 2100 CAPWPMVEKL IKQCLKENPQ ERPTSAQVFD ILNSAELVCL TRRILLPKNV IVECMVATHH 2160 NSRNASIWLG CGHTDRGQLS FLDLNTEGYT SEEVADSRIL CLALVHLPVE KESWIVSGTQ 2220 SGTLLVINTE DGKKRHTLEK MTDSVTCLYC NSFSKQSKQK NFLLVGTADG KLAIFEDKTV 2280 KLKGAAPLKI LNIGNVSTPL MCLSESTNST ERNVMWGGCG TKIFSFSNDF TIQKLIETRT 2340 SQLFSYAAFS DSNIITVVVD TALYIAKQNS PVVEVWDKKT EKLCGLIDCV HFLREVMVKE 2400 NKESKHKMSY SGRVKTLCLQ KNTALWIGTG GGHILLLDLS TRRLIRVIYN FCNSVRVMMT 2460 AQLGSLKNVM LVLGYNRKNT EGTQKQKEIQ SCLTVWDINL PHEVQNLEKH IEVRKELAEK 2520 MRRTSVE 2528 Fasta Sequence >Q5S007\|LRRK2; PARK8\|Homo sapiens (Human) MASGSCQGCEEDEETLKKLIVRLNNVQEGKQIETLVQILEDLLVFTYSERASKLFQGKNIHVPLLIVLDSYMRVASVQQVGWSLLCKLIEVCPGTMQSLMGPQDVGNDWEVLGVHQLILKMLTVHNASVNLSVIGLKTLDLLLTSGKITLLILDEESDIFMLIFDAMHSFPANDEVQKLGCKALHVLFERVSEEQLTEFVENKDYMILLSALTNFKDEEEIVLHVLHCLHSLAIPCNNVEVLMSGNVRCYNIVVEAMKAFPMSERIQEVSCCLLHRLTLGNFFNILVLNEVHEFVVKAVQQYPENAALQISALSCLALLTETIFLNQDLEEKNENQENDDEGEEDKLFWLEACYKALTWHRKNKHVQEAACWALNNLLMYQNSLHEKIGDEDGHFPAHREVMLSMLMHSSSKEVFQASANALSTLLEQNVNFRKILLSKGIHLNVLELMQKHIHSPEVAESGCKMLNHLFEGSNTSLDIMAAVVPKILTVMKRHETSLPVQLEALRAILHFIVPGMPEESREDTEFHHKLNMVKKQCFKNDIHKLVLAALNRFIGNPGIQKCGLKVISSIVHFPDALEMLSLEGAMDSVLHTLQMYPDDQEIQCLGLSLIGYLITKKNVFIGTGHLLAKILVSSLYRFKDVAEIQTKGFQTILAILKLSASFSKLLVHHSFDLVIFHQMSSNIMEQKDQQFLNLCCKCFAKVAMDDYLKNVMLERACDQNNSIMVECLLLLGADANQAKEGSSLICQVCEKESSPKLVELLLNSGSREQDVRKALTISIGKGDSQIISLLLRRLALDVANNSICLGGFCIGKVEPSWLGPLFPDKTSNLRKQTNIASTLARMVIRYQMKSAVEEGTASGSDGNFSEDVLSKFDEWTFIPDSSMDSVFAQSDDLDSEGSEGSFLVKKKSNSISVGEFYRDAVLQRCSPNLQRHSNSLGPIFDHEDLLKRKRKILSSDDSLRSSKLQSHMRHSDSISSLASEREYITSLDLSANELRDIDALSQKCCISVHLEHLEKLELHQNALTSFPQQLCETLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKELKILNLSKNHISSLSENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHIGCKAKDIIRFLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLMKTKKSDLGMQSATVGIDVKDWPIQIRDKRKRDLVLNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKARASSSPVILVGTHLDVSDEKQRKACMSKITKELLNKRGFPAIRDYHFVNATEESDALAKLRKTIINESLNFKIRDQLVVGQLIPDCYVELEKIILSERKNVPIEFPVIDRKRLLQLVRENQLQLDENELPHAVHFLNESGVLLHFQDPALQLSDLYFVEPKWLCKIMAQILTVKVEGCPKHPKGIISRRDVEKFLSKKRKFPKNYMSQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVIELPHCENSEIIIRLYEMPYFPMGFWSRLINRLLEISPYMLSGRERALRPNRMYWRQGIYLNWSPEAYCLVGSEVLDNHPESFLKITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLEIDICGEGETLLKKWALYSFNDGEEHQKILLDDLMKKAEEGDLLVNPDQPRLTIPISQIAPDLILADLPRNIMLNNDELEFEQAPEFLLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQELVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLTRRILLPKNVIVECMVATHHNSRNASIWLGCGHTDRGQLSFLDLNTEGYTSEEVADSRILCLALVHLPVEKESWIVSGTQSGTLLVINTEDGKKRHTLEKMTDSVTCLYCNSFSKQSKQKNFLLVGTADGKLAIFEDKTVKLKGAAPLKILNIGNVSTPLMCLSESTNSTERNVMWGGCGTKIFSFSNDFTIQKLIETRTSQLFSYAAFSDSNIITVVVDTALYIAKQNSPVVEVWDKKTEKLCGLIDCVHFLREVMVKENKESKHKMSYSGRVKTLCLQKNTALWIGTGGGHILLLDLSTRRLIRVIYNFCNSVRVMMTAQLGSLKNVMLVLGYNRKNTEGTQKQKEIQSCLTVWDINLPHEVQNLEKHIEVRKELAEKMRRTSVE

※ PTM-Disease Association

Num	PTM	Disease	Cell Type	Type	PTM Site	PMID
1	Serine Phosphorylation	Parkinson's disease		N	S955	22004453
1	[Reference]: Phosphorylation of LRRK2 serines 955 and 973 is disrupted by Parkinson's disease mutations and LRRK2 pharmacological inhibition
2	Serine Phosphorylation	Parkinson's disease		N	S973	22004453
2	[Reference]: Phosphorylation of LRRK2 serines 955 and 973 is disrupted by Parkinson's disease mutations and LRRK2 pharmacological inhibition
3	Serine Phosphorylation	Parkinson's disease	cell line	P	S1292	23241745
3	[Reference]: Together, these data demonstrate that some LRRK2 PD mutations enhance Ser1292 autophosphorylation in cultured cells and in brain lysates of BAC transgenic mic
4	Serine Phosphorylation	Parkinson's disease		C	S1444	24351927
4	[Reference]: Phosphorylation at S1444 is strikingly reduced in the major PD-related LRRK2 mutations R1441C/G/H

※ Disease Cross-ref Annotation

Database	Annotation
CTD (Curated) (count: 6)	MESH:D002292 ; Carcinoma, Renal Cell MESH:D004715 ; Endometriosis MESH:D009410 ; Nerve Degeneration MESH:D010300 ; Parkinson Disease OMIM:607060 ; PARKINSON DISEASE 8, AUTOSOMAL DOMINANT MESH:D020734 ; Parkinsonian Disorders
DisGeNet (Curated) (count: 11) (view all)	C0007134; Renal Cell Carcinoma C0014175; Endometriosis C0027746; Nerve Degeneration C0030567; Parkinson Disease C0036341; Schizophrenia C0086132; Depressive Symptoms C0242422; Parkinsonian Disorders C1846862; PARKINSON DISEASE 8 (disorder) C3809811; PARKINSON DISEASE 19, JUVENILE-ONSET C4274355; Autosomal dominant late onset Parkinson disease C4275179; Young onset Parkinson disease
HGMD (count: 54) (view all)	CD075458; Parkinson disease; Small deletions CM074927; Parkinson disease; Missense/nonsense CM073188; Parkinson disease; Missense/nonsense CM074929; Parkinson disease; Missense/nonsense CM073187; Parkinson disease; Missense/nonsense CM081692; Parkinson disease; Missense/nonsense CM066915; Parkinson disease, association with; Missense/nonsense CM056640; Parkinson disease; Missense/nonsense CM092473; Parkinson disease ?; Missense/nonsense CM056641; Parkinson disease; Missense/nonsense CM074333; Parkinson disease ?; Missense/nonsense CM053974; Parkinson disease ?; Missense/nonsense CM056642; Parkinson disease; Missense/nonsense CM074926; Parkinson disease; Missense/nonsense CM043517; Parkinson disease; Missense/nonsense CM066120; Parkinson disease ?; Missense/nonsense CM080432; Parkinson disease; Missense/nonsense CM074925; Parkinson disease; Missense/nonsense CM056639; Parkinson disease; Missense/nonsense CM081326; Parkinson disease; Missense/nonsense CM053301; Parkinson disease; Missense/nonsense CM053302; Parkinson disease; Missense/nonsense CM044901; Parkinson disease; Missense/nonsense CM043518; Parkinson disease; Missense/nonsense CM074928; Parkinson disease; Missense/nonsense CM081329; Parkinson disease; Missense/nonsense CM081327; Parkinson disease; Missense/nonsense CM057190; Parkinson disease ?; Missense/nonsense CM082928; Parkinson disease; Missense/nonsense CM084928; Parkinson disease, in Chinese, association with; Missense/nonsense CM043519; Parkinson disease; Missense/nonsense CM081688; Parkinson disease; Missense/nonsense CM081690; Parkinson disease; Missense/nonsense CM074930; Parkinson disease; Missense/nonsense CM053300; Parkinson disease; Missense/nonsense CM067693; Parkinson disease; Missense/nonsense CM067694; Parkinson disease; Missense/nonsense CM054774; Parkinson disease; Missense/nonsense CM070985; Parkinson disease; Missense/nonsense CM061837; Parkinson disease; Missense/nonsense CM050659; Parkinson disease; Missense/nonsense CM043520; Parkinson disease; Missense/nonsense CM070984; Parkinson disease; Missense/nonsense CM081687; Parkinson disease; Missense/nonsense CM081689; Parkinson disease; Missense/nonsense CM081330; Parkinson disease; Missense/nonsense CM054773; Parkinson disease; Missense/nonsense CM057191; Parkinson disease, association with; Missense/nonsense CM081328; Parkinson disease; Missense/nonsense CM081691; Parkinson disease; Missense/nonsense CS055593; Parkinson disease, association with ?; Splicing CS053469; Parkinson disease; Splicing CS053470; Parkinson disease; Splicing CS054202; Parkinson disease ?; Splicing
GWASdb (count: 38) (view all)	rs7294619; Parkinson's disease; Parkinson's disease rs7294619; Taste perception; sensory system disease rs10878226; Taste perception; sensory system disease rs1491942; Parkinson's disease; Parkinson's disease rs1491941; Parkinson's disease; Parkinson's disease rs11175655; Taste perception; sensory system disease rs11175658; Taste perception; sensory system disease rs1352877; Multiple complex diseases; Null rs10878244; Parkinson's disease; Parkinson's disease rs10878245; Coronary Artery Disease; coronary artery disease rs10878245; Taste perception; sensory system disease rs10878246; Parkinson's disease; Parkinson's disease rs954884; Taste perception; sensory system disease rs10878249; Tourette syndrome; Gilles de la Tourette syndrome\|obsessive-compulsive disorder\|attention deficit hyperactivity disorder rs2404580; Taste perception; sensory system disease rs1491938; Taste perception; sensory system disease rs1491938; Tourette syndrome; Gilles de la Tourette syndrome\|obsessive-compulsive disorder\|attention deficit hyperactivity disorder rs1907633; Parkinson's disease; Parkinson's disease rs1907632; Parkinson's disease; Parkinson's disease rs28903073; Parkinson's disease; Parkinson's disease rs11175769; Urinary metabolites; kidney disease rs4293189; Urinary metabolites; kidney disease rs10506151; Volumetric brain MRI; cognitive disorder rs10878307; Lung function (forced vital capacity); lung disease rs10878307; Lung function (forced expiratory volume in 1 second); lung disease rs10784498; Epilepsy; epilepsy syndrome rs7133914; Parkinson's disease; Parkinson's disease rs721709; Progressive supranuclear palsy; progressive supranuclear palsy rs11564148; Parkinson's disease; Parkinson's disease rs11564205; Parkinson's disease; Parkinson's disease rs10878368; Urinary metabolites; kidney disease rs12370996; Body mass index; obesity rs10878386; Parkinson's disease; Parkinson's disease rs1427271; Myasthenia gravis; myasthenia gravis rs1427271; Neutrophil count; hematopoietic system disease\|Human immunodeficiency virus infectious disease rs34637584; Parkinson's disease; Parkinson's disease rs11176195; Aortic root size; cardiovascular system disease rs34778348; Parkinson's disease; Parkinson's disease

※ PTM Sites

PTM	Modification Sites
Phosphorylation (count: 93) (view all)	1007 LSQKCCISVHLEHLE dbPAF 1024 ELHQNALTSFPQQLC dbPAF 1025 LHQNALTSFPQQLCE dbPAF 1058 PSYLLKMSCIANLDV dbPAF 1124 NKISGICSPLRLKEL dbPAF 1157 EACPKVESFSARMNF dbPAF 1159 CPKVESFSARMNFLA dbPAF 1176 PFLPPSMTILKLSQN dbPAF 1219 PGPAHWKSLNLRELL dbPAF 1228 NLRELLFSHNQISIL dbPAF 1253 RVEKLHLSHNKLKEI dbPAF 1283 SYNLELRSFPNEMGK dbPAF 1292 PNEMGKLSKIWDLPL dbPAF 1332 RLKKAVPYNRMKLMI dbPAF 1343 KLMIVGNTGSGKTTL dbPAF 1345 MIVGNTGSGKTTLLQ dbPAF 1348 GNTGSGKTTLLQQLM dbPAF 1349 NTGSGKTTLLQQLMK dbPAF 1357 LLQQLMKTKKSDLGM dbPAF 1368 DLGMQSATVGIDVKD dbPAF 1402 FAGREEFYSTHPHFM dbPAF 1403 AGREEFYSTHPHFMT dbPAF 1404 GREEFYSTHPHFMTQ dbPAF 1410 STHPHFMTQRALYLA dbPAF 1443 FNIKARASSSPVILV dbPAF 1444 NIKARASSSPVILVG dbPAF 1445 IKARASSSPVILVGT dbPAF 1452 SPVILVGTHLDVSDE dbPAF 1457 VGTHLDVSDEKQRKA dbPAF 1467 KQRKACMSKITKELL dbPAF 1470 KACMSKITKELLNKR dbPAF 1485 GFPAIRDYHFVNATE dbPAF 1491 DYHFVNATEESDALA dbPAF 1503 ALAKLRKTIINESLN dbPAF 1508 RKTIINESLNFKIRD dbPAF 1536 ELEKIILSERKNVPI dbPAF 1612 KIMAQILTVKVEGCP dbPAF 1647 KFPKNYMSQYFKLLE dbPAF 1849 NPDQPRLTIPISQIA dbPAF 1853 PRLTIPISQIAPDLI dbPAF 1912 VKIFNKHTSLRLLRQ dbPAF 1913 KIFNKHTSLRLLRQE dbPAF 1967 QQDKASLTRTLQHRI dbPAF 1969 DKASLTRTLQHRIAL dbPAF 2023 ADYGIAQYCCRMGIK dbPAF 2031 CCRMGIKTSEGTPGF dbPAF 2032 CRMGIKTSEGTPGFR dbPAF 2035 GIKTSEGTPGFRAPE dbPAF 2166 HHNSRNASIWLGCGH dbPAF 2237 EDGKKRHTLEKMTDS dbPAF 2257 CNSFSKQSKQKNFLL dbPAF 2449 RRLIRVIYNFCNSVR dbPAF 2460 NSVRVMMTAQLGSLK dbPAF 2483 NRKNTEGTQKQKEIQ dbPAF 2524 LAEKMRRTSVE** dbPAF 3 *MASGSCQGCE dbPAF 424 ASANALSTLLEQNVN dbPAF 489 AVVPKILTVMKRHET dbPAF 496 TVMKRHETSLPVQLE dbPAF 5 *MASGSCQGCEED dbPAF 524 PEESREDTEFHHKLN dbPAF 633 LLAKILVSSLYRFKD dbPAF 634 LAKILVSSLYRFKDV dbPAF 636 KILVSSLYRFKDVAE dbPAF 707 AKVAMDDYLKNVMLE dbPAF 776 QDVRKALTISIGKGD dbPAF 784 ISIGKGDSQIISLLL dbPAF 788 KGDSQIISLLLRRLA dbPAF 826 GPLFPDKTSNLRKQT dbPAF 833 TSNLRKQTNIASTLA dbPAF 837 RKQTNIASTLARMVI dbPAF 838 KQTNIASTLARMVIR dbPAF 850 VIRYQMKSAVEEGTA dbPAF 858 AVEEGTASGSDGNFS dbPAF 860 EEGTASGSDGNFSED dbPAF 865 SGSDGNFSEDVLSKF dbPAF 895 AQSDDLDSEGSEGSF dbPAF 898 DDLDSEGSEGSFLVK dbPAF 908 SFLVKKKSNSISVGE dbPAF 910 LVKKKSNSISVGEFY dbPAF 912 KKKSNSISVGEFYRD dbPAF 926 DAVLQRCSPNLQRHS dbPAF 933 SPNLQRHSNSLGPIF dbPAF 935 NLQRHSNSLGPIFDH dbPAF 954 KRKRKILSSDDSLRS dbPAF 955 RKRKILSSDDSLRSS dbPAF 958 KILSSDDSLRSSKLQ dbPAF 962 SDDSLRSSKLQSHMR dbPAF 971 LQSHMRHSDSISSLA dbPAF 973 SHMRHSDSISSLASE dbPAF 975 MRHSDSISSLASERE dbPAF 976 RHSDSISSLASEREY dbPAF 979 DSISSLASEREYITS dbPAF
Ubiquitination (count: 4)	1132 PLRLKELKILNLSKN PLMD 412 MLMHSSSKEVFQASA PLMD 905 SEGSFLVKKKSNSIS PLMD 906 EGSFLVKKKSNSISV PLMD
Glycation (count: 1)	486 IMAAVVPKILTVMKR PLMD

※ Protein-Protein Interaction

Network

Interaction

A

B

Source

O00231	Q5S007	IntAct
O60260	Q5S007	IntAct
P02686	Q5S007	MINT
P30153	Q5S007	IntAct
P31749	Q5S007	MINT
P46940	Q5S007	IntAct
P55060	Q5S007	IntAct
P62988	Q5S007	DIP
Q13469	Q5S007	IntAct
Q5S007	Q5S007	DIP
Q5S007	Q92973	IntAct
Q5S007	Q9UKV8	DIP
Q5S007	Q9UNE7	DIP