Q5EG47

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession AAPK1_MOUSE; Q5EG47;
Entrez ID 105787
GenBank Protein ID
GenBank Nucleotide ID
Protein Name 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK subunit alpha-1) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (EC 2.7.11.27) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) (Tau-protein kinase PRK
Gene Name Prkaa1
Organism Mus musculus
NCBI Taxa ID 10090
Functional DescriptionCatalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of (view all)
Sequence
(Fasta)
MRRLSSWRKM ATAEKQKHDG RVKIGHYILG DTLGVGTFGK VKVGKHELTG HKVAVKILNR 60
QKIRSLDVVG KIRREIQNLK LFRHPHIIKL YQVISTPSDI FMVMEYVSGG ELFDYICKNG 120
RLDEKESRRL FQQILSGVDY CHRHMVVHRD LKPENVLLDA HMNAKIADFG LSNMMSDGEF 180
LRTSCGSPNY AAPEVISGRL YAGPEVDIWS SGVILYALLC GTLPFDDDHV PTLFKKICDG 240
IFYTPQYLNP SVISLLKHML QVDPMKRAAI KDIREHEWFK QDLPKYLFPE DPSYSSTMID 300
DEALKEVCEK FECSEEEVLS CLYNRNHQDP LAVAYHLIID NRRIMNEAKD FYLATSPPDS 360
FLDDHHLTRP HPERVPFLVA ETPRARHTLD ELNPQKSKHQ GVRKAKWHLG IRSQSRPNDI 420
MAEVCRAIKQ LDYEWKVVNP YYLRVRRKNP VTSTFSKMSL QLYQVDSRTY LLDFRSIDDE 480
ITEAKSGTAT PQRSGSISNY RSCQRSDSDA EAQGKPSDVS LTSSVTSLDS SPVDVAPRPG 540
SHTIEFFEMC ANLIKILAQ

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Threonine PhosphorylationHeart failureUT18320497424
[Reference]: A distinct AMP-activated protein kinase phosphorylation site characterizes cardiac hypertrophy induced by L-thyroxine and angiotensin II.

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 3)
MESH:D018149 ; Glucose Intolerance
MESH:D007333 ; Insulin Resistance
MESH:D013274 ; Stomach Neoplasms

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 26)
(view all)
172       KIADFGLSNMMSDGE     dbPAF
176       FGLSNMMSDGEFLRT     dbPAF
183       SDGEFLRTSCGSPNY     dbPAF
184       DGEFLRTSCGSPNYA     dbPAF
187       FLRTSCGSPNYAAPE     dbPAF
32        GHYILGDTLGVGTFG     dbPAF
Acetylation
(count: 1)
80        RREIQNLKLFRHPHI     PLMD
Ubiquitination
(count: 1)
396       LDELNPQKSKHQGVR     PLMD
Malonylation
(count: 1)
80        RREIQNLKLFRHPHI     PLMD
Succinylation
(count: 1)
80        RREIQNLKLFRHPHI     PLMD