Tag | Content |
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UniProt Accession | AAPK1_MOUSE; Q5EG47; |
Entrez ID | 105787 |
GenBank Protein ID | |
GenBank Nucleotide ID | |
Protein Name | 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK subunit alpha-1) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (EC 2.7.11.27) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) (Tau-protein kinase PRK |
Gene Name | Prkaa1 |
Organism | Mus musculus |
NCBI Taxa ID | 10090 |
Functional Description | Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of (view all) |
Sequence (Fasta) | MRRLSSWRKM ATAEKQKHDG RVKIGHYILG DTLGVGTFGK VKVGKHELTG HKVAVKILNR 60 QKIRSLDVVG KIRREIQNLK LFRHPHIIKL YQVISTPSDI FMVMEYVSGG ELFDYICKNG 120 RLDEKESRRL FQQILSGVDY CHRHMVVHRD LKPENVLLDA HMNAKIADFG LSNMMSDGEF 180 LRTSCGSPNY AAPEVISGRL YAGPEVDIWS SGVILYALLC GTLPFDDDHV PTLFKKICDG 240 IFYTPQYLNP SVISLLKHML QVDPMKRAAI KDIREHEWFK QDLPKYLFPE DPSYSSTMID 300 DEALKEVCEK FECSEEEVLS CLYNRNHQDP LAVAYHLIID NRRIMNEAKD FYLATSPPDS 360 FLDDHHLTRP HPERVPFLVA ETPRARHTLD ELNPQKSKHQ GVRKAKWHLG IRSQSRPNDI 420 MAEVCRAIKQ LDYEWKVVNP YYLRVRRKNP VTSTFSKMSL QLYQVDSRTY LLDFRSIDDE 480 ITEAKSGTAT PQRSGSISNY RSCQRSDSDA EAQGKPSDVS LTSSVTSLDS SPVDVAPRPG 540 SHTIEFFEMC ANLIKILAQ |
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Database | Annotation |
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CTD (Curated) (count: 3) | MESH:D018149
; Glucose Intolerance MESH:D007333 ; Insulin Resistance MESH:D013274 ; Stomach Neoplasms |
PTM | Modification Sites |
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Phosphorylation (count: 26) (view all) | 172 KIADFGLSNMMSDGE dbPAF
176 FGLSNMMSDGEFLRT dbPAF 183 SDGEFLRTSCGSPNY dbPAF 184 DGEFLRTSCGSPNYA dbPAF 187 FLRTSCGSPNYAAPE dbPAF 32 GHYILGDTLGVGTFG dbPAF |
Acetylation (count: 1) | 80 RREIQNLKLFRHPHI PLMD |
Ubiquitination (count: 1) | 396 LDELNPQKSKHQGVR PLMD |
Malonylation (count: 1) | 80 RREIQNLKLFRHPHI PLMD |
Succinylation (count: 1) | 80 RREIQNLKLFRHPHI PLMD |