Q53HL2

PTMD Annotation Information

※ Protein Information

Tag	Content
UniProt Accession	BOREA_HUMAN; Q53HL2;
Entrez ID	55143
GenBank Protein ID	NM_001256875.1; NM_018101.3;
GenBank Nucleotide ID	NP_001243804.1; NP_060571.1;
Protein Name	Borealin (Cell division cycle-associated protein 8) (Dasra-B) (hDasra-B) (Pluripotent embryonic stem cell-related gene 3 protein)
Gene Name	CDCA8; PESCRG3
Organism	Homo sapiens
NCBI Taxa ID	9606
Functional Description	Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment. Functional Description Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment.
Sequence (Fasta)	MAPRKGSSRV AKTNSLRRRK LASFLKDFDR EVEIRIKQIE SDRQNLLKEV DNLYNIEILR 60 LPKALREMNW LDYFALGGNK QALEEAATAD LDITEINKLT AEAIQTPLKS AKTRKVIQVD 120 EMIVEEEEEE ENERKNLQTA RVKRCPPSKK RTQSIQGKGK GKRSSRANTV TPAVGRLEVS 180 MVKPTPGLTP RFDSRVFKTP GLRTPAAGER IYNISGNGSP LADSKEIFLT VPVGGGESLR 240 LLASDLQRHS IAQLDPEALG NIKKLSNRLA QICSSIRTHK 281 Fasta Sequence >Q53HL2\|CDCA8; PESCRG3\|Homo sapiens (Human) MAPRKGSSRVAKTNSLRRRKLASFLKDFDREVEIRIKQIESDRQNLLKEVDNLYNIEILRLPKALREMNWLDYFALGGNKQALEEAATADLDITEINKLTAEAIQTPLKSAKTRKVIQVDEMIVEEEEEEENERKNLQTARVKRCPPSKKRTQSIQGKGKGKRSSRANTVTPAVGRLEVSMVKPTPGLTPRFDSRVFKTPGLRTPAAGERIYNISGNGSPLADSKEIFLTVPVGGGESLRLLASDLQRHSIAQLDPEALGNIKKLSNRLAQICSSIRTHK

※ PTM-Disease Association

Num	PTM	Disease	Cell Type	Type	PTM Site	PMID
1	Serine Phosphorylation	Lung cancer/carcinoma		U	S275	17483322
1	[Reference]: AURKB directly phosphorylated CDCA8 at Ser(154), Ser(219), Ser(275), and Thr(278) and seemed to stabilize CDCA8 protein in cancer cells.
2	Threonine Phosphorylation	Lung cancer/carcinoma		U	T278	17483322
2	[Reference]: AURKB directly phosphorylated CDCA8 at Ser(154), Ser(219), Ser(275), and Thr(278) and seemed to stabilize CDCA8 protein in cancer cells.

※ Disease Cross-ref Annotation

Database	Annotation
GWASdb (count: 4)	rs615530; Alcohol dependence; alcohol dependence rs3790623; HIV-1 progression to AIDS and death; Human immunodeficiency virus infectious disease rs531454; Alcohol dependence; alcohol dependence rs7822; Suicide attempts in bipolar disorder; bipolar disorder

※ PTM Sites

PTM	Modification Sites
Phosphorylation (count: 31) (view all)	100 ITEINKLTAEAIQTP dbPAF 106 LTAEAIQTPLKSAKT dbPAF 110 AIQTPLKSAKTRKVI dbPAF 13 GSSRVAKTNSLRRRK dbPAF 15 SRVAKTNSLRRRKLA dbPAF 152 CPPSKKRTQSIQGKG dbPAF 154 PSKKRTQSIQGKGKG dbPAF 164 GKGKGKRSSRANTVT dbPAF 165 KGKGKRSSRANTVTP dbPAF 169 KRSSRANTVTPAVGR dbPAF 171 SSRANTVTPAVGRLE dbPAF 180 AVGRLEVSMVKPTPG dbPAF 185 EVSMVKPTPGLTPRF dbPAF 189 VKPTPGLTPRFDSRV dbPAF 194 GLTPRFDSRVFKTPG dbPAF 199 FDSRVFKTPGLRTPA dbPAF 204 FKTPGLRTPAAGERI dbPAF 212 PAAGERIYNISGNGS dbPAF 215 GERIYNISGNGSPLA dbPAF 219 YNISGNGSPLADSKE dbPAF 224 NGSPLADSKEIFLTV dbPAF 23 LRRRKLASFLKDFDR dbPAF 230 DSKEIFLTVPVGGGE dbPAF 238 VPVGGGESLRLLASD dbPAF 244 ESLRLLASDLQRHSI dbPAF 250 ASDLQRHSIAQLDPE dbPAF 274 NRLAQICSSIRTHK* dbPAF 275 RLAQICSSIRTHK dbPAF 278 QICSSIRTHK*** dbPAF 88 QALEEAATADLDITE dbPAF 94 ATADLDITEINKLTA dbPAF
Acetylation (count: 1)	183 RLEVSMVKPTPGLTP PLMD
Ubiquitination (count: 7) (view all)	109 EAIQTPLKSAKTRKV PLMD 183 RLEVSMVKPTPGLTP PLMD 198 RFDSRVFKTPGLRTP PLMD 225 GSPLADSKEIFLTVP PLMD 263 PEALGNIKKLSNRLA PLMD 264 EALGNIKKLSNRLAQ PLMD 37 REVEIRIKQIESDRQ PLMD

※ Protein-Protein Interaction

Network

Interaction

A

B

Source

O15392	Q53HL2	DIP; IntAct; MINT
Q53HL2	Q96GD4	HPRD; DIP; IntAct