| Tag | Content |
|---|---|
| UniProt Accession | PDCD4_HUMAN; Q53EL6; |
| Entrez ID | 27250 |
| GenBank Protein ID | NM_014456.4; NM_145341.3; |
| GenBank Nucleotide ID | NP_055271.2; NP_663314.1; |
| Protein Name | Programmed cell death protein 4 (Neoplastic transformation inhibitor protein) (Nuclear antigen H731-like) (Protein 197/15a) |
| Gene Name | PDCD4; H731 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity). |
| Sequence (Fasta) | MDVENEQILN VNPADPDNLS DSLFSGDEEN AGTEEIKNEI NGNWISASSI NEARINAKAK 60 RRLRKNSSRD SGRGDSVSDS GSDALRSGLT VPTSPKGRLL DRRSRSGKGR GLPKKGGAGG 120 KGVWGTPGQV YDVEEVDVKD PNYDDDQENC VYETVVLPLD ERAFEKTLTP IIQEYFEHGD 180 TNEVAEMLRD LNLGEMKSGV PVLAVSLALE GKASHREMTS KLLSDLCGTV MSTTDVEKSF 240 DKLLKDLPEL ALDTPRAPQL VGQFIARAVG DGILCNTYID SYKGTVDCVQ ARAALDKATV 300 LLSMSKGGKR KDSVWGSGGG QQSVNHLVKE IDMLLKEYLL SGDISEAEHC LKELEVPHFH 360 HELVYEAIIM VLESTGESTF KMILDLLKSL WKSSTITVDQ MKRGYERIYN EIPDINLDVP 420 HSYSVLERFV EECFQAGIIS KQLRDLCPSR GRKRFVSEGD GGRLKPESY |
|
||||||||||||||||||||
| Database | Annotation |
|---|---|
| CTD (Curated) (count: 2) | MESH:D002471
; Cell Transformation, Neoplastic MESH:D009361 ; Neoplasm Invasiveness |
| DisGeNet (Curated) (count: 1) | C0027626; Neoplasm Invasiveness |
| GWASdb (count: 1) | rs10787287; Body mass index (education interaction); obesity |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 33) (view all) | 126 GGKGVWGTPGQVYDV dbPAF
131 WGTPGQVYDVEEVDV dbPAF 143 VDVKDPNYDDDQENC dbPAF 152 DDQENCVYETVVLPL dbPAF 20 PADPDNLSDSLFSGD dbPAF 22 DPDNLSDSLFSGDEE dbPAF |
| Acetylation (count: 2) | 297 QARAALDKATVLLSM PLMD
306 TVLLSMSKGGKRKDS PLMD |
| Ubiquitination (count: 15) (view all) | 139 DVEEVDVKDPNYDDD PLMD
166 LDERAFEKTLTPIIQ PLMD 197 DLNLGEMKSGVPVLA PLMD 212 VSLALEGKASHREMT PLMD 238 MSTTDVEKSFDKLLK PLMD 242 DVEKSFDKLLKDLPE PLMD |
| Sumoylation (count: 1) | 465 EGDGGRLKPESY*** PLMD |
| Network | Interaction | ||
|---|---|---|---|
| A | B | Source | |